PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30679569-0	2019	5-Fluorouracil Induces Enteric Neuron Death and Glial Activation During Intestinal Mucositis via a S100B-RAGE-NFkappaB-Dependent Pathway.	Fluorouracil	0-14	S100 calcium binding protein B	Homo sapiens	99-104	
30679569-2	2019	In this report, we used an animal model to investigate the participation of the S100B/RAGE/NFkappaB pathway in intestinal mucositis and enteric neurotoxicity caused by 5-FU (450 mg/kg, IP, single dose).	Fluorouracil	168-172	S100 calcium binding protein B	Homo sapiens	80-85	
30679569-3	2019	5-FU induced intestinal damage observed by shortened villi, loss of crypt architecture and intense inflammatory cell infiltrate as well as increased GFAP and S100B co-expression and decreased HuC/D protein expression in the small intestine.	Fluorouracil	0-4	S100 calcium binding protein B	Homo sapiens	158-163	
30679569-5	2019	We provide evidence that 5-FU induces reactive gliosis and reduction of enteric neurons in a S100B/RAGE/NFkappaB-dependent manner, since pentamidine, a S100B inhibitor, prevented 5-FU-induced neuronal loss, enteric glia activation, intestinal inflammation, oxidative stress and histological injury.	Fluorouracil	25-29	S100 calcium binding protein B	Homo sapiens	93-98	
30679569-5	2019	We provide evidence that 5-FU induces reactive gliosis and reduction of enteric neurons in a S100B/RAGE/NFkappaB-dependent manner, since pentamidine, a S100B inhibitor, prevented 5-FU-induced neuronal loss, enteric glia activation, intestinal inflammation, oxidative stress and histological injury.	Fluorouracil	25-29	S100 calcium binding protein B	Homo sapiens	152-157	
30679569-5	2019	We provide evidence that 5-FU induces reactive gliosis and reduction of enteric neurons in a S100B/RAGE/NFkappaB-dependent manner, since pentamidine, a S100B inhibitor, prevented 5-FU-induced neuronal loss, enteric glia activation, intestinal inflammation, oxidative stress and histological injury.	Fluorouracil	179-183	S100 calcium binding protein B	Homo sapiens	93-98	
30679569-5	2019	We provide evidence that 5-FU induces reactive gliosis and reduction of enteric neurons in a S100B/RAGE/NFkappaB-dependent manner, since pentamidine, a S100B inhibitor, prevented 5-FU-induced neuronal loss, enteric glia activation, intestinal inflammation, oxidative stress and histological injury.	Fluorouracil	179-183	S100 calcium binding protein B	Homo sapiens	152-157