PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1327592-6	1992	Complement degradation products C3a and C5a were produced in normal serum treated with hydrogen peroxide, and 20 mM EDTA abolished C3a and C5a production in hydrogen peroxide-treated serum but 20 mM Mg-EGTA did not.	Edetic Acid	116-120	complement C3	Homo sapiens	32-35	
10535262-6	1999	Western blotting assay of these plasma samples without EDTA-added blood found the presence of both C5a and C3a.	Edetic Acid	55-59	complement C3	Homo sapiens	107-110	
10430784-5	1999	Futhan/EDTA prevented C3a and C4a generation in blood and plasma samples held at room temperature (22-23 degrees C) for 1 h and in plasma held for 24 h at 4 degrees C or -70 degrees C. The mean C3a concentration (1.76 mg/L; n = 19) at time 0 in EDTA plasma samples from liver transplant patients was significantly higher than for controls (0.34 mg/L; n = 11).	Edetic Acid	7-11	complement C3	Homo sapiens	22-25	
10430784-5	1999	Futhan/EDTA prevented C3a and C4a generation in blood and plasma samples held at room temperature (22-23 degrees C) for 1 h and in plasma held for 24 h at 4 degrees C or -70 degrees C. The mean C3a concentration (1.76 mg/L; n = 19) at time 0 in EDTA plasma samples from liver transplant patients was significantly higher than for controls (0.34 mg/L; n = 11).	Edetic Acid	7-11	complement C3	Homo sapiens	194-197	
10430784-6	1999	In these patients, the mean C3a in EDTA samples increased to 13.8 mg/L after 60 min at room temperature, but there was no change in the C3a concentration of an EDTA plasma from a control.	Edetic Acid	35-39	complement C3	Homo sapiens	28-31	
10430784-7	1999	In the patients, C3a concentrations were lower in Futhan/EDTA plasma than in EDTA at time 0 and after 60 min at room temperature (1.40 and 2.02 mg/L, respectively).	Edetic Acid	57-61	complement C3	Homo sapiens	17-20	
10430784-7	1999	In the patients, C3a concentrations were lower in Futhan/EDTA plasma than in EDTA at time 0 and after 60 min at room temperature (1.40 and 2.02 mg/L, respectively).	Edetic Acid	77-81	complement C3	Homo sapiens	17-20	
10647874-2	2000	Longitudinal EDTA-plasma levels of C3a and C4a were measured by quantitative radioimmunoassay.	Edetic Acid	13-17	complement C3	Homo sapiens	35-38	
9301541-8	1997	In addition, the in vivo-bound C3b fragments were degraded to C3d,g when the patients" PBL were incubated in homologous serum containing EDTA.	Edetic Acid	137-141	complement C3	Homo sapiens	31-34	
1327592-6	1992	Complement degradation products C3a and C5a were produced in normal serum treated with hydrogen peroxide, and 20 mM EDTA abolished C3a and C5a production in hydrogen peroxide-treated serum but 20 mM Mg-EGTA did not.	Edetic Acid	116-120	complement C3	Homo sapiens	131-134	
1937941-3	1991	Venous line plasma C3a concentrations before EDTA infusion were significantly higher than after EDTA.	Edetic Acid	45-49	complement C3	Homo sapiens	19-22	
1937941-4	1991	Also, venous line plasma C3a concentrations before and after EDTA infusion were significantly higher than in the arterial line.	Edetic Acid	61-65	complement C3	Homo sapiens	25-28	
3707864-7	1986	Prevention of C3b generation (with 10 mM EDTA) during opsonization abrogated both immune adherence and PMN-mediated GSH decline in oxidant-sensitive cells.	Edetic Acid	41-45	complement C3	Homo sapiens	14-17	
2532618-3	1989	It bound to cell-bound C3b and stabilized C3bBb at 30 degrees in the presence of EDTA-GVB.	Edetic Acid	81-85	complement C3	Homo sapiens	23-26	
1838328-5	1991	Further incubation of BAC1,4b,2a,3b with EDTA-GVB at 37 degrees C gave particles carrying IgG and C4b,C3b (BAC4b,3b).	Edetic Acid	41-45	complement C3	Homo sapiens	102-105	
3257998-3	1988	These findings indicated that the antibody could be used in an assay to detect C3a in human EDTA-plasma without prior separation of C3a from native C3.	Edetic Acid	92-96	complement C3	Homo sapiens	79-82	
2958692-7	1987	The C1q-mediated agglutination of EC3b was inhibited by EDTA, MgEGTA, C3b and Factor B but not by native C3 or collagen.	Edetic Acid	56-60	complement C3	Homo sapiens	35-38	
3634188-7	1986	Using a sensitive hemolytic assay, however, we estimated that the functional activity of B with surface-bound C3b is 80-fold greater in the presence of physiological Mg2+ (0.5 mM) than in 2 mM EDTA.	Edetic Acid	193-197	complement C3	Homo sapiens	110-113	
606442-4	1977	This enzyme was shown further to activate the C3b feedback cycle as shown by its ability to consume factor B in serum and the reduction in the extent of complement consumption in the presence of EDTA.	Edetic Acid	195-199	complement C3	Homo sapiens	46-49	
6236231-6	1984	Normal erythrocytes could be induced to manifest the appearance of the 126,000 D band, and the increased efficiency of binding of nascent C3b by incubation with CCAD serum or with the purified cold agglutinin antibody plus autologous serum, but not with the purified antibody alone or the purified antibody plus EDTA-chelated autologous serum.	Edetic Acid	312-316	complement C3	Homo sapiens	138-141	
6251127-4	1980	Metrizamide caused enhanced conversion of C3 and factor B that was only partially inhibited by ethylene glycol tetracetic acid (EGTA) but completely inhibited by ethylenediaminetetraacetic acid (EDTA).	Edetic Acid	162-193	complement C3	Homo sapiens	42-57	
6251127-4	1980	Metrizamide caused enhanced conversion of C3 and factor B that was only partially inhibited by ethylene glycol tetracetic acid (EGTA) but completely inhibited by ethylenediaminetetraacetic acid (EDTA).	Edetic Acid	195-199	complement C3	Homo sapiens	42-57	
6928644-2	1980	This C3b uptake was blocked by EDTA and was not shown by uninfected cells.	Edetic Acid	31-35	complement C3	Homo sapiens	5-8	
20513355-4	2010	Both heparin and a homologue of C3b, substrates binding to the C-terminus of Factor H, were inhibitory of the interaction, as was EDTA.	Edetic Acid	130-134	complement C3	Homo sapiens	32-35	
25079699-8	2015	Patients with acute aHUS showed elevated levels of C3b/c (P < 0 01), C3bBbP (P < 0 0001) and TCC (P < 0 0001) in EDTA plasma, while values of patients in remission were normal, compared to those of healthy controls.	Edetic Acid	122-126	complement C3	Homo sapiens	51-54	
17411080-7	2007	Protease inhibitors within an EDTA-plasma-collection device inhibit both intrinsic plasma peptidases and proteases and moderate the time-dependent changes of the plasma peptides, including bradykinin, and complement C4- and C3- derived peptides.	Edetic Acid	30-34	complement C3	Homo sapiens	205-226	
19309011-6	2009	The distribution of several spots around pI 5.0-5.6 and apparent molecular mass 1.2-1.5x10(2) kDa was also found to be different; the fragments of complement C3 and C4 were detected in heparin-plasma but not in EDTA-plasma.	Edetic Acid	211-215	complement C3	Homo sapiens	147-160	
12218150-3	2002	The enhancing effect of semen was complement dependent, as evidenced by blockage of generation of C3a/C3a(desArg) in semen by heat or EDTA treatment of semen and suppression of semen-dependent enhancement with mAbs directed to complement receptor type 3 (CD11b/CD18) and soluble CD16.	Edetic Acid	134-138	complement C3	Homo sapiens	98-101	
12218150-3	2002	The enhancing effect of semen was complement dependent, as evidenced by blockage of generation of C3a/C3a(desArg) in semen by heat or EDTA treatment of semen and suppression of semen-dependent enhancement with mAbs directed to complement receptor type 3 (CD11b/CD18) and soluble CD16.	Edetic Acid	134-138	complement C3	Homo sapiens	102-105