PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7482417-6 1995 Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained sensitive to dissociation by EDTA over a 3 h time course, retained its ability to support aggregation, even when aggregation was induced 60 min after the initial platelet exposure to fibrinogen, and remained accessible to polyclonal antibodies and plasmin. Edetic Acid 133-137 fibrinogen beta chain Homo sapiens 53-63 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Edetic Acid 235-239 fibrinogen beta chain Homo sapiens 26-36 10484747-2 1999 They can cleave the human fibrinogen to release the fibrinopeptide A and fibrinopeptide B with specific activity of 120 and 370 NIH units/mg, respectively; the fibrinogen-clotting activity can be inhibited distinctly by PMSF or DFP or EDTA, but not by heparin. Edetic Acid 235-239 fibrinogen beta chain Homo sapiens 160-170 16793707-5 1998 Platelets in the aggregates that formed, underwent rapid disaggregation on addition of EDTA or a GpIIb-IIIa antagonist such as MK-852 and GR144053F, all of which are agents that interfere with the ability of fibrinogen to interact with GpIIb-IIIa. Edetic Acid 87-91 fibrinogen beta chain Homo sapiens 208-218 10064005-4 1999 Polymerization of fibrin monomers derived from purified fibrinogen was delayed in the presence of either calcium or EDTA. Edetic Acid 116-120 fibrinogen beta chain Homo sapiens 56-66 10064005-8 1999 In the presence of 10 mM EDTA, the conversion of variant fragment D1 to D2 was accelerated whereas the degradation of fragment D2 to D3 was delayed in comparison to degradation of fragments D1 and D2 of normal fibrinogen. Edetic Acid 25-29 fibrinogen beta chain Homo sapiens 210-220 7482417-6 1995 Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained sensitive to dissociation by EDTA over a 3 h time course, retained its ability to support aggregation, even when aggregation was induced 60 min after the initial platelet exposure to fibrinogen, and remained accessible to polyclonal antibodies and plasmin. Edetic Acid 133-137 fibrinogen beta chain Homo sapiens 53-63 7526817-7 1994 The correlation of citrate and EDTA fibrinogen values (fibrometer) was r = .9718; for citrate and special anticoagulant plasma, r = .9717. Edetic Acid 31-35 fibrinogen beta chain Homo sapiens 36-46 7740524-3 1995 Therefore, fibrinogen was intentionally exposed to various denaturating conditions (freeze-drying, heating, EDTA, alkali), and the clottability, the thrombin clotting time and the t-PA-stimulating effect were recorded. Edetic Acid 108-112 fibrinogen beta chain Homo sapiens 11-21 7875035-3 1994 In addition, EDTA and barbourin, a KGD-containing peptide, were found to inhibit the binding of fluorescein-fibrinogen. Edetic Acid 13-17 fibrinogen beta chain Homo sapiens 108-118 7526817-9 1994 We conclude that (1) fibrinogen may be measured by clot-rate assay in EDTA-containing samples and that values may be compared with values obtained from citrate plasma with a correction; (2) samples containing PPACK may be used with only slight modification of the method; and (3) values obtained on the analyzer are directly comparable with those obtained on the fibrometer, facilitating large studies. Edetic Acid 70-74 fibrinogen beta chain Homo sapiens 21-31 7841314-0 1994 Freeze-dried fibrinogen or fibrinogen in EDTA stimulate the tissue-type plasminogen activator-catalysed conversion of plasminogen to plasmin. Edetic Acid 41-45 fibrinogen beta chain Homo sapiens 13-23 7865683-0 1994 Fibrinogen present in EDTA--anticoagulated plasma stimulates the tissue-type plasminogen activator-catalysed conversion of plasminogen to plasmin. Edetic Acid 22-26 fibrinogen beta chain Homo sapiens 0-10 7865683-3 1994 It was previously shown that treatment of purified fibrinogen by EDTA, which removes the three tightly bound Ca2+ ions, results in exposure of tissue-type plasminogen activator-catalytic sites similar to those unveiled by thrombin. Edetic Acid 65-69 fibrinogen beta chain Homo sapiens 51-61 7865683-7 1994 The most probable explanation is that tissue-type plasminogen activator-stimulating sites are exposed in fibrinogen by EDTA. Edetic Acid 119-123 fibrinogen beta chain Homo sapiens 105-115 7523416-7 1994 Pretreatment of normal platelets with 5 mM EDTA (37 degrees C for 90 min) or RGDS (2 mM), which disrupts the binding of various adhesive proteins to platelet integrins and inhibits fibrinogen-mediated platelet aggregation, did not alter the vWF-stimulated activation and cytoskeletal association of PtdIns 3-kinase and pp60c-src. Edetic Acid 43-47 fibrinogen beta chain Homo sapiens 181-191 8083588-1 1994 Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 190-221 fibrinogen beta chain Homo sapiens 0-10 8083588-1 1994 Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 190-221 fibrinogen beta chain Homo sapiens 95-105 8083588-1 1994 Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 223-227 fibrinogen beta chain Homo sapiens 0-10 8083588-1 1994 Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 223-227 fibrinogen beta chain Homo sapiens 95-105 7841314-0 1994 Freeze-dried fibrinogen or fibrinogen in EDTA stimulate the tissue-type plasminogen activator-catalysed conversion of plasminogen to plasmin. Edetic Acid 41-45 fibrinogen beta chain Homo sapiens 27-37 8241506-8 1993 This correlated with the EDTA-reversible nature of Zn+2-activated platelet adhesion to fibrinogen-coated surfaces. Edetic Acid 25-29 fibrinogen beta chain Homo sapiens 87-97 8241506-9 1993 The data (1) show that platelet adhesion to fibrinogen is accompanied by the induction of high-affinity interactions between GPIIb-IIIa and immobilized fibrinogen that are EDTA-resistant and enhanced by platelet activation with some but not all agonists, and (2) implicate these interactions in stabilizing platelet contacts with fibrinogen-coated surfaces. Edetic Acid 172-176 fibrinogen beta chain Homo sapiens 44-54 8241506-9 1993 The data (1) show that platelet adhesion to fibrinogen is accompanied by the induction of high-affinity interactions between GPIIb-IIIa and immobilized fibrinogen that are EDTA-resistant and enhanced by platelet activation with some but not all agonists, and (2) implicate these interactions in stabilizing platelet contacts with fibrinogen-coated surfaces. Edetic Acid 172-176 fibrinogen beta chain Homo sapiens 152-162 8241506-9 1993 The data (1) show that platelet adhesion to fibrinogen is accompanied by the induction of high-affinity interactions between GPIIb-IIIa and immobilized fibrinogen that are EDTA-resistant and enhanced by platelet activation with some but not all agonists, and (2) implicate these interactions in stabilizing platelet contacts with fibrinogen-coated surfaces. Edetic Acid 172-176 fibrinogen beta chain Homo sapiens 152-162 1333636-1 1992 In plasma from healthy subjects a coupling was identified between von Willebrand factor (vWf), fibrinogen (fg), and fibronectin (fn) that was dependent of anticoagulants heparin, EDTA, and citrate. Edetic Acid 179-183 fibrinogen beta chain Homo sapiens 95-105 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Edetic Acid 0-31 fibrinogen beta chain Homo sapiens 58-68 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Edetic Acid 0-31 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Edetic Acid 0-31 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Edetic Acid 0-31 fibrinogen beta chain Homo sapiens 149-159 1431204-4 1992 EDTA is known to induce an irreversible dissociation of the platelet membrane glycoprotein(GP)IIb-IIIa, the alpha IIb beta 3 platelet-specific intergrin, a calcium-dependent heterodimer that serves as an inducible receptor for fibrinogen and is essential for platelet aggregation. Edetic Acid 0-4 fibrinogen beta chain Homo sapiens 227-237 1597001-0 1992 Effect of processing time and storage on fibrinogen content of EDTA plasma assayed by radial immunodiffusion. Edetic Acid 63-67 fibrinogen beta chain Homo sapiens 41-51 1440503-6 1992 Over the same time course, fibrinogen binding to control platelets, stimulated with thrombin or ADP, was not only accompanied by a 70% decrease in antifibrinogen antibody binding, but also an inability of EDTA or excess exogenous fibrinogen to dissociate more than half of platelet-associated fibrinogen, as well as the progressive association of bound fibrinogen with the platelet cytoskeleton. Edetic Acid 205-209 fibrinogen beta chain Homo sapiens 27-37 3005363-4 1986 EDTA completely blocked the initiation of aggregation and reversed the fibrinogen-induced aggregation of elastase-treated platelets. Edetic Acid 0-4 fibrinogen beta chain Homo sapiens 71-81 1899346-7 1991 Both development of EDTA-resistant fibrinogen binding and fibrinogen association with the cytoskeleton were time dependent and reached maxima 45 to 60 minutes after fibrinogen binding to stimulated platelets. Edetic Acid 20-24 fibrinogen beta chain Homo sapiens 35-45 2922698-4 1989 Whole blood anticoagulated by heparin, EDTA or sodium citrate, contained dephosphorylating activity against 32P-labeled fibrinogen, although there were significant differences in activity among the three anticoagulants. Edetic Acid 39-43 fibrinogen beta chain Homo sapiens 120-130 2455569-4 1988 The binding of 125I-fibrinogen to platelets occurred in a PMA2 concentration-dependent manner and was blocked by EDTA or an anti-glycoprotein (GP)IIb-IIIa monoclonal antibody. Edetic Acid 113-117 fibrinogen beta chain Homo sapiens 20-30 1899346-1 1991 Previous studies indicated a correlation between the formation of EDTA-resistant (irreversible) platelet-fibrinogen interactions and platelet cytoskeleton formation. Edetic Acid 66-70 fibrinogen beta chain Homo sapiens 105-115 1899346-2 1991 The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated with 20 mumol/L adenosine diphosphate (ADP) or 150 mU/mL human thrombin (THR) when bound fibrinogen had become resistant to dissociation by EDTA. Edetic Acid 371-375 fibrinogen beta chain Homo sapiens 68-78 1827546-1 1991 The alpha-chain of human fibrinogen was found to be phosphorylated in EDTA-anticoagulated whole blood when trace amounts of (gamma-32P)ATP and 7.5 mM Mg2+ ions were added. Edetic Acid 70-74 fibrinogen beta chain Homo sapiens 25-35 2914364-1 1989 In this assay we measure the turbidity produced by precipitation of plasma fibrinogen with a reagent composed of ammonium sulfate, EDTA, and guanidine hydrochloride. Edetic Acid 131-135 fibrinogen beta chain Homo sapiens 75-85 2826623-3 1988 Fibrinogen binding to human, gel-filtered platelets was assessed by using intact fibrinogen and a plasmic fibrinogen degradation product (8D-50) lacking intact alpha chains and resembling an intermediate fragment X. Irreversibly bound fibrinogen was defined as fibrinogen that remained associated with thrombin-stimulated platelets in the presence of 10 mmol/L ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 361-392 fibrinogen beta chain Homo sapiens 0-10 2826623-3 1988 Fibrinogen binding to human, gel-filtered platelets was assessed by using intact fibrinogen and a plasmic fibrinogen degradation product (8D-50) lacking intact alpha chains and resembling an intermediate fragment X. Irreversibly bound fibrinogen was defined as fibrinogen that remained associated with thrombin-stimulated platelets in the presence of 10 mmol/L ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Edetic Acid 394-398 fibrinogen beta chain Homo sapiens 0-10 2861869-2 1985 Fibrin polymers derived from des A fibrinogen and des A,B fibrinogen increased sixfold the rate of thrombin-catalyzed factor XIIIa formation in the presence of EDTA. Edetic Acid 160-164 fibrinogen beta chain Homo sapiens 35-45 2861869-2 1985 Fibrin polymers derived from des A fibrinogen and des A,B fibrinogen increased sixfold the rate of thrombin-catalyzed factor XIIIa formation in the presence of EDTA. Edetic Acid 160-164 fibrinogen beta chain Homo sapiens 58-68 3158213-2 1985 In the present study, irreversibly bound fibrinogen was defined as that fraction of bound iodinated fibrinogen that failed to dissociate from stimulated human gel-filtered platelets within 10 min of adding 10 mM ethylenediaminetetraacetic acid. Edetic Acid 212-243 fibrinogen beta chain Homo sapiens 41-51 6712666-3 1984 When such digests are subjected to affinity chromatography on immobilized fibrinogen, only the fragments with Mr of 120,000 and 140,000 are specifically bound and subsequently eluted by the addition of EDTA to the column buffer. Edetic Acid 202-206 fibrinogen beta chain Homo sapiens 74-84 6410532-4 1983 Although EDTA deaggregated chymotrypsin-treated platelets aggregated by fibrinogen in a medium containing a physiological concentration of Ca2+, EDTA did not deaggregate these platelets if they were in a medium without calcium in which the release reaction occurs. Edetic Acid 9-13 fibrinogen beta chain Homo sapiens 72-82 6410532-7 1983 In both media, EDTA displaced approximately half of the fibrinogen indicating that deaggregation is not solely dependent on dissociation of fibrinogen from its receptors. Edetic Acid 15-19 fibrinogen beta chain Homo sapiens 56-66 6458117-0 1981 Human fibrinogen binds EDTA and citrate. Edetic Acid 23-27 fibrinogen beta chain Homo sapiens 6-16 104706-0 1977 Influence of NA2-EDTA and some compounds used for dissolution of fibrin clots on the physiochemical properties of fibrinogen and fibrin. Edetic Acid 13-21 fibrinogen beta chain Homo sapiens 114-124 6767512-7 1980 Fibrinogen binding was also virtually absent with platelets that had been incubated with EDTA for 8 min at 37 degrees C and pH 7.8. Edetic Acid 89-93 fibrinogen beta chain Homo sapiens 0-10 7404479-6 1980 Thus, these findings support earlier studies with thrombasthenic and EDTA-treated platelets and with normal platelets at low pH, or in the presence of EDTA to indicate that fibrinogen binding is associated with aggregability but not with platelet shape. Edetic Acid 69-73 fibrinogen beta chain Homo sapiens 173-183 7404479-6 1980 Thus, these findings support earlier studies with thrombasthenic and EDTA-treated platelets and with normal platelets at low pH, or in the presence of EDTA to indicate that fibrinogen binding is associated with aggregability but not with platelet shape. Edetic Acid 151-155 fibrinogen beta chain Homo sapiens 173-183 22551158-6 2012 Fibrinogen concentration was measured in EDTA and heparinized plasma in the manual FIATA. Edetic Acid 41-45 fibrinogen beta chain Homo sapiens 0-10 29296957-0 2017 alphaIIbbeta3 binding to a fibrinogen fragment lacking the gamma-chain dodecapeptide is activation dependent and EDTA inducible. Edetic Acid 113-117 fibrinogen beta chain Homo sapiens 27-37 25308126-6 2015 RESULTS: A statistically and clinically significant prolongation was observed for both APTT and PT between 29% and 43% K2 EDTA contamination, whereas the decrease of fibrinogen values became statistically and clinically significant at 43% K2 EDTA contamination. Edetic Acid 242-246 fibrinogen beta chain Homo sapiens 166-176 25016696-9 2014 We found a moderate correlation between fibrinogen-AOPP and microalbumin-AOPP levels only in the kinetic method (r = 0.644 and 0.520 for citrate-anticoagulated; r = 0.581 and 0.490 for EDTA-anticoagulated, p = 0.0001). Edetic Acid 185-189 fibrinogen beta chain Homo sapiens 40-50 13706166-0 1960 The effect of EDTA on human fibrinogen and its significance for the coagulation of fibrinogen with thrombin. Edetic Acid 14-18 fibrinogen beta chain Homo sapiens 28-38 13706166-0 1960 The effect of EDTA on human fibrinogen and its significance for the coagulation of fibrinogen with thrombin. Edetic Acid 14-18 fibrinogen beta chain Homo sapiens 83-93 22551158-12 2012 CONCLUSIONS: The FIATA can be used as a screening method to measure fibrinogen concentration in citrated or EDTA plasma from dogs. Edetic Acid 108-112 fibrinogen beta chain Homo sapiens 68-78 20850171-3 2010 Trimarin showed proteolytic activity towards casein and fibrinogen, which was irreversibly inhibited by EDTA and 1,10-phenanthroline. Edetic Acid 104-108 fibrinogen beta chain Homo sapiens 56-66 21932842-6 2011 Plasmin digests of HC fibrinogen produced fragments that were similar to normal D and E; further, as with normal fibrinogen, the knob "A" peptide, GPRP, reversed the plasmin cleavage associated with addition of EDTA. Edetic Acid 211-215 fibrinogen beta chain Homo sapiens 22-32 17164498-14 2007 Vancomycin also clouds dysfunctional fibrinogen (fibrinogen in presence of EDTA or chloramine-T)or soluble fibrin. Edetic Acid 75-79 fibrinogen beta chain Homo sapiens 49-59 18605954-0 2008 Can both EDTA and citrate plasma samples be used in measurements of fibrinogen and C-reactive protein concentrations? Edetic Acid 9-13 fibrinogen beta chain Homo sapiens 68-78 18605954-5 2008 RESULTS: In approximately one-third of the samples, the fibrinogen concentration measured by immunoassay was higher in citrate plasma than in EDTA plasma, in spite of the dilution by citrate. Edetic Acid 142-146 fibrinogen beta chain Homo sapiens 56-66 18605954-6 2008 The immunoassay results of fibrinogen concentration measurements in EDTA and citrate plasma differed significantly and also differed from those of functionally measured fibrinogen concentrations. Edetic Acid 68-72 fibrinogen beta chain Homo sapiens 27-37 16776642-5 2006 METHODS: Unselected paired samples were used for comparison between the TEST 1 and Sedimatic 100 methods (n=733); fibrinogen was measured in EDTA samples (n=765) using a turbidimetric method. Edetic Acid 141-145 fibrinogen beta chain Homo sapiens 114-124 17015275-3 2006 Thermal treatment of pooled samples of human citrate-plasma or EDTA-plasma at 50 degrees C resulted in a rapid and parallel loss of fibrinogen concentration and AOPP reactivity. Edetic Acid 63-67 fibrinogen beta chain Homo sapiens 132-142 15081565-0 2004 The viscosity of fibrinogen subfractions and of EDTA denatured fibrinogen do not differ from that of native fibrinogen. Edetic Acid 48-52 fibrinogen beta chain Homo sapiens 63-73 15081565-0 2004 The viscosity of fibrinogen subfractions and of EDTA denatured fibrinogen do not differ from that of native fibrinogen. Edetic Acid 48-52 fibrinogen beta chain Homo sapiens 63-73 15081565-4 2004 The viscosity of plasma is usually determined in ethylenediaminetetra-acetic acid (EDTA) plasma at 37 degrees C. Under such conditions the clotting properties of fibrinogen is affected due to denaturation. Edetic Acid 49-81 fibrinogen beta chain Homo sapiens 162-172 15081565-4 2004 The viscosity of plasma is usually determined in ethylenediaminetetra-acetic acid (EDTA) plasma at 37 degrees C. Under such conditions the clotting properties of fibrinogen is affected due to denaturation. Edetic Acid 83-87 fibrinogen beta chain Homo sapiens 162-172 15081565-6 2004 Therefore, we have also investigated the effects of EDTA on the viscosity of fibrinogen. Edetic Acid 52-56 fibrinogen beta chain Homo sapiens 77-87 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Edetic Acid 108-112 fibrinogen beta chain Homo sapiens 77-87 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Edetic Acid 108-112 fibrinogen beta chain Homo sapiens 210-220 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Edetic Acid 181-185 fibrinogen beta chain Homo sapiens 77-87 15081565-11 2004 A substantial prolongation of the thrombin clotting time was observed in the fibrinogen solution containing EDTA at 37 degrees C compared to 20 degrees C. However, the viscosity of EDTA anticoagulated purified fibrinogen and plasma samples did not differ from that of heparin anticoagulated samples. Edetic Acid 181-185 fibrinogen beta chain Homo sapiens 210-220 11435303-3 2001 Polymerization of purified fibrinogen was strongly impaired in the presence of calcium or ethylenediaminetetraacetic acid (EDTA). Edetic Acid 90-121 fibrinogen beta chain Homo sapiens 27-37 11435303-3 2001 Polymerization of purified fibrinogen was strongly impaired in the presence of calcium or ethylenediaminetetraacetic acid (EDTA). Edetic Acid 123-127 fibrinogen beta chain Homo sapiens 27-37 11153893-3 2000 We have recently observed that the values of fibrinogen measured by thrombin clotting time (the method of Clauss) were consistently lower in EDTA plasma than those obtained with citrated plasma. Edetic Acid 141-145 fibrinogen beta chain Homo sapiens 45-55