PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16481213-3 2006 Mutations in the FMO3 gene can result in defective trimethylamine (TMA) N-oxygenation, which gives rise to the disorder known as trimethylaminuria (TMAU) or "fish-odour syndrome". trimethylamine 51-65 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 17-21 21395651-5 2011 RESULTS: There was a significant correlation between trimethylamine N-oxygenation functional activity and FMO3 expression levels in human liver microsomes (r= 0.71, P < 0.05, n= 9). trimethylamine 53-67 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 106-110 19881207-11 2009 These lines of evidence suggest that individual differences of FMO3 are important determinants for the metabolic fate of dietary-derived trimethylamine. trimethylamine 137-151 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 63-67 19321370-3 2009 In a healthy individual, 95% or more of TMA is converted by the flavin-containing monooxygenase 3 (FMO3, EC 1.14.13.8) to non-odorous trimethylamine N-oxide (TMA N-oxide). trimethylamine 40-43 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 64-97 19321370-3 2009 In a healthy individual, 95% or more of TMA is converted by the flavin-containing monooxygenase 3 (FMO3, EC 1.14.13.8) to non-odorous trimethylamine N-oxide (TMA N-oxide). trimethylamine 40-43 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 99-103 19321370-4 2009 Several single nucleotide polymorphisms (SNPs) of the FMO3 gene have been described and result in an enzyme with decreased or abolished functional activity for TMA N-oxygenation thus leading to TMAu. trimethylamine 160-163 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 54-58 19321370-8 2009 FMO3 variants V187A and V187A/E158K were characterized for oxygenation of several common FMO3 substrates (i.e., 5- and 8-DPT, mercaptoimidazole (MMI), TMA, and sulindac sulfide) and for its thermal stability. trimethylamine 151-154 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 0-4 17257434-3 2007 METHODS: FMO3 metabolic capacity (conversion of trimethylamine to trimethylamine N-oxide) was defined as the urinary ratio of trimethylamine N-oxide to total trimethylamine. trimethylamine 48-62 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 9-13 17257434-3 2007 METHODS: FMO3 metabolic capacity (conversion of trimethylamine to trimethylamine N-oxide) was defined as the urinary ratio of trimethylamine N-oxide to total trimethylamine. trimethylamine 66-80 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 9-13 17050781-4 2007 Using expressed recombinant enzyme with methimazole, trimethylamine, sulindac, and ethylenethiourea, the novel structural variants FMO3 E24D and K416N were shown to cause modest changes in catalytic efficiency, whereas a third novel variant, FMO3 N61K, was essentially devoid of activity. trimethylamine 53-67 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 131-135 17531949-1 2007 Impaired conversion of trimethylamine to trimethylamine N-oxide by human flavin containing monooxygenase 3 (FMO3) is strongly associated with primary trimethylaminuria, also known as "fish-odor" syndrome. trimethylamine 23-37 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 73-106 17531949-1 2007 Impaired conversion of trimethylamine to trimethylamine N-oxide by human flavin containing monooxygenase 3 (FMO3) is strongly associated with primary trimethylaminuria, also known as "fish-odor" syndrome. trimethylamine 23-37 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 108-112 17142560-1 2007 The decreased capacity of the flavin-containing monooxygenase 3 (FMO3) to oxygenate xenobiotics including trimethylamine is believed to contribute to metabolic disorders. trimethylamine 106-120 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 30-63 17142560-1 2007 The decreased capacity of the flavin-containing monooxygenase 3 (FMO3) to oxygenate xenobiotics including trimethylamine is believed to contribute to metabolic disorders. trimethylamine 106-120 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 65-69 17142560-3 2007 Recombinant Glu158Lys and Glu158Lys-Glu308Gly FMO3 expressed in Escherichia coli membranes showed slightly decreased N-oxygenation of benzydamine and trimethylamine. trimethylamine 150-164 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 46-50 17142560-7 2007 However, compared with wild-type FMO3, Val257Met FMO3 showed a similar catalytic efficiency for N-oxygenation of benzydamine and trimethylamine. trimethylamine 129-143 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 33-37 17142560-7 2007 However, compared with wild-type FMO3, Val257Met FMO3 showed a similar catalytic efficiency for N-oxygenation of benzydamine and trimethylamine. trimethylamine 129-143 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 49-53 17142560-8 2007 The catalytic efficiency for benzydamine and trimethylamine N-oxygenation by Arg205Cys FMO3 was only moderately decreased, but it possessed decreased sulindac sulfide S-oxygenation activity. trimethylamine 45-59 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 87-91 12814961-11 2003 The His132-FMO3 variant moderately altered the catalytic efficiency of FMO3 (decrease of 30%, 60% and 6% with methimazole, trimethylamine and 10-(N,N-dimethylaminopentyl)-2-(trifluoromethyl)phenothiazine, respectively). trimethylamine 123-137 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 11-15 16601883-1 2006 Persistent trimethylaminuria in children is caused by autosomal recessively inherited impairment of hepatic trimethylamine (TMA) oxidation due to deficiency of flavin monooxygenase 3 (FMO3) secondary to mutations in the FMO3 gene. trimethylamine 108-122 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 160-182 16601883-1 2006 Persistent trimethylaminuria in children is caused by autosomal recessively inherited impairment of hepatic trimethylamine (TMA) oxidation due to deficiency of flavin monooxygenase 3 (FMO3) secondary to mutations in the FMO3 gene. trimethylamine 108-122 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 184-188 16601883-1 2006 Persistent trimethylaminuria in children is caused by autosomal recessively inherited impairment of hepatic trimethylamine (TMA) oxidation due to deficiency of flavin monooxygenase 3 (FMO3) secondary to mutations in the FMO3 gene. trimethylamine 108-122 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 220-224 12814961-11 2003 The His132-FMO3 variant moderately altered the catalytic efficiency of FMO3 (decrease of 30%, 60% and 6% with methimazole, trimethylamine and 10-(N,N-dimethylaminopentyl)-2-(trifluoromethyl)phenothiazine, respectively). trimethylamine 123-137 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 71-75 12814961-13 2003 Pro360-FMO3 oxygenated methimazole, trimethylamine and 10-(N,N-dimethylaminopentyl)-2-(trifluoromethyl)phenothiazine, respectively, 3-, 5- and 2-fold more efficiently than wild-type FMO3. trimethylamine 36-50 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 7-11 12814961-13 2003 Pro360-FMO3 oxygenated methimazole, trimethylamine and 10-(N,N-dimethylaminopentyl)-2-(trifluoromethyl)phenothiazine, respectively, 3-, 5- and 2-fold more efficiently than wild-type FMO3. trimethylamine 36-50 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 182-186 12678693-4 2003 The genetic variability of the flavin-containing monooxygenase (form 3) that is responsible for detoxication and deodoration of trimethylamine is discussed and put in context with other variant forms of the flavin-containing monooxygenase (forms 1-5). trimethylamine 128-142 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 31-70 11191884-3 2000 Ordinarily, dietary-derived TMA is oxidized to the nonodorous N-oxide by hepatic flavin-containing monooxygenase 3 (FMO3). trimethylamine 28-31 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 81-114 12052141-6 2002 Certain mutations of the human FMO3 gene have been associated with abnormal N-oxygenation of trimethylamine. trimethylamine 93-107 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 31-35 11717182-3 2001 For example, abnormal N-oxygenation of trimethylamine has been shown to segregate with mutations of human FMO3. trimethylamine 39-53 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 106-110 12228178-6 2002 Examples of such interindividual variation come from the study of very rare mutations of the human FMO3 gene that have been associated with deficient N-oxygenation of dietary trimethylamine. trimethylamine 175-189 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 99-103 12214664-2 2002 The major FMO in adult human liver, FMO3, is responsible for trimethylamine (TMA) N-oxygenation. trimethylamine 61-75 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 36-40 11191884-3 2000 Ordinarily, dietary-derived TMA is oxidized to the nonodorous N-oxide by hepatic flavin-containing monooxygenase 3 (FMO3). trimethylamine 28-31 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 116-120 11465082-7 2000 Currently, the most promising non-invasive probe of in vivo human FMO3 functional activity is the formation of trimethylamine N-oxide from trimethylamine that comes from dietary choline. trimethylamine 111-125 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 66-70 10898113-1 2000 We have previously shown that primary trimethylaminuria, or fish-odour syndrome, is caused by an inherited defect in the flavin-containing monooxygenase 3 (FMO3) catalysed N-oxidation of the dietary-derived malodorous amine, trimethylamine (TMA). trimethylamine 225-239 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 156-160 9344459-8 1997 Catalytic activities of mouse and human FMO3 were high toward the substrate methimazole; however, in the presence of trimethylamine and thioacetamide, FMO-dependent methimazole oxidation by both enzymes was reduced by greater than 85%. trimethylamine 117-131 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 40-44 9776311-3 1998 Human FMO3 was by far the most active isoform, exhibiting a turnover number of 30 nmol TMAO/nmol FMO3/min at pH 7.4 and 0.5 mM TMA. trimethylamine 87-90 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 6-10 9776311-3 1998 Human FMO3 was by far the most active isoform, exhibiting a turnover number of 30 nmol TMAO/nmol FMO3/min at pH 7.4 and 0.5 mM TMA. trimethylamine 87-90 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 97-101 9776311-8 1998 Therefore, at physiological pH, human FMO3 is a very specific and efficient TMA N-oxygenase, and is likely responsible for the metabolic clearance of TMA in vivo in humans. trimethylamine 76-79 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 38-42 9776311-9 1998 In addition, this specificity provides a good in vitro probe for the determination of FMO3-mediated activity in human tissues, by analyzing TMAO formation at pH 7.4 with TMA concentrations not higher than 0.5 mM. trimethylamine 140-143 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 86-90 10640514-3 2000 For example, the tertiary amine trimethylamine is N-oxygenated by human FMO3 to trimethylamine N-oxide, and trimethylamine N-oxide is excreted in a detoxication and deoderation process. trimethylamine 32-46 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 72-76 10640514-10 2000 Thus, for polymorphic forms of human FMO3, lower k(cat)/K(m) values for N-oxygenation of 10-(N, N-dimethylaminopentyl)-2-(trifluoromethyl) phenothiazine, trimethylamine, and tyramine were observed. trimethylamine 154-168 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 37-41 34597008-2 2021 The condition is caused by a homozygous mutation in the FMO3 (flavin monooxygenase 3) gene coding for the enzyme that converts TMA (trimethylamine) to trimethylamine N-oxide. trimethylamine 127-130 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 56-60 34597008-2 2021 The condition is caused by a homozygous mutation in the FMO3 (flavin monooxygenase 3) gene coding for the enzyme that converts TMA (trimethylamine) to trimethylamine N-oxide. trimethylamine 127-130 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 62-84 34597008-2 2021 The condition is caused by a homozygous mutation in the FMO3 (flavin monooxygenase 3) gene coding for the enzyme that converts TMA (trimethylamine) to trimethylamine N-oxide. trimethylamine 132-146 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 56-60 34597008-2 2021 The condition is caused by a homozygous mutation in the FMO3 (flavin monooxygenase 3) gene coding for the enzyme that converts TMA (trimethylamine) to trimethylamine N-oxide. trimethylamine 132-146 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 62-84 35065293-2 2022 The conversion of TMA to TMAO is mainly catalyzed by flavin-containing monooxygenases 3 (FMO3) and FMO1. trimethylamine 18-21 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 53-87 35065293-2 2022 The conversion of TMA to TMAO is mainly catalyzed by flavin-containing monooxygenases 3 (FMO3) and FMO1. trimethylamine 18-21 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 89-93 35084335-8 2022 We show the gut microbial choline metabolite trimethylamine (TMA) is elevated in AH patients and correlates with reduced hepatic expression of the TMA oxygenase flavin-containing monooxygenase 3 (FMO3). trimethylamine 45-59 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 196-200 33831674-1 2021 The oxygenation of food-derived trimethylamine to its N-oxide is a representative reaction mediated by human flavin-containing monooxygenase 3 (FMO3). trimethylamine 32-46 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 109-142 33831674-1 2021 The oxygenation of food-derived trimethylamine to its N-oxide is a representative reaction mediated by human flavin-containing monooxygenase 3 (FMO3). trimethylamine 32-46 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 144-148 33831674-8 2021 Although the present novel mutations or alleles were relatively rare, both in self-reported Japanese trimethylaminuria sufferers and in the genomic database panel, three common FMO3 missense or deletion variants severely impaired FMO3-mediated N-oxygenation of trimethylamine. trimethylamine 261-275 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 177-181 33831674-8 2021 Although the present novel mutations or alleles were relatively rare, both in self-reported Japanese trimethylaminuria sufferers and in the genomic database panel, three common FMO3 missense or deletion variants severely impaired FMO3-mediated N-oxygenation of trimethylamine. trimethylamine 261-275 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 230-234 33746664-3 2021 It is formed by the process of oxidation of trimethylamine (TMA) by the hepatic flavin monooxygenases (FMO1 and FMO3). trimethylamine 44-58 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 112-116 33247860-1 2021 WHAT IS KNOWN AND OBJECTIVE: Trimethylaminuria is a metabolic disorder characterized by excessive excretion of trimethylamine in body fluids following FMO3 gene mutations. trimethylamine 111-125 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 151-155 32587943-2 2020 The trimethylamine N-oxide (TMAO) metaorganismal pathway is the most deeply investigated one, which comprises trimethylamine precursors, such as choline, trimethylamine lyase, trimethylamine, host liver FMO3, TMAO, and downstream effectors involving unfolded protein response (UPR), NF-kappaB and NLRP3 inflammasome. trimethylamine 4-18 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 203-207 32653296-8 2020 This is the first report and characterization of a patient of fish odor syndrome caused by genetic aberrations leading to impaired FMO3-dependent N-oxygenation of trimethylamine found in the Argentinian population. trimethylamine 163-177 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 131-135 32587943-2 2020 The trimethylamine N-oxide (TMAO) metaorganismal pathway is the most deeply investigated one, which comprises trimethylamine precursors, such as choline, trimethylamine lyase, trimethylamine, host liver FMO3, TMAO, and downstream effectors involving unfolded protein response (UPR), NF-kappaB and NLRP3 inflammasome. trimethylamine 110-124 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 203-207 30814476-4 2019 Human flavin-containing monooxygenase 3 (FMO3), which is the major hepatic enzyme involved in the production of N-oxide of trimethylamine, catalyzes the oxygenation of a variety of drug compounds. trimethylamine 123-137 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 6-39 30351217-10 2019 These variant FMO3 proteins recombinantly expressed in Escherichia coli membranes exhibited decreased N-oxygenation activities toward trimethylamine (Vmax/Km < 40% that of the wild-type). trimethylamine 134-148 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 14-18 30351217-12 2019 Although the allele frequencies of the six new variants and/or haplotypes were low, the present results indicated that individuals homozygous or heterozygous for any of these novel missense FMO3 variants or known nonsense mutations such as p.(Cys197Ter) or p.(Arg205Cys) highly found in this self-reported Japanese trimethylaminuria cohort may have reduced FMO3 activity with respect to the N-oxygenation of trimethylamine. trimethylamine 408-422 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 190-194 31401033-7 2019 Recombinant FMO3 proteins of the above and unanalyzed variants underwent kinetic analysis of their trimethylamine/benzydamine N-oxygenation activities. trimethylamine 99-113 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 12-16 30814476-4 2019 Human flavin-containing monooxygenase 3 (FMO3), which is the major hepatic enzyme involved in the production of N-oxide of trimethylamine, catalyzes the oxygenation of a variety of drug compounds. trimethylamine 123-137 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 41-45 30347638-2 2018 Gut microbial metabolism of choline and l-carnitine results in the formation of trimethylamine (TMA) and concomitant conversion into trimethylamine-N-oxide (TMAO) by liver flavin monooxygenase 3 (FMO3). trimethylamine 80-94 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 172-194 30347638-2 2018 Gut microbial metabolism of choline and l-carnitine results in the formation of trimethylamine (TMA) and concomitant conversion into trimethylamine-N-oxide (TMAO) by liver flavin monooxygenase 3 (FMO3). trimethylamine 80-94 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 196-200 29116146-0 2017 Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine. trimethylamine 60-74 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 47-51 29116146-3 2017 Certain mutations within the hFMO3 gene cause defective trimethylamine (TMA) N-oxygenation leading to trimethylaminuria (TMAU) also known as fish-odour syndrome. trimethylamine 72-75 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 29-34 29116146-3 2017 Certain mutations within the hFMO3 gene cause defective trimethylamine (TMA) N-oxygenation leading to trimethylaminuria (TMAU) also known as fish-odour syndrome. trimethylamine 56-70 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 29-34 27513517-2 2016 TMAO is generated from trimethylamine (TMA) via metabolism by hepatic flavin-containing monooxygenase isoform 3 (FMO3). trimethylamine 23-37 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 70-111 28819071-1 2017 Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of nucleophilic heteroatom (e.g., N or S)-containing xenobiotics (e.g., amphetamine, sulindac, benzydamine, ranitidine, tamoxifen, nicotine, and ethionamide), as well as endogenous compounds (e.g., catecholamine and trimethylamine). trimethylamine 292-306 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 0-42 28819071-1 2017 Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of nucleophilic heteroatom (e.g., N or S)-containing xenobiotics (e.g., amphetamine, sulindac, benzydamine, ranitidine, tamoxifen, nicotine, and ethionamide), as well as endogenous compounds (e.g., catecholamine and trimethylamine). trimethylamine 292-306 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 44-48 28196478-1 2017 BACKGROUND: Trimethylaminuria (TMAU) is a genetic disorder whereby people cannot convert trimethylamine (TMA) to its oxidized form (TMAO), a process that requires the liver enzyme FMO3. trimethylamine 89-103 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 180-184 28196478-1 2017 BACKGROUND: Trimethylaminuria (TMAU) is a genetic disorder whereby people cannot convert trimethylamine (TMA) to its oxidized form (TMAO), a process that requires the liver enzyme FMO3. trimethylamine 31-34 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 180-184 27806989-0 2016 Correction to "Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease". trimethylamine 15-29 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 60-93 27806989-0 2016 Correction to "Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease". trimethylamine 15-29 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 95-99 27523475-5 2016 This was followed by structural mapping of 12 critical polymorphic variants and molecular docking experiments with five different known substrates/drugs of hFMO3 namely, benzydamine, sulindac sulfide, tozasertib, methimazole and trimethylamine. trimethylamine 229-243 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 156-161 27190056-0 2016 Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease. trimethylamine 0-14 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 45-78 27190056-0 2016 Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease. trimethylamine 0-14 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 80-84 27190056-3 2016 FMO3 converts the odorous TMA to nonodorous TMA N-oxide (TMAO), which is excreted in urine. trimethylamine 26-29 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 0-4 27513517-2 2016 TMAO is generated from trimethylamine (TMA) via metabolism by hepatic flavin-containing monooxygenase isoform 3 (FMO3). trimethylamine 23-37 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 113-117 25288227-1 2014 INTRODUCTION: Trimethylaminuria is a rare inherited disorder due to decreased metabolism of dietary-derived trimethylamine by flavin-containing monooxygenase 3. trimethylamine 108-122 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 126-159 28649550-9 2015 These variant FMO3 proteins recombinantly expressed in Escherichia coli membranes exhibited decreased N-oxygenation activities toward trimethylamine and benzydamine. trimethylamine 134-148 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 14-18 25460299-3 2014 FMO3 mutations have been associated with the incidence and severity of trimethylaminuria (TMAU), a metabolic disorder characterized by the inability of the affected individual to metabolize the odorous trimethylamine to its non-odorous N-oxide. trimethylamine 202-216 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 0-4 25288227-2 2014 Several single nucleotide polymorphisms of the flavin-containing monooxygenase 3 gene have been described and result in an enzyme with decreased or abolished functional activity for trimethylamine N-oxygenation thus leading to trimethylaminuria. trimethylamine 182-196 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 47-80 23791655-1 2013 Trimethylaminuria (TMAu) or "fish odor syndrome" is a metabolic disorder characterized by the inability to convert malodorous dietarily-derived trimethylamine (TMA) to odorless TMA N-oxide by the flavin-containing monooxygenase 3 (FMO3). trimethylamine 19-22 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 231-235 24028545-1 2014 AIM: The aim of this study was to investigate relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and phenotype (conversion of odorous trimethylamine into non-odorous trimethylamine N-oxide) in a large Japanese cohort suffering from trimethylaminuria. trimethylamine 156-170 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 68-102 24028545-1 2014 AIM: The aim of this study was to investigate relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and phenotype (conversion of odorous trimethylamine into non-odorous trimethylamine N-oxide) in a large Japanese cohort suffering from trimethylaminuria. trimethylamine 156-170 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 104-108 23656565-4 2013 Dietary carnitine (present predominately in red meat) and lecithin (phosphatidyl choline) are shown to be metabolized by gut microbes to trimethylamine (TMA), which in turn is metabolized by liver flavin monoxygenases (especially FMO3 and FMO1) to form trimethylamine-N-oxide (TMAO). trimethylamine 137-151 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 230-234 23266626-3 2013 Several single nucleotide polymorphisms (SNPs) of the FMO3 gene have been described and result in an enzyme with decreased or abolished functional activity for TMA N-oxygenation thus leading to TMAU, or fish-like odor syndrome. trimethylamine 160-163 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 54-58 23266626-12 2013 Urinary determination of TMA/TMAO ratio in 158KK/308EG individuals showed a considerable reduction in FMO3 activity although they do not show the classical features of trimethylaminuria as a strong body odor and breath. trimethylamine 25-28 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 102-106 23211429-2 2013 Rare mutations in FMO3 are responsible for defective N-oxidation of dietary trimethylamine leading to trimethylaminuria, and common genetic variation in FMO3 has been linked to interindividual variability in metabolic function that may be substrate specific. trimethylamine 76-90 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 18-22 23430514-1 2013 INTRODUCTION: Trimethylaminuria is a malodour syndrome caused by a functional defect of flavin-containing monoxygenase 3 (FMO3), resulting in accumulation of trimethylamine in body secretions. trimethylamine 158-172 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 88-120 23430514-1 2013 INTRODUCTION: Trimethylaminuria is a malodour syndrome caused by a functional defect of flavin-containing monoxygenase 3 (FMO3), resulting in accumulation of trimethylamine in body secretions. trimethylamine 158-172 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 122-126