PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35260558-0	2022	Hepatoprotective effects of sevoflurane against hepatic ischemia-reperfusion injury by regulating microRNA-124-3p-mediated TRAF3/CREB axis.	Sevoflurane	28-39	cAMP responsive element binding protein 1	Mus musculus	129-133	
33982674-7	2021	Sevoflurane treatment or silencing RASD1 reduced RASD1 expression, CK, LDH and MDA contents, inflammation, apoptosis, but increased proliferation, SOD content, cAMP expression, and extents of PKA and cAMP responsive element binding protein (CREB) phosphorylation in skeletal muscle cells of I/R injury.	Sevoflurane	0-11	cAMP responsive element binding protein 1	Mus musculus	200-239	
33982674-7	2021	Sevoflurane treatment or silencing RASD1 reduced RASD1 expression, CK, LDH and MDA contents, inflammation, apoptosis, but increased proliferation, SOD content, cAMP expression, and extents of PKA and cAMP responsive element binding protein (CREB) phosphorylation in skeletal muscle cells of I/R injury.	Sevoflurane	0-11	cAMP responsive element binding protein 1	Mus musculus	241-245	
32271540-6	2020	Mechanistically, BRL-50481 administration suppressed sevoflurane-induced neurodegenerative disorders through restoring cAMP and activating cAMP/CREB signaling in the hippocampus.	Sevoflurane	53-64	cAMP responsive element binding protein 1	Mus musculus	144-148	
29434807-8	2018	Sevoflurane inhibited the phosphorylation of ERK1/2 and CREB, stimulated the phosphorylation of p38 and NF-kappaB, but did not significantly affect the phosphorylation of JNK.	Sevoflurane	0-11	cAMP responsive element binding protein 1	Mus musculus	56-60	
29141245-0	2017	Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3beta and ERK/PPARgamma/CREB Signaling.	Sevoflurane	42-53	cAMP responsive element binding protein 1	Mus musculus	130-134	
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	Sevoflurane	82-93	cAMP responsive element binding protein 1	Mus musculus	143-147	
28679060-8	2017	Sevoflurane-mediated downregulation of cAMP/CREB and BDNF/TrkB signalling was inhibited by EGCG.	Sevoflurane	0-11	cAMP responsive element binding protein 1	Mus musculus	44-48	
28679060-11	2017	The study indicates that EGCG was able to effectively inhibit sevoflurane-induced neurodegeneration and improve learning and memory retention of mice via activation of CREB/BDNF/TrkB-PI3K/Akt signalling.	Sevoflurane	62-73	cAMP responsive element binding protein 1	Mus musculus	168-172