PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33798536-1 2021 HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (DDS-NO). Fumigant 93 40-43 CD8a molecule Homo sapiens 106-109 33798536-1 2021 HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (DDS-NO). Fumigant 93 136-139 CD8a molecule Homo sapiens 106-109 33798536-4 2021 CD8+ TCC were stimulated to proliferate and secrete effector molecules when exposed to DDS and/or DDS-NO. Fumigant 93 87-90 CD8a molecule Homo sapiens 0-3 33798536-9 2021 To conclude, DDS and DDS-NO interact with a number of HLA molecules to activate CD8+ TCC, with HLA class-II-restricted CD8+ TCC that display hybrid CD4/CD8 features also contributing to the promiscuous immune response that develops in patients. Fumigant 93 13-16 CD8a molecule Homo sapiens 80-83