PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2882415-5 1987 An increase in glutamine synthetase mRNA is also observed within 2 h of incubation of retinal organ cultures with hydrocortisone. Hydrocortisone 114-128 glutamate-ammonia ligase Gallus gallus 15-35 2891717-2 1987 Hydrocortisone (Kapp = 3-4 nM) and dexamethasone (Kapp = 1-2 nM) produce an approximate 30-fold increase in glutamine synthetase mRNA after incubation of organ cultures derived from embryonic day 12 retinae with either hormone for 3 hr. Hydrocortisone 0-14 glutamate-ammonia ligase Gallus gallus 108-128 6140294-5 1983 Glial markers such as carbonic anhydrase and hydrocortisone-induced glutamine synthetase activities are also expressed only transiently in culture. Hydrocortisone 45-59 glutamate-ammonia ligase Gallus gallus 68-88 2878430-1 1986 Glutamine synthetase (GS) is expressed in the neural retina only in Muller glia cells and is inducible with cortisol. Hydrocortisone 108-116 glutamate-ammonia ligase Gallus gallus 0-20 2880646-0 1987 Glutamine synthetase and energy metabolism enzymes in cultivated chick neurons and astrocytes: modulation by serum and hydrocortisone. Hydrocortisone 119-133 glutamate-ammonia ligase Gallus gallus 0-20 2859535-0 1985 Glutamine synthetase and energy metabolism enzymes in cultured chick glial cells: modulation by dibutyryl cyclic AMP, hydrocortisone, and trypsinization. Hydrocortisone 118-132 glutamate-ammonia ligase Gallus gallus 0-20 6194421-6 1983 In the retina, hydrocortisone (HC) elicits an age-related and transcription-dependent induction of GS by enhancing the level of GS mRNA in the polysomes through an increased supply of this mRNA from the nucleus. Hydrocortisone 15-29 glutamate-ammonia ligase Gallus gallus 99-101 6131848-1 1983 Cortisol induces glutamine synthetase (GS) in gliocytes of chick embryo neural retina. Hydrocortisone 0-8 glutamate-ammonia ligase Gallus gallus 17-37 6194421-6 1983 In the retina, hydrocortisone (HC) elicits an age-related and transcription-dependent induction of GS by enhancing the level of GS mRNA in the polysomes through an increased supply of this mRNA from the nucleus. Hydrocortisone 31-33 glutamate-ammonia ligase Gallus gallus 99-101 6167358-1 1981 Induction of glutamine synthetase (GS) by cortisol has been shown to occur in monolayer cultures of cells obtained by enzymatic dissociation of retinas from 8- and 12-day-old chick embryos with papain (0.1%) or trypsin (0.25%). Hydrocortisone 42-50 glutamate-ammonia ligase Gallus gallus 13-33 7158537-5 1982 Glutamine synthetase activity (a glial marker) is inducible by hydrocortisone in dense neuro-retinal cultures, and this hormone also reduces the extent of later lens development. Hydrocortisone 63-77 glutamate-ammonia ligase Gallus gallus 0-20 6125450-2 1982 A glial marker (glutamine synthetase, GSase) is precociously inducible by hydrocortisone (HC) in dens "monolayer" NR cultures (containing aggregates of neuronal cells overlying the glian sheet) as well as in chick embryo retinal explants. Hydrocortisone 74-88 glutamate-ammonia ligase Gallus gallus 16-36 6121769-1 1982 Responsiveness of the neural retina to cortisol, as measured by cortisol-induced glutamine synthetase activity, is acquired in the chick embryo during the second week of embryogenesis. Hydrocortisone 39-47 glutamate-ammonia ligase Gallus gallus 81-101 6121769-1 1982 Responsiveness of the neural retina to cortisol, as measured by cortisol-induced glutamine synthetase activity, is acquired in the chick embryo during the second week of embryogenesis. Hydrocortisone 64-72 glutamate-ammonia ligase Gallus gallus 81-101 6109754-6 1981 The present work thus confirms reports in the literature that hydrocortisone induces glutamine synthetase in neural tissues, but differs from the findings of Moscona and co-workers in the chick retina that intact tissues are required for the induction to occur. Hydrocortisone 62-76 glutamate-ammonia ligase Gallus gallus 85-105 6110468-1 1981 Competence for cortisol-mediated induction of glutamine synthetase (GS) is a differentiation marker of embryonic neural retina. Hydrocortisone 15-23 glutamate-ammonia ligase Gallus gallus 46-66 6120796-4 1981 Addition of kainate, an analogue of glutamate, enhances cortisol induction of glutamine synthetase by a factor of 2 under similar conditions. Hydrocortisone 56-64 glutamate-ammonia ligase Gallus gallus 78-98 6102095-0 1980 Glutamine synthetase localization in cortisol-induced chick embryo retinas. Hydrocortisone 37-45 glutamate-ammonia ligase Gallus gallus 0-20 6102095-2 1980 Age-dependent changes in the endogenous enzyme activity as well as cortisol-induced changes in GS activity, both in ovo and in vitro, measured biochemically, reflect the changes observed by staining. Hydrocortisone 67-75 glutamate-ammonia ligase Gallus gallus 95-97 6101268-0 1980 The relation between cortisol binding and glutamine synthetase induction in the neural retina of the chick embryo. Hydrocortisone 21-29 glutamate-ammonia ligase Gallus gallus 42-62 44249-1 1979 The hydrocortisone-mediated induction of glutamine synthetase (GS) in the neural retina of the chick embryo is a characteristic and unique feature of differentiation of this tissue. Hydrocortisone 4-18 glutamate-ammonia ligase Gallus gallus 41-61 42916-1 1979 The cellular localization of glutamine synthetase [GSase; L-glutamate:ammonia ligase(ADP)-forming), EC 6.3.1.2] induced by cortisol in the neural retina of chicken embryos was investigated by immunostaining with GSase-specific antiserum and indirect immunofluorescence. Hydrocortisone 123-131 glutamate-ammonia ligase Gallus gallus 29-49 42916-1 1979 The cellular localization of glutamine synthetase [GSase; L-glutamate:ammonia ligase(ADP)-forming), EC 6.3.1.2] induced by cortisol in the neural retina of chicken embryos was investigated by immunostaining with GSase-specific antiserum and indirect immunofluorescence. Hydrocortisone 123-131 glutamate-ammonia ligase Gallus gallus 51-56 42916-1 1979 The cellular localization of glutamine synthetase [GSase; L-glutamate:ammonia ligase(ADP)-forming), EC 6.3.1.2] induced by cortisol in the neural retina of chicken embryos was investigated by immunostaining with GSase-specific antiserum and indirect immunofluorescence. Hydrocortisone 123-131 glutamate-ammonia ligase Gallus gallus 212-217 23177-1 1978 Effect of chick interferon on the biosynthesis of glutamine synthetase (L-glutamate: ammonia ligase (ADP-forming), EC 6.3.1.2) was studied in the embryonic chick neural retina cultures induced for the enzyme activity by hydrocortisone. Hydrocortisone 220-234 glutamate-ammonia ligase Gallus gallus 50-70 28258-0 1978 Control of glutamine synthetase messenger RNA by hydrocortisone in the embryonic chick retina. Hydrocortisone 49-63 glutamate-ammonia ligase Gallus gallus 11-31 15942-0 1977 Early events in the induction of glutamine synthetase activity by hydrocortisone in embryonic chick neural retina. Hydrocortisone 66-80 glutamate-ammonia ligase Gallus gallus 33-53 15942-1 1977 Primary cultures of 10-day embryonic chick neural retinas were used to investigate early aspects of the mechanism of hydrocortisone action on glutamine synthetase activity. Hydrocortisone 117-131 glutamate-ammonia ligase Gallus gallus 142-162 15942-2 1977 As little as 2 hr of hydrocortisone exposure served to initiate significant increases in the glutamine synthetase activity levels assayed after 24 hr culture. Hydrocortisone 21-35 glutamate-ammonia ligase Gallus gallus 93-113 15942-5 1977 The evidence suggests a mechanism of hydrocortisone action involving the production of a protein which is important for the induction of glutamine synthetase activity by hydrocortisone. Hydrocortisone 37-51 glutamate-ammonia ligase Gallus gallus 137-157 15942-5 1977 The evidence suggests a mechanism of hydrocortisone action involving the production of a protein which is important for the induction of glutamine synthetase activity by hydrocortisone. Hydrocortisone 170-184 glutamate-ammonia ligase Gallus gallus 137-157 236836-4 1975 Cortisol binding to specific receptors in the cytosol shows a sigmoidal type of kinetics which correlates well with the kinetics of glutamine-synthetase induction by cortisol. Hydrocortisone 0-8 glutamate-ammonia ligase Gallus gallus 132-152 236836-4 1975 Cortisol binding to specific receptors in the cytosol shows a sigmoidal type of kinetics which correlates well with the kinetics of glutamine-synthetase induction by cortisol. Hydrocortisone 166-174 glutamate-ammonia ligase Gallus gallus 132-152 4398761-0 1971 Actinomycin-D enhancement of glutamine synthetase activity in chick embryo retinas cultured in the presence of cortisol. Hydrocortisone 111-119 glutamate-ammonia ligase Gallus gallus 29-49 4399928-1 1971 The hydrocortisone-mediated induction of glutamine synthetase in the neural retina of chicken embryo in vitro is correlated with enhanced incorporation into protein of [(14)C]aspartic acid, an amino acid abundant in this enzyme. Hydrocortisone 4-18 glutamate-ammonia ligase Gallus gallus 41-61 5637352-0 1968 Hydrocortisone requirement for the induction of glutamine synthetase in chick-embryo retinas. Hydrocortisone 0-14 glutamate-ammonia ligase Gallus gallus 48-68 5637352-1 1968 Hydrocortisone has been found to induce glutamine synthetase activity in chick-embryo retinas in culture. Hydrocortisone 0-14 glutamate-ammonia ligase Gallus gallus 40-60 14046-2 1977 In the neural retina of the chick embryo, hydrocortisone (HC) elicits differential gene expression resulting in the induction of glutamine synthetase (GS), which is an enzyme marker of differentiation in the retina. Hydrocortisone 42-56 glutamate-ammonia ligase Gallus gallus 129-149 14046-2 1977 In the neural retina of the chick embryo, hydrocortisone (HC) elicits differential gene expression resulting in the induction of glutamine synthetase (GS), which is an enzyme marker of differentiation in the retina. Hydrocortisone 58-60 glutamate-ammonia ligase Gallus gallus 129-149