PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15811876-10 2005 Pulsatile leptin independently predicted urine free cortisol/creatinine (15% of variability). Hydrocortisone 52-60 leptin Homo sapiens 10-16 24862904-9 2014 Leptin is likely involved in behavioral regulation as leptin receptors are widely distributed in the brain, and leptin influences cortisol release, the mesoaccumbens dopamine pathway, serotonin synthesis, and hippocampal synaptic plasticity. Hydrocortisone 130-138 leptin Homo sapiens 112-118 20386086-14 2010 A complicated postoperative course is associated with lower leptin levels which are inversely correlated with cortisol levels. Hydrocortisone 110-118 leptin Homo sapiens 60-66 16537679-0 2006 Inhibiting endogenous cortisol blunts the meal-entrained rise in serum leptin. Hydrocortisone 22-30 leptin Homo sapiens 71-77 16459453-5 2005 In a second model, including body fat and exercise, the levels of body fat, gender, free triidothyronine and cortisol explained 59.6% of the variance in leptin (p <0.05). Hydrocortisone 109-117 leptin Homo sapiens 153-159 21631989-8 2011 Serum cortisol levels was significantly correlated with serum leptin (r=0.33, p < 0.05), cholesterol (r=0.35, p < 0.05), triglyceride (r=0.25, p < 0.05), waist circumference (r=0.41, p < 0.01) and waist-to-hip ratio (r=0.32, p < 0.01) in women with metabolic syndrome, after controlling for age and BMI. Hydrocortisone 6-14 leptin Homo sapiens 62-68 17409602-3 2007 However, the serum leptin level was markedly high (24.8 ng/ml) before the operation and decreased to within the normal range (6.0 ng/ml) 6 months after adrenalectomy, concomitant with weight reduction and normalization of the serum cortisol level. Hydrocortisone 232-240 leptin Homo sapiens 19-25 16537679-13 2006 Administering a single dose of hydrocortisone to MET subjects potently stimulated serum leptin compared with the effect of MET alone. Hydrocortisone 31-45 leptin Homo sapiens 88-94 15988695-3 2005 We therefore assessed energy consumption during administration of hydrocortisone (HC), a known leptin secretagogue. Hydrocortisone 66-80 leptin Homo sapiens 95-101 15985478-11 2005 CONCLUSIONS: We conclude that metyrapone-induced inhibition of cortisol biosynthesis results in hypoleptinemia, which indicates that glucocorticoids may play an important role in the physiological regulation of leptin. Hydrocortisone 63-71 leptin Homo sapiens 100-106 15985478-0 2005 Inhibition of cortisol biosynthesis decreases circulating leptin levels in obese humans. Hydrocortisone 14-22 leptin Homo sapiens 58-64 11321513-10 2001 The postprandial rise in plasma leptin was accompanied by a marked increment in gut hormones; gastrin, CCK and PP and stress hormones such as norepinephrine, cortisol and GH. Hydrocortisone 158-166 leptin Homo sapiens 32-38 15621548-10 2004 These results demonstrate for the first time that leptin concentrations in the umbilical vessels at normal vaginal delivery correlate significantly with cortisol values, thus providing evidence that cortisol mediates a labour stimulating effect on fetal leptin secretion. Hydrocortisone 153-161 leptin Homo sapiens 50-56 15621548-10 2004 These results demonstrate for the first time that leptin concentrations in the umbilical vessels at normal vaginal delivery correlate significantly with cortisol values, thus providing evidence that cortisol mediates a labour stimulating effect on fetal leptin secretion. Hydrocortisone 199-207 leptin Homo sapiens 50-56 15621548-10 2004 These results demonstrate for the first time that leptin concentrations in the umbilical vessels at normal vaginal delivery correlate significantly with cortisol values, thus providing evidence that cortisol mediates a labour stimulating effect on fetal leptin secretion. Hydrocortisone 199-207 leptin Homo sapiens 254-260 15212658-8 2004 The heritability of leptin was significantly lowered to 63.8% (P = 0.012) when values were corrected for the influence of total cortisol metabolites but unaffected by markers of 11HSD and 5alpha-reductase activity. Hydrocortisone 128-136 leptin Homo sapiens 20-26 11748524-11 2001 Cortisol levels were inversely correlated to leptin levels (p = 0.016). Hydrocortisone 0-8 leptin Homo sapiens 45-51 11457781-1 2001 We postulated that high circulating cortisol levels during intense exercise would lead to increased serum leptin concentrations. Hydrocortisone 36-44 leptin Homo sapiens 106-112 11502803-4 2001 The negative correlation, with cortisol leading leptin by 4 and 3 h for boys and girls, respectively, might reflect the stimulatory effect of CRH on the sympathetic system, which inhibits leptin secretion; the positive correlation, with leptin leading cortisol by 6 and 5 h for boys and girls, respectively, might reflect a direct effect of leptin on CRH secretion in the hypophyseal portal system. Hydrocortisone 31-39 leptin Homo sapiens 48-54 11502803-4 2001 The negative correlation, with cortisol leading leptin by 4 and 3 h for boys and girls, respectively, might reflect the stimulatory effect of CRH on the sympathetic system, which inhibits leptin secretion; the positive correlation, with leptin leading cortisol by 6 and 5 h for boys and girls, respectively, might reflect a direct effect of leptin on CRH secretion in the hypophyseal portal system. Hydrocortisone 31-39 leptin Homo sapiens 188-194 11502803-4 2001 The negative correlation, with cortisol leading leptin by 4 and 3 h for boys and girls, respectively, might reflect the stimulatory effect of CRH on the sympathetic system, which inhibits leptin secretion; the positive correlation, with leptin leading cortisol by 6 and 5 h for boys and girls, respectively, might reflect a direct effect of leptin on CRH secretion in the hypophyseal portal system. Hydrocortisone 31-39 leptin Homo sapiens 188-194 11502803-4 2001 The negative correlation, with cortisol leading leptin by 4 and 3 h for boys and girls, respectively, might reflect the stimulatory effect of CRH on the sympathetic system, which inhibits leptin secretion; the positive correlation, with leptin leading cortisol by 6 and 5 h for boys and girls, respectively, might reflect a direct effect of leptin on CRH secretion in the hypophyseal portal system. Hydrocortisone 31-39 leptin Homo sapiens 188-194 11453960-0 2001 Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion. Hydrocortisone 100-114 leptin Homo sapiens 118-124 11453960-8 2001 We measured plasma leptin after 28 days treatment with hydrocortisone and after 28 days treatment with placebo. Hydrocortisone 55-69 leptin Homo sapiens 19-25 11453960-10 2001 Hydrocortisone treatment, for both doses combined, caused a significant increase in leptin levels compared to placebo. Hydrocortisone 0-14 leptin Homo sapiens 84-90 11453960-12 2001 We also compared the hydrocortisone induced increase in leptin between those who were deemed treatment-responders and those deemed nonresponders. Hydrocortisone 21-35 leptin Homo sapiens 56-62 11453960-13 2001 Responders showed a significantly greater hydrocortisone-induced rise in leptin than nonresponders. Hydrocortisone 42-56 leptin Homo sapiens 73-79 11453960-14 2001 This association between a clinical response to hydrocortisone and a greater rise in leptin levels may indicate a greater biological effect of hydrocortisone in these subjects, perhaps due to increased glucocorticoid receptor sensitivity, which may be present in some patients with CFS. Hydrocortisone 48-62 leptin Homo sapiens 85-91 11453960-14 2001 This association between a clinical response to hydrocortisone and a greater rise in leptin levels may indicate a greater biological effect of hydrocortisone in these subjects, perhaps due to increased glucocorticoid receptor sensitivity, which may be present in some patients with CFS. Hydrocortisone 143-157 leptin Homo sapiens 85-91 11453960-15 2001 CONCLUSIONS: We conclude that, while we found no evidence of alterations in leptin levels in CFS, low dose hydrocortisone therapy caused increases in plasma leptin levels, with this biological response being more marked in those CFS subjects who showed a positive therapeutic response to hydrocortisone therapy. Hydrocortisone 107-121 leptin Homo sapiens 157-163 11453960-15 2001 CONCLUSIONS: We conclude that, while we found no evidence of alterations in leptin levels in CFS, low dose hydrocortisone therapy caused increases in plasma leptin levels, with this biological response being more marked in those CFS subjects who showed a positive therapeutic response to hydrocortisone therapy. Hydrocortisone 288-302 leptin Homo sapiens 157-163 11453960-16 2001 Increases in plasma leptin levels following low dose hydrocortisone therapy may be a marker of pretreatment physiological hypocortisolism and of response to therapy. Hydrocortisone 53-67 leptin Homo sapiens 20-26 11428717-7 2001 The multiple regression analysis using delta leptin as dependent and the basal values of the rest of studied parameters as independent variables revealed that in lean subjects serum cortisol together with DHEA-S and BMI accounted for 71% of variations of the change of serum leptin levels (delta leptin = 0.31- 0.0101 cortisol + 0.0012 DHEA-S + 0.37 BMI). Hydrocortisone 182-190 leptin Homo sapiens 45-51 11428717-7 2001 The multiple regression analysis using delta leptin as dependent and the basal values of the rest of studied parameters as independent variables revealed that in lean subjects serum cortisol together with DHEA-S and BMI accounted for 71% of variations of the change of serum leptin levels (delta leptin = 0.31- 0.0101 cortisol + 0.0012 DHEA-S + 0.37 BMI). Hydrocortisone 182-190 leptin Homo sapiens 275-281 11428717-7 2001 The multiple regression analysis using delta leptin as dependent and the basal values of the rest of studied parameters as independent variables revealed that in lean subjects serum cortisol together with DHEA-S and BMI accounted for 71% of variations of the change of serum leptin levels (delta leptin = 0.31- 0.0101 cortisol + 0.0012 DHEA-S + 0.37 BMI). Hydrocortisone 182-190 leptin Homo sapiens 275-281 12959996-8 2003 There was a significant reduction (by paired analysis) in the responses of the leptin compared with saline-treated animals: 47% for TNF-alpha, 48% for IL-6, 30% for IL1ra, 42% for ACTH, and 22% for cortisol (P < 0.05). Hydrocortisone 198-206 leptin Homo sapiens 79-85 12582219-1 2003 OBJECTIVE: To examine the effects of graded doses of hydrocortisone (HC) on leptin secretion, and determine the effect of fasting. Hydrocortisone 53-67 leptin Homo sapiens 76-82 15106467-12 2003 The decrease of serum leptin in women without any changes in men could have been mediated by gender differences in body fat tissue as well as hormonal (influence of catecholamins, cortisol, thyroid hormones and growth hormone on adipose tissue, augmentation of testosterone in men) and peripheral mechanisms (decrease of glucose or insulin and increase of fatty acids). Hydrocortisone 180-188 leptin Homo sapiens 22-28 12718369-6 2003 Prior to and on hydrocortisone treatment in CAH, serum leptin levels were positively correlated with cortisol (r:0.78, p:0.004 and r:0.80, p:0.003) but negatively correlated with testosterone (r:-0.62, p:0.04 and r:-0.65, p:0.002). Hydrocortisone 16-30 leptin Homo sapiens 55-61 12718369-7 2003 These results suggest that serum leptin measurements may be used as an additional parameter in the follow-up of children with CAH to evaluate the efficacy of hydrocortisone treatment with respect to androgenemia. Hydrocortisone 158-172 leptin Homo sapiens 33-39 14601484-38 2002 In obese subjects, leptin levels may be influenced by cortisol levels, high levels of insulin, IGF-1, and beta-endorphin as well as low levels of growth hormone. Hydrocortisone 54-62 leptin Homo sapiens 19-25 11128893-11 2000 Serum cortisol correlated significantly with serum leptin level in the group with SCI. Hydrocortisone 6-14 leptin Homo sapiens 51-57 11824511-3 2001 It was found that leptin effectively and dose-dependently inhibited basal and ACTH-stimulated cortisol and corticosterone secretion in the three types of human adrenocortical adenoma cells. Hydrocortisone 94-102 leptin Homo sapiens 18-24 11824511-6 2001 The inhibition of ACTH-stimulated cortisol and corticosterone secretion by leptin was similar to those found in cells without ACTH stimulation. Hydrocortisone 34-42 leptin Homo sapiens 75-81 11824511-8 2001 These results indicate that leptin is a potent inhibitor of cortisol and corticosterone secretion in human adenomatous adrenocortical cells. Hydrocortisone 60-68 leptin Homo sapiens 28-34 10689640-0 2000 Cord blood leptin levels: relationship to body weight, body mass index, sex and insulin and cortisol levels of maternal-newborn pairs at delivery. Hydrocortisone 92-100 leptin Homo sapiens 11-17 11056138-4 2000 Serum leptin values showed a temporal but significant increase 24 h after the operation and were significantly correlated with the cortisol and progesterone values, which increased temporarily at 12 h. At that time a marked decline in oestradiol concentrations was seen. Hydrocortisone 131-139 leptin Homo sapiens 6-12 11093285-10 2000 Adipocyte leptin mRNA increased by 350% after the hydrocortisone infusion. Hydrocortisone 50-64 leptin Homo sapiens 10-16 11110887-3 2000 Thus, the increased leptin expression observed in obesity could result from the chronic hyperinsulinemia and increased cortisol turnover. Hydrocortisone 119-127 leptin Homo sapiens 20-26 11093285-2 2000 infusion of hydrocortisone or insulin on leptin secretion in humans. Hydrocortisone 12-26 leptin Homo sapiens 41-47 11093285-9 2000 Peak hyperleptinemia occurred after 16h of insulin and 20h of hydrocortisone infusion; peak/baseline plasma leptin levels (ng/ml) were 18.2 +/- 4.2/15.1 +/- 3.3 (placebo, P=0.056), 42.1 +/- 7.0/16.0 +/- 3.8 (hydrocortisone, + 163%, P= 0.008) and 30.2 +/- 4.3/16.6 +/- 2.7 (insulin, +83%, P= 0.024). Hydrocortisone 62-76 leptin Homo sapiens 10-16 10595601-1 1999 The acute response of plasma leptin levels to a hydrocortisone challenge was measured in 16 healthy volunteers. Hydrocortisone 48-62 leptin Homo sapiens 29-35 10522999-7 1999 A strong association was found between plasma leptin and CSF dopamine levels (r = 0.74; P < 0.01) as well as between CSF leptin levels and urinary free cortisol (r = 0.73; P < 0.01). Hydrocortisone 155-163 leptin Homo sapiens 124-130 10487674-0 1999 Levels of leptin during hydrocortisone infusions that mimic normal and reversed diurnal cortisol levels in subjects with adrenal insufficiency. Hydrocortisone 24-38 leptin Homo sapiens 10-16 10487674-0 1999 Levels of leptin during hydrocortisone infusions that mimic normal and reversed diurnal cortisol levels in subjects with adrenal insufficiency. Hydrocortisone 88-96 leptin Homo sapiens 10-16 10487674-2 1999 This pattern of appearance of leptin correlates inversely with the circadian appearance of cortisol. Hydrocortisone 91-99 leptin Homo sapiens 30-36 10599716-10 1999 The plasma leptin increase was paralleled by a rise in insulin level and a decline in glucose and cortisol levels at 6 and 24 h. In conclusion, DKA was associated with decreased plasma leptin concentrations. Hydrocortisone 98-106 leptin Homo sapiens 11-17 9851794-6 1998 Corticotropin (ACTH)-induced adrenal aldosterone, cortisol, and dehydroepiandrosterone secretion was inhibited by leptin in a concentration-dependent manner, whereas this hormone had no significant effect on catecholamine release by primary cultures of human adrenal chromaffin cells. Hydrocortisone 50-58 leptin Homo sapiens 114-120 35480480-5 2022 Using a system theoretic approach, coordinate descent method, and sparse recovery, we deconvolved the serum leptin-cortisol levels. Hydrocortisone 115-123 leptin Homo sapiens 108-114 9755363-0 1998 Dual relation between leptin and cortisol in humans is disturbed in Alzheimer"s disease. Hydrocortisone 33-41 leptin Homo sapiens 22-28 9838240-0 1998 Circadian plasma leptin levels in patients with anorexia nervosa: relation to insulin and cortisol. Hydrocortisone 90-98 leptin Homo sapiens 17-23 9274707-9 1997 Pre-meal and peak insulin levels showed a positive correlation with circulating mean leptin levels (r = +0.65; P < 0.001 and r = +0.78; P < 0.001, respectively) in all subjects, while pre-meal and peak serum cortisol levels showed an inverse relation with leptin levels (r = -0.53; P = 0.002 and r = -0.41; P = 0.02, respectively); this effect was independent of BMI in the obese subjects. Hydrocortisone 214-222 leptin Homo sapiens 85-91 34669746-10 2021 After adjustment for serum insulin and leptin, the correlation between serum cortisol and fasting glucose remained significant. Hydrocortisone 77-85 leptin Homo sapiens 39-45 34359179-9 2021 The ACTH and cortisol levels measured in mares belonged to Group A showed a significant positive correlation with the values of leptin, LDLs, triglycerides and VLDLs, whereas they were negatively correlated with the serum UCP1 and NEFAs values. Hydrocortisone 13-21 leptin Homo sapiens 128-134 9819068-7 1998 RESULTS: Cortisol produced dose-dependent and time-dependent increases in plasma leptin concentrations (time x treatment condition x body mass index; F6,123=10.73; P<.001). Hydrocortisone 9-17 leptin Homo sapiens 81-87 9820079-2 1998 In the elevated leptin level in syndrome 5H (association of hyperinsulinism, hyperglycaemia-NIDDM, hyperlipoproteinaemia with android obesity, arterial hypertension and hirsutism in females with the polycystic ovaries syndrome) participate in a significant way also elevated basal IRI and cortisol levels as well as an elevated postprandial IRI response during oGTT despite the fact that leptin and endothelin-1 levels do not rise significantly during oGTT despite hyperinsulinaemia. Hydrocortisone 289-297 leptin Homo sapiens 16-22 9820079-6 1998 Elevated insulin and cortisol levels maintain elevated leptin levels which in turn enhances the insulin resistance in muscles and at the same time has an impact on the IRI response to postprandial hyperglycaemia. Hydrocortisone 21-29 leptin Homo sapiens 55-61 9435456-11 1998 In healthy controls, plasma leptin and cortisol had reciprocal circadian rhythms with high nocturnal leptin levels and low nocturnal cortisol concentrations; in critically ill patients, this relation was abolished. Hydrocortisone 39-47 leptin Homo sapiens 101-107 35480480-8 2022 Furthermore, the Granger causality test demonstrated a negative prospective predictive relationship between leptin and cortisol, 14 of 18 women. Hydrocortisone 119-127 leptin Homo sapiens 108-114 35480480-9 2022 These results indicate that increases in cortisol are prospectively associated with reductions in leptin and vice versa, suggesting a bidirectional negative inhibitory relationship. Hydrocortisone 41-49 leptin Homo sapiens 98-104 35480480-10 2022 As dysregulation of leptin may result in an abnormality in satiety and thereby associated to obesity, the investigation of leptin-cortisol sparse dynamics may offer a better diagnostic methodology to improve better treatments plans for individuals with obesity. Hydrocortisone 130-138 leptin Homo sapiens 20-26 35480480-10 2022 As dysregulation of leptin may result in an abnormality in satiety and thereby associated to obesity, the investigation of leptin-cortisol sparse dynamics may offer a better diagnostic methodology to improve better treatments plans for individuals with obesity. Hydrocortisone 130-138 leptin Homo sapiens 123-129 33953357-4 2021 RESULTS: We observed a modest correlation between log AUC for salivary cortisol and methylation of leptin in preterm infants and a negative correlation between methylation of region 1 of the glucocorticoid receptor (GR in term-born infants. Hydrocortisone 71-79 leptin Homo sapiens 99-105 27441953-9 2017 Leptin change was not a mediator but an enhancing moderator in the link between stress (high cortisol output and emotional problems) and emotional eating in girls: high reports of emotional eating in 2012 were present in the case of combined high 2-year leptin increase and high stress at baseline. Hydrocortisone 93-101 leptin Homo sapiens 0-6 33491313-7 2021 A 1-SD higher leptin and leptin:adiponectin ratio were associated with a 6.48% and 4.97% lower morning serum cortisol, respectively. Hydrocortisone 109-117 leptin Homo sapiens 14-20 33491313-7 2021 A 1-SD higher leptin and leptin:adiponectin ratio were associated with a 6.48% and 4.97% lower morning serum cortisol, respectively. Hydrocortisone 109-117 leptin Homo sapiens 25-31 33491313-10 2021 CONCLUSIONS: Several measures of adiposity are associated with lower morning serum cortisol among AAs, with leptin having the greatest magnitude. Hydrocortisone 83-91 leptin Homo sapiens 108-114 31347937-9 2020 Higher serum leptin in obese BMI group was associated with a decrease in serum cortisol. Hydrocortisone 79-87 leptin Homo sapiens 13-19 27441953-9 2017 Leptin change was not a mediator but an enhancing moderator in the link between stress (high cortisol output and emotional problems) and emotional eating in girls: high reports of emotional eating in 2012 were present in the case of combined high 2-year leptin increase and high stress at baseline. Hydrocortisone 93-101 leptin Homo sapiens 254-260