PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2525580-2 1989 While there were no significant differences in GH and IGF-I levels between depressed, recovered and control subjects, GH and IGF-I concentrations of cortisol non-suppressors were significantly elevated compared to suppressors. Hydrocortisone 149-157 insulin like growth factor 1 Homo sapiens 125-130 1721565-15 1991 Interventional studies in this patient group with GH and IGF-I must take account of these changes in binding protein and cortisol levels. Hydrocortisone 121-129 insulin like growth factor 1 Homo sapiens 57-62 34082199-10 2021 In the KGN cell line, it was found that cortisol could promote the translocation of the glucocorticoid receptor (GR) into the nucleus and upregulate histone deacetylase 10 (HDAC10) to inhibit the H3K27ac level of IGF1 and its expression and estradiol synthesis. Hydrocortisone 40-48 insulin like growth factor 1 Homo sapiens 213-217 35437976-9 2022 Lower but normal MPC levels were seen in PWS and suggestive of reduced local regeneration of cortisol from cortisone in adipose tissue by the GH-IGF-I system. Hydrocortisone 93-101 insulin like growth factor 1 Homo sapiens 145-150 3654610-10 1987 IGF-I suppressed the GH mRNA induced by cAMP + hydrocortisone as well as suppressing a larger 2.2-kb GH mRNA precursor. Hydrocortisone 47-61 insulin like growth factor 1 Homo sapiens 0-5 3009492-2 1986 Proliferation of these cells was also stimulated by IGF-I and II when added to RPMI 1640 medium, fortified with selenium, hydrocortisone, transferrin, and beta-estradiol. Hydrocortisone 122-136 insulin like growth factor 1 Homo sapiens 52-57 3099250-9 1986 IGF-I levels correlated positively with insulin levels (r = 0.421, p less than 0.001) and negatively with cortisol concentrations (r = -0.400, p less than 0.001). Hydrocortisone 106-114 insulin like growth factor 1 Homo sapiens 0-5 31863690-9 2020 Diversely, lower IGF-I-SDS quartiles were associated with higher blood glucose, insulin, insulin resistance and reduced insulin sensitivity levels with the rise of cortisol quartiles. Hydrocortisone 164-172 insulin like growth factor 1 Homo sapiens 17-22 3711761-9 1986 Inhibition of somatomedin C secretion by cortisol resulted in the inhibition of tumour cell proliferation but stimulation of somatomedin secretion by human GH stimulated the cell proliferation rate. Hydrocortisone 41-49 insulin like growth factor 1 Homo sapiens 14-27 31863690-1 2020 BACKGROUND/OBJECTIVE: Data on metabolic impairments in Cushing"s syndrome and GH deficiency all suggest that the relationship between cortisol and GH/IGF-I axis in obesity may have a role in the related diseases. Hydrocortisone 134-142 insulin like growth factor 1 Homo sapiens 150-155 25836355-7 2015 In remitters change in IGF-I levels during treatment was significantly correlated with change in cortisol levels (p=0.019). Hydrocortisone 97-105 insulin like growth factor 1 Homo sapiens 23-28 31075344-9 2019 In HepG2 cells, cortisol negatively regulated the IGF1 signaling pathway and cholesterol metabolic genes, but this inhibition of the cholesterol metabolic genes could be reversed by glucocorticoid receptor antagonist RU486, whereas exogenous IGF1 treatment only reversed the downregulation of RCT genes by cortisol. Hydrocortisone 16-24 insulin like growth factor 1 Homo sapiens 50-54 31075344-9 2019 In HepG2 cells, cortisol negatively regulated the IGF1 signaling pathway and cholesterol metabolic genes, but this inhibition of the cholesterol metabolic genes could be reversed by glucocorticoid receptor antagonist RU486, whereas exogenous IGF1 treatment only reversed the downregulation of RCT genes by cortisol. Hydrocortisone 16-24 insulin like growth factor 1 Homo sapiens 242-246 30113880-6 2019 The chronic stress model and cortisol-treated HepG2 cells verified that excessive glucocorticoid (GC)-induced GC-IGF1 axis programming enhanced hepatic cholesterol synthesis and output. Hydrocortisone 29-37 insulin like growth factor 1 Homo sapiens 113-117 27710242-8 2016 Furthermore, various associated metabolites were previously mentioned regarding IGF-1-associated diseases, eg, betaine and cortisol in cardiovascular disease and metabolic syndrome, lipid disorders, and diabetes, or have previously been found to associate with differentiation and proliferation or mitochondrial functionality, eg, phospholipids. Hydrocortisone 123-131 insulin like growth factor 1 Homo sapiens 80-85 25874752-3 2015 We aimed to investigate whether the associations between serum IGF-1, glucose, and cortisol levels and perceived age/wrinkle grade occur independently of each other and whether these are mediated via skin wrinkling or via other skin aging features. Hydrocortisone 83-91 insulin like growth factor 1 Homo sapiens 63-68 15879357-6 2005 The subgroup of patients receiving hydrocortisone (HC) replacement (n=24) had significantly lower levels of androgens (suppressed by 80-100%) as well as IGF-I and IGFBP-3 as compared with the patients not receiving HC. Hydrocortisone 35-49 insulin like growth factor 1 Homo sapiens 153-158 23611528-5 2013 IGF-I levels were positively related to IGFBP-3, albumin, triiodothyronine and thyroxine, and inversely related to cortisol, sepsis severity, C-reactive protein, interleukin-6 and age. Hydrocortisone 115-123 insulin like growth factor 1 Homo sapiens 0-5 21803836-4 2011 We examined the regulation of igf1 and igf2 mRNA levels by GH, insulin, and cortisol, and the effects of insulin and cortisol on GH sensitivity in primary cultured hepatocytes of tilapia, a cichlid teleost. Hydrocortisone 76-84 insulin like growth factor 1 Homo sapiens 30-34 20397318-9 2010 Thus, by blocking MuRF1, insulin-like growth factor-1 prevents the breakdown of the thick filament, particularly myosin heavy chain, which is asymmetrically lost in settings of cortisol-linked skeletal muscle atrophy. Hydrocortisone 177-185 insulin like growth factor 1 Homo sapiens 25-53 19492582-0 2009 Hydrocortisone treatment in girls with congenital adrenal hyperplasia inhibits serum dehydroepiandrosterone sulfate and affects the GH-IGF-I system. Hydrocortisone 0-14 insulin like growth factor 1 Homo sapiens 135-140 17371460-1 2007 The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortisone to cortisol. Hydrocortisone 326-334 insulin like growth factor 1 Homo sapiens 52-57 24988876-2 2015 We postulated that birth size is associated with cortisol levels, which itself could alter serum adipomyokines (i.e. adiponectin, IGF-I, myostatin) and glucose metabolism. Hydrocortisone 49-57 insulin like growth factor 1 Homo sapiens 130-135 23611528-6 2013 In multiple regression analysis, IGF-I levels were independently related to IGFBP-3 and albumin (lower in patients with decreased IGFBP-3 and albumin levels) (p<0.001 and p=0.01, respectively), and cortisol (lower in patients with increased cortisol levels) (p=0.04). Hydrocortisone 201-209 insulin like growth factor 1 Homo sapiens 33-38 22269647-8 2012 Although the patient responded to recombinant IGF-I therapy for GHI, we hypothesize that the treatment could have had an inhibitory effect on 11beta-hydroxysteroid dehydrogenase type 1 activity, thereby reducing the availability of cortisol and precipitating adrenal insufficiency. Hydrocortisone 232-240 insulin like growth factor 1 Homo sapiens 46-51 20226630-9 2010 There was a significant positive correlation between magnitude of increase in IGF-1 level and the magnitude of reduction in cortisol level [r=0.52; p=0.002]. Hydrocortisone 124-132 insulin like growth factor 1 Homo sapiens 78-83 20226630-11 2010 Our study findings demonstrate that antipsychotic treatment can result in significant elevation of serum IGF-1 possibly mediated by reduction in cortisol levels. Hydrocortisone 145-153 insulin like growth factor 1 Homo sapiens 105-110 19770497-5 2009 In both groups, fetal IGF-1 levels negatively correlated with fetal cortisol levels. Hydrocortisone 68-76 insulin like growth factor 1 Homo sapiens 22-27 18790068-0 2008 Direct actions of cortisol, thyroxine and growth hormone on IGF-I mRNA expression in sea bream hepatocytes. Hydrocortisone 18-26 insulin like growth factor 1 Homo sapiens 60-65 18790068-7 2008 Our study demonstrated that GH, T(4), and cortisol had direct modulatory effects on IGF-I expression in fish hepatocytes in vitro. Hydrocortisone 42-50 insulin like growth factor 1 Homo sapiens 84-89 15004437-3 2004 This study examined the relative direct contribution of GH/IGF1 in modulating cortisol metabolism. Hydrocortisone 78-86 insulin like growth factor 1 Homo sapiens 59-63 15531488-6 2004 In conclusion, low GH and IGF-I levels, likely enhancing the conversion of cortisone to cortisol, may mask a condition of central hypoadrenalism. Hydrocortisone 88-96 insulin like growth factor 1 Homo sapiens 26-31 15088249-7 2004 1.25 (OH) (2)D3, IGF-1 and the bioavailability IGF-1 index (IGF-1/IGFBP-3) increased by 18.3 % (p = 0.047), 29 % (p = 0.048), 33 % (p = 0.011), respectively, while PTH, testosterone, IGFBP-3 and cortisol concentrations were unchanged. Hydrocortisone 195-203 insulin like growth factor 1 Homo sapiens 47-52 15088249-7 2004 1.25 (OH) (2)D3, IGF-1 and the bioavailability IGF-1 index (IGF-1/IGFBP-3) increased by 18.3 % (p = 0.047), 29 % (p = 0.048), 33 % (p = 0.011), respectively, while PTH, testosterone, IGFBP-3 and cortisol concentrations were unchanged. Hydrocortisone 195-203 insulin like growth factor 1 Homo sapiens 47-52 15004437-11 2004 CONCLUSIONS: Modulation of cortisol metabolism during treatment of active acromegaly is dependent on changes in GH/IGF-1 status and is not influenced by any individual change in body composition or insulin sensitivity. Hydrocortisone 27-35 insulin like growth factor 1 Homo sapiens 115-120 11994370-4 2002 However, treatment with twice or three times daily oral hydrocortisone does not mimic physiological adrenal rhythms and may influence the activity of the GH/IGF-I axis. Hydrocortisone 56-70 insulin like growth factor 1 Homo sapiens 157-162 14671143-9 2003 Serum cortisol levels were higher in girls with AN than in controls (P < 0.0001) and correlated inversely with IGF-I (r = -0.58; P = 0.0001) and weakly with GH concentration (area under the concentration curve; r = -0.43; P = 0.05). Hydrocortisone 6-14 insulin like growth factor 1 Homo sapiens 114-119 12042362-6 2002 Conversely, raising cortisol levels by exogenous infusion earlier in gestation prematurely lowered muscle IGF-I mRNA abundance but had no effect on GHR mRNA. Hydrocortisone 20-28 insulin like growth factor 1 Homo sapiens 106-111 11994370-14 2002 These differences reflect bidirectional interactions between the GH/IGF-I axis and hypothalamic-pituitary-adrenal axis in humans, and are likely to evolve as a result of the exogenous administration of hydrocortisone at fixed doses and at specific time intervals, which leads to a more regular pattern in circulating cortisol concentrations, independent of variations in CRH and ACTH concentrations. Hydrocortisone 202-216 insulin like growth factor 1 Homo sapiens 68-73 11314741-0 2001 Relationships between cortisol, dehydroepiandrosterone sulphate and insulin-like growth factor-I system in dementia. Hydrocortisone 22-30 insulin like growth factor 1 Homo sapiens 68-96 10729024-7 1999 Direct exposure to high cortisol concentrations, however, altered both IGF-I synthesis and action. Hydrocortisone 24-32 insulin like growth factor 1 Homo sapiens 71-76 11786677-16 2001 Finally, the GH/IGF-I modulation of cortisol metabolism may underpin the pathogenesis of common diseases such as central obesity and idiopathic osteoporosis. Hydrocortisone 36-44 insulin like growth factor 1 Homo sapiens 16-21 11786679-8 2001 IGF-I has also been shown to enhance type I collagen formation in hydrocortisone-treated human osteoblasts. Hydrocortisone 66-80 insulin like growth factor 1 Homo sapiens 0-5 11263473-2 2001 In fact, it has been reported that the rhGH (recombinant human GH)-induced IGF-I increase inhibits both cortisol and GH response to MK-0677, a non-peptidyl GH secretagogue in animals. Hydrocortisone 104-112 insulin like growth factor 1 Homo sapiens 75-80 11041314-8 2000 Baseline IGF-1 levels were significantly lower at baseline after chronic hydrocortisone compared with placebo. Hydrocortisone 73-87 insulin like growth factor 1 Homo sapiens 9-14 11041314-11 2000 The TSH and IGF-1 data support the hypothesis that hydrocortisone reduces GH release by enhancing somatostatin and IGF-1 release. Hydrocortisone 51-65 insulin like growth factor 1 Homo sapiens 12-17 11041314-11 2000 The TSH and IGF-1 data support the hypothesis that hydrocortisone reduces GH release by enhancing somatostatin and IGF-1 release. Hydrocortisone 51-65 insulin like growth factor 1 Homo sapiens 115-120 10729024-12 1999 Hence, these results demonstrate that elevated cortisol concentrations can disrupt both IGF-I synthesis and IGF-mediated actions by porcine GC under in vitro conditions, and that specific disruptions are dependent on the stage of follicle maturation. Hydrocortisone 47-55 insulin like growth factor 1 Homo sapiens 88-93 9846170-5 1998 Similarly, IGF-II enhanced ACTH-induced cortisol and DHEA-S secretion more potently than IGF-I. Hydrocortisone 40-48 insulin like growth factor 1 Homo sapiens 11-16 9141522-9 1997 IGF-I (100 ng/mL) had similar effects as IGF-II and significantly (P < 0.001) increased ACTH-, forskolin-, and cAMP-stimulated production of cortisol by 2.8-, 3.9-, and 3.1-fold, respectively, and that of DHEA-S by 1.3-, 1.6-, and 1.4-fold, respectively. Hydrocortisone 144-152 insulin like growth factor 1 Homo sapiens 0-5 9625363-6 1998 In AGA children, cortisol correlated inversely with IGF-I (r=-0.75, P< 0.002) and directly with IGFBP-1 (r=0.52, P <0.05), whereas no correlation between cortisol and IGF system-related variables was observed in IUGR. Hydrocortisone 17-25 insulin like growth factor 1 Homo sapiens 52-57 8923834-3 1996 Treatment for 3 days with IGF-I or -II at nanomolar concentrations or with insulin at micromolar concentrations slightly increased the production of androstenedione, cortisol, and dehydroepiandrosterone about 1.5-fold over that by control cells. Hydrocortisone 166-174 insulin like growth factor 1 Homo sapiens 26-38 9055386-8 1997 These effects of insulin and IGF-I were accompanied by decreases in the ratio of dehydroepiandrosterone/cortisol synthesized from pregnenolone by the cultures. Hydrocortisone 104-112 insulin like growth factor 1 Homo sapiens 29-34 10979048-3 1996 On the other hand, hyperinsulinaemia and disorders in GH, PRL and cortisol release were associated with lower levels of reverse triiodothyronine, gonadotropins, testosterone, 17-corticoids and SHBG and higher levels of triiodothyronine, estradiol, 17-hydroxycorticoids and IGF-I. Hydrocortisone 66-74 insulin like growth factor 1 Homo sapiens 273-278 8923834-6 1996 The secretion of androstenedione was more potently stimulated than that of dehydroepiandrosterone and cortisol, and this effect was more clearly yielded by pretreatment with IGF-II than with IGF-I or insulin. Hydrocortisone 102-110 insulin like growth factor 1 Homo sapiens 174-179 7586625-25 1995 Furthermore, these data suggest that the catabolic hormones (catecholamines, cortisol and glucagon), primarily glucagon seem to be involved in the modulation of IGF-I and IGFBP-1 levels following burn injury. Hydrocortisone 77-85 insulin like growth factor 1 Homo sapiens 161-166 8400589-8 1993 The persistent low levels of IGF-1 reflect the altered nutrition status of the patients, as characterized by the continued negative nitrogen balance and elevated cortisol levels in the early posttrauma period. Hydrocortisone 162-170 insulin like growth factor 1 Homo sapiens 29-34 8691098-0 1996 Cortisol decreases IGF-I mRNA levels in human osteoblast-like cells. Hydrocortisone 0-8 insulin like growth factor 1 Homo sapiens 19-24 8142615-0 1993 Insulin-like growth factor I enhances the formation of type I collagen in hydrocortisone-treated human osteoblasts. Hydrocortisone 74-88 insulin like growth factor 1 Homo sapiens 0-28 8142615-5 1993 Addition of IGF-I to human osteoblasts also treated with hydrocortisone normalized the PICP-formation but did not affect the suppressed osteocalcin-formation. Hydrocortisone 57-71 insulin like growth factor 1 Homo sapiens 12-17 8142615-6 1993 These data indicate that IGF-I reverses selective effects of hydrocortisone on bone. Hydrocortisone 61-75 insulin like growth factor 1 Homo sapiens 25-30