PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7873388-8 1995 We next showed that IL-4 and IFN gamma prevent hydrocortisone-induced programmed cell death and that the rescued malignant B cells mainly express CD23 type A. Hydrocortisone 47-61 interferon gamma Homo sapiens 29-38 9537772-3 1998 OBJECTIVES: Cetirizine and hydrocortisone were compared in their capacity to counteract human keratinocytes activation by IFNgamma. Hydrocortisone 27-41 interferon gamma Homo sapiens 122-130 9537772-7 1998 In contrast, hydrocortisone (10(2) microM) enhanced IFNgamma-induced membrane ICAM-1, reduced expression of HLA-DR and did not alter expression of MHC class I and CD40. Hydrocortisone 13-27 interferon gamma Homo sapiens 52-60 9537772-8 1998 Consistently, high doses of cetirizine decreased, whereas hydrocortisone increased, soluble ICAM-1 levels in the supernatants of IFNgamma-treated keratinocytes. Hydrocortisone 58-72 interferon gamma Homo sapiens 129-137 9164932-6 1997 Our findings support the concept that plasma cortisol and possibly melatonin regulate diurnal variation in the IFN-gamma/IL-10 ratio. Hydrocortisone 45-53 interferon gamma Homo sapiens 111-120 9284972-4 1997 IFN-gamma induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophan-nicotinic acid pathway. Hydrocortisone 105-113 interferon gamma Homo sapiens 0-9 9166857-10 1997 Indeed, IL-10, like IFN-gamma, was able to significantly reduce the amount of B-CLL cell death caused by hydrocortisone-induced apoptosis. Hydrocortisone 105-119 interferon gamma Homo sapiens 20-29 32328292-2 2020 We here found that glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to the active cortisol and thereby regulates tissue glucocorticoid (GC) levels, was greatly upregulated by IFNgamma and TNFalpha in human umbilical cord-derived MSCs (UC-MSCs) in a synergistic manner. Hydrocortisone 154-162 interferon gamma Homo sapiens 247-255 8102154-6 1993 The production of IFN-gamma by IL-12-stimulated neonatal T cells is associated with a small but significant T cell activation evidenced by DNA synthesis and by the expression of the activation markers CD25, CD71, and HLA-DR; moreover, it is inhibited by hydrocortisone, cyclosporin A, and transforming growth factor-beta. Hydrocortisone 254-268 interferon gamma Homo sapiens 18-27 1900217-7 1991 The influence of hydrocortisone on the stimulation of PBMC with PHA resulted in a dose-dependent suppression of IFN gamma production in both test groups, again with significant differences between them. Hydrocortisone 17-31 interferon gamma Homo sapiens 112-121 1900217-8 1991 The IFN gamma concentration was 0.95 ng/ml in the reference group and 0.2 ng/ml in the tumour patients when 0.01 micrograms/ml hydrocortisone was added (P less than 0.05). Hydrocortisone 127-141 interferon gamma Homo sapiens 4-13 1900217-9 1991 At 10 micrograms/ml hydrocortisone suppressed IFN gamma production completely in both groups. Hydrocortisone 20-34 interferon gamma Homo sapiens 46-55 33767693-0 2021 Use of IFNgamma/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock. Hydrocortisone 49-63 interferon gamma Homo sapiens 7-15 33767693-10 2021 We propose IFNgamma/IL10 as a molecular marker supporting the decision to administer hydrocortisone to patients in septic shock. Hydrocortisone 85-99 interferon gamma Homo sapiens 11-19 35199049-6 2022 The current literature bears strong evidence for the benefits of yoga on the levels of circulating cortisol and classical inflammatory markers, such as C-reactive protein (CRP) and cytokines such as interleukin-1 beta (IL-1beta), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma). Hydrocortisone 99-107 interferon gamma Homo sapiens 297-313 35199049-6 2022 The current literature bears strong evidence for the benefits of yoga on the levels of circulating cortisol and classical inflammatory markers, such as C-reactive protein (CRP) and cytokines such as interleukin-1 beta (IL-1beta), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma). Hydrocortisone 99-107 interferon gamma Homo sapiens 315-324 2541203-7 1989 When glucocorticoids were co-incubated with IFN-gamma or LPS, the effect of hydrocortisone and other active steroids was blocked, and the monocytes released high O2-. Hydrocortisone 76-90 interferon gamma Homo sapiens 44-53 3021873-1 1986 Concentrations of hydrocortisone as low as 0.08 microgram/ml significantly reduced the yields of gamma-interferon (IFN-gamma) when phytohemagglutinin (PHA) or concanavalin A (ConA) were used as inducers; however, when staphylococcal enterotoxin A was utilized, higher concentrations (5.0 micrograms/ml) were required to achieve the same effect. Hydrocortisone 18-32 interferon gamma Homo sapiens 115-124 6088631-6 1984 Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not. Hydrocortisone 17-31 interferon gamma Homo sapiens 143-152 35171704-10 2022 In IFN-gamma stimulated condition, pretreatment with HC-5 muM resulted in a significantly increased IL-6 and significantly decreased COX-2 expression compared to the HC untreated control group. Hydrocortisone 53-55 interferon gamma Homo sapiens 3-12 2548970-0 1989 Elevated plasma cortisol levels during interferon-gamma treatment. Hydrocortisone 16-24 interferon gamma Homo sapiens 39-55 2548970-4 1989 Elevated cortisol levels during IFN-gamma treatment may be part of a homeostatic response of the neuroendocrine system to the immunological stimulus induced by IFN-gamma. Hydrocortisone 9-17 interferon gamma Homo sapiens 32-41 2548970-4 1989 Elevated cortisol levels during IFN-gamma treatment may be part of a homeostatic response of the neuroendocrine system to the immunological stimulus induced by IFN-gamma. Hydrocortisone 9-17 interferon gamma Homo sapiens 160-169 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Hydrocortisone 46-60 interferon gamma Homo sapiens 159-168 2499421-6 1989 At 0.1 microgram/ml or higher, dexamethasone, hydrocortisone, methylprednisolone and prednisolone significantly (P less than 0.02) inhibited the production of IFN-gamma: respectively 18.9%, 4.4%, 2.2%, and 12.3% of the IFN-gamma produced by MNC in the absence of steroids. Hydrocortisone 46-60 interferon gamma Homo sapiens 219-228 6435860-5 1984 Hydrocortisone was found to eliminate IFN-gamma production if added within 24 hr after the phytohemagglutinin. Hydrocortisone 0-14 interferon gamma Homo sapiens 38-47 6435860-6 1984 The suppression of IFN-gamma production occurred with hydrocortisone concentrations as low as 0.65 microgram/ml, was associated with a diminished proliferative response to the lectin, and occurred with other interferon inducers including staphylococcal enterotoxin A. Hydrocortisone 54-68 interferon gamma Homo sapiens 19-28 33557291-9 2021 Solely in the open surgery group, cortisol dynamics paralleled changes in interleukin (IL)-1beta, IL-10, IL-1ra, IL-7, IL-8 and tumor necrosis factor (TNF)-alpha but did not correlate with changes in IL-6 or interferon (IFN)-gamma at any time-point. Hydrocortisone 34-42 interferon gamma Homo sapiens 208-230 17587351-6 2007 An inverse correlation was found between the cortisol/DHEA ratio and IFN-gamma levels. Hydrocortisone 45-53 interferon gamma Homo sapiens 69-78 19181373-9 2009 RESULTS: To the extent that children with asthma perceived low support from their parents, children were more resistant to hydrocortisone"s anti-inflammatory effects on IL-5 and IFN-gamma production and had higher circulating levels of eosinophil cationic protein. Hydrocortisone 123-137 interferon gamma Homo sapiens 178-187 19212126-6 2009 Further analysis showed that plasma DHEA levels correlated positively with the in vitroproduction of IFN-gamma by mycobacterial-stimulated PBMCs, and the cortisol/DHEA ratio was inversely correlated with IFN-gamma production. Hydrocortisone 154-162 interferon gamma Homo sapiens 204-213 18381516-11 2008 The ratio of T-cell mitogen-induced interferon-gamma/interleukin-4 secretion was significantly higher in the dexamethasone group than in the hydrocortisone group. Hydrocortisone 141-155 interferon gamma Homo sapiens 36-52 15608502-6 2005 Acitretin as an established antipsoriatic drug and the tyrosine kinase inhibitor imatinib decreased, whereas hydrocortisone as well as dexamethasone increased the IFN-gamma-induced K17 overexpression. Hydrocortisone 109-123 interferon gamma Homo sapiens 163-172 16557037-5 2005 The present study showed that the stress-induced and preovulatory levels of prolactin and estradiol, respectively, increased the production of IFN-gamma and IL-12 levels (and IL-10 in the case of estradiol) in PHA + LPS-stimulated whole blood, and inhibited a hydrocortisone (100 nmol/l) suppressive effect on IFN-gamma, IL-12 and IL-10 productions. Hydrocortisone 260-274 interferon gamma Homo sapiens 143-152 14624357-6 2005 We found that hydrocortisone and dexamethasone enhance IFN-gamma-mediated IDO activity in both human astrocytoma cells and native human astrocytes. Hydrocortisone 14-28 interferon gamma Homo sapiens 55-64 12788307-5 2003 In addition, 15ng/ml of prolactin reversed hydrocortisone suppressive effect on IFN-gamma, IL-12 p70, and IL-10 production in PHA+LPS-stimulated whole blood. Hydrocortisone 43-57 interferon gamma Homo sapiens 80-89 11785930-3 2001 We observed a significant inhibitory effect of hydrocortisone, dexamethasone and the glucocorticoid receptor agonist RU 28362, used at doses of 10(-6) and 10(-5) M, on the production of IFN-gamma and IL-10 by whole blood cells stimulated by mitogens. Hydrocortisone 47-61 interferon gamma Homo sapiens 186-195 11785930-5 2001 A combination of imipramine and dexamethasone or hydrocortisone at doses of 10(-6) or 10(-5) M significantly suppressed the production of IFN-gamma and IL-10, the level of inhibition being similar to that observed for glucocorticoids alone. Hydrocortisone 49-63 interferon gamma Homo sapiens 138-147 10344474-8 1999 Hydrocortisone (10(-4) M) inhibited IL-5 and IFNgamma release. Hydrocortisone 0-14 interferon gamma Homo sapiens 45-53 9877450-4 1998 The current investigation examined the effects of dexamethasone (DEX) mimicking basal, stress, and supraphysiologic levels of cortisol on production of interferon-gamma (IFN-gamma) (type-1), interleukin (IL)-12p40 (type 1), IL-10 (type 2), and IL-4 (type 2) by human PBMC. Hydrocortisone 126-134 interferon gamma Homo sapiens 152-168 9877450-4 1998 The current investigation examined the effects of dexamethasone (DEX) mimicking basal, stress, and supraphysiologic levels of cortisol on production of interferon-gamma (IFN-gamma) (type-1), interleukin (IL)-12p40 (type 1), IL-10 (type 2), and IL-4 (type 2) by human PBMC. Hydrocortisone 126-134 interferon gamma Homo sapiens 170-179