PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23084589-6 2013 The results demonstrated that HHCB and AHTN could inhibit progesterone and cortisol production mainly by the suppression of 3betaHSD2 and CYP21. Hydrocortisone 75-83 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 138-143 26941069-1 2016 CONTEXT: Congenital adrenal hyperplasia (CAH) is caused most often by mutations in the CYP21A2 gene, resulting in cortisol and aldosterone deficiency and increased production of androgens. Hydrocortisone 114-122 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 87-94 26514241-3 2016 The biosynthesis of cortisol involves a cascade of cholesterol metabolizing reactions regulated through three major CYP proteins: 17alpha-hydroxylase-C17/20-lyase (CYP17), 21-hydroxylase (CYP21), and 11beta-hydroxylase (CYP11B1). Hydrocortisone 20-28 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 188-193 26514241-5 2016 A series of novel functionalized dioxane analogs have been developed and recently patented as CYP17, CYP21, and CYP11B1 inhibitors, which lead to the modulation of cortisol production as a method for treating, delaying, slowing, and inhibiting the implicated diseases. Hydrocortisone 164-172 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 101-106 26374204-3 2015 One promising candidate is the mammalian cytochrome P450 CYP21A2 which is involved in steroid hormone biosynthesis and performs a selective oxyfunctionalization of C21 to provide the precursors of aldosterone, the main mineralocorticoid, and cortisol, the most important glucocorticoid. Hydrocortisone 242-250 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 57-64 28893623-12 2017 A loss of CYP21A2 activity in combination with reduction of CYP17A1 activities by abiraterone could result in lower cortisol levels and may require monitoring for any potential adverse effects. Hydrocortisone 116-124 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 10-17 27789139-6 2016 This could be accomplished through inhibition of enzymes in the cortisol synthetic pathway, 11beta-hydroxylase (Cyp11B1), 17alpha-hydroxylase-C17,20-lyase (Cyp17), and 21-hydroxylase (Cyp21). Hydrocortisone 64-72 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 184-189 25210767-4 2014 RESULTS: The carriers (N = 27) of a well-defined CYP21A2 haplotype cluster (c5) had significantly elevated levels of cortisol (p = 0.0110), and 17-hydroxyprogesterone (p = 0.0001) after ACTH stimulation, and 11-deoxycortisol after metyrapone administration (p = 0.0017), but the hormone values were in normal ranges. Hydrocortisone 117-125 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 49-56 24466573-5 2014 TBB did not affect sex-steroid production in this cell model; rather the data suggest a flux towards synthesis of aldosterone and cortisol via up-regulation of CYP21A2. Hydrocortisone 130-138 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 160-167 20423741-1 2010 Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency (21-OHD) is an autosomal recessive disorder caused by the defective CYP21A2 gene that leads to various degrees of impaired secretion of both cortisol and aldosterone. Hydrocortisone 213-221 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 140-147 22886582-1 2012 Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is an autosomal recessive disorder of cortisol biosynthesis caused by CYP21A2 mutations. Hydrocortisone 117-125 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 149-156 21446712-2 2011 CYP21A2 activities, which are required for cortisol and aldosterone biosynthesis, involve the formation of energetically disfavored primary carbon radicals. Hydrocortisone 43-51 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 0-7 21094146-4 2011 We show that normal epidermis and cultured PHK express each of the enzymes (CYP11A1, CYP17A1, 3betaHSD1, CYP21 and CYP11B1) that are required for cortisol synthesis. Hydrocortisone 146-154 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 105-110 15128284-1 2004 The capacity of the adrenal to produce cortisol is controlled in part by 21-hydroxylase (CYP21) and the production of androgens by 17-hydroxylase/17-20-lyase (CYP17), in response to secretagogues including ACTH, angiotensin-II (A-II) and insulin. Hydrocortisone 39-47 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 89-94 17400813-6 2007 Finally, using RT-PCR, we detected expression of genes encoding four key enzymes participating in steroids synthesis (CYP11A1, CYP11B1, CYP17 and CYP21A2) and showed transformation of progesterone into cortisol-immunoreactivity in cultured ARPE-19 cells. Hydrocortisone 202-210 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 146-153 30982438-2 2020 The deficiency of steroid 21-hydroxylase (cytochrome P450 21A2), an enzyme involved in cortisol synthesis, is responsible for ~95% of cases of congenital adrenal hyperplasia. Hydrocortisone 87-95 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 18-40 14513879-1 2003 Steroid 21-hydroxylase deficiency is the major cause of congenital adrenal hyperplasia, an autosomic recessive disorder that affects the synthesis of aldosterone and cortisol. Hydrocortisone 166-174 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 0-22 11250647-1 2001 The management of congenital adrenal hyperplasia due to 21-hydroxylase (CYP21) deficiency requires glucocorticoid substitution with oral hydrocortisone given twice or thrice daily. Hydrocortisone 137-151 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 72-77 7479886-1 1995 Most cases of congenital adrenal hyperplasia, the inherited inability to synthesize cortisol, are caused by mutations in the steroid 21-hydroxylase gene (CYP21). Hydrocortisone 84-92 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 125-147 7479886-1 1995 Most cases of congenital adrenal hyperplasia, the inherited inability to synthesize cortisol, are caused by mutations in the steroid 21-hydroxylase gene (CYP21). Hydrocortisone 84-92 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 154-159 1937474-1 1991 The steroid 21-hydroxylase enzyme (P450c21) is a member of the cytochrome P450 gene superfamily and is essential in the synthesis of cortisol and aldosterone. Hydrocortisone 133-141 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 4-26 2233746-1 1990 Cytochrome P450c21 (steroid 21-hydroxylase) is a key enzyme in the synthesis of cortisol, whose deficiency is the cause of a common genetic disease, congenital adrenal hyperplasia. Hydrocortisone 80-88 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 20-42 9187661-1 1997 Lesions in the gene encoding steroid 21-hydroxylase result in congenital adrenal hyperplasia, with impaired secretion of cortisol and aldosterone from the adrenal cortex and overproduction of androgens. Hydrocortisone 121-129 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 29-51 8989258-1 1997 Lesions in the gene encoding steroid 21-hydroxylase result in congenital adrenal hyperplasia, with impaired secretion of cortisol and aldosterone from the adrenal cortex and overproduction of androgens. Hydrocortisone 121-129 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 29-51 2249999-2 1990 This disorder of cortisol biosynthesis occurs in a wide spectrum of clinical severity; specific mutations in the 21-hydroxylase gene (CYP21) have been found in association with particular clinical phenotypes. Hydrocortisone 17-25 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 134-139 1979956-1 1990 Defects in the enzyme, steroid 21-hydroxylase, result in congenital adrenal hyperplasia (CAH), a common autosomal recessive disorder of cortisol biosynthesis. Hydrocortisone 136-144 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 23-45 32610579-5 2020 Up to 95% cases of CAH are due to mutations in CYP21A2 gene and subsequent 21alpha-hydroxylase deficiency, characterized by impaired cortisol synthesis and adrenal androgen excess. Hydrocortisone 133-141 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 47-54 32203088-3 2020 Pregnenolone is converted to cortisol by the enzymes 3-betaHSD, CYP17A1, CYP21A2, and CYP11B1. Hydrocortisone 29-37 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 73-80