PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2895487-0 1987 Influence of gamma-radiation and cycloheximide on by hydrocortisone induced tyrosine aminotransferase and tryptophan-2,3-dioxygenase activity in the rat liver. Hydrocortisone 53-67 tryptophan 2,3-dioxygenase Rattus norvegicus 106-132 1543500-1 1992 Administration of tryptophan or hydrocortisone to rats caused a several-fold increase in tryptophan-2,3-dioxygenase activity in the liver. Hydrocortisone 32-46 tryptophan 2,3-dioxygenase Rattus norvegicus 89-115 8354392-4 1993 Although an intraperitoneal injection of L-tryptophan increased the activity of skin TDO to approximately 2.2 times greater than control values, an intraperitoneal injection of hydrocortisone and alpha-methyl-DL-tryptophan, both compounds known to affect hepatic TDO activity, had no effect on skin TDO activity. Hydrocortisone 177-191 tryptophan 2,3-dioxygenase Rattus norvegicus 263-266 8354392-4 1993 Although an intraperitoneal injection of L-tryptophan increased the activity of skin TDO to approximately 2.2 times greater than control values, an intraperitoneal injection of hydrocortisone and alpha-methyl-DL-tryptophan, both compounds known to affect hepatic TDO activity, had no effect on skin TDO activity. Hydrocortisone 177-191 tryptophan 2,3-dioxygenase Rattus norvegicus 263-266 6708736-0 1984 Activation of liver tryptophan oxygenase by hydrocortisone, hematin and tryptophan in streptozotocin-diabetic rats. Hydrocortisone 44-58 tryptophan 2,3-dioxygenase Rattus norvegicus 20-40 6708736-1 1984 This study compared changes in liver tryptophan oxygenase (TPO) activity in response to hydrocortisone, hematin and tryptophan administration to non-diabetic and diabetic (streptozotocin) rats. Hydrocortisone 88-102 tryptophan 2,3-dioxygenase Rattus norvegicus 37-57 6708736-1 1984 This study compared changes in liver tryptophan oxygenase (TPO) activity in response to hydrocortisone, hematin and tryptophan administration to non-diabetic and diabetic (streptozotocin) rats. Hydrocortisone 88-102 tryptophan 2,3-dioxygenase Rattus norvegicus 59-62 6708736-2 1984 Hydrocortisone caused similar increases in apoenzyme (inactive), holoenzyme (heme-saturated) and total (holoenzyme + apoenzyme) TPO activities in non-diabetic and diabetic rats. Hydrocortisone 0-14 tryptophan 2,3-dioxygenase Rattus norvegicus 128-131 7296169-0 1981 Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis. Hydrocortisone 103-117 tryptophan 2,3-dioxygenase Rattus norvegicus 79-99 6537939-3 1984 Induction of tryptophan 2,3-dioxygenase activity by L-tryptophan was not altered by the treatment though induction by hydrocortisone was blocked. Hydrocortisone 118-132 tryptophan 2,3-dioxygenase Rattus norvegicus 13-39 7126996-2 1982 2 When liver tryptophan pyrrolase activity is enhanced by pretreatment with cortisol or haematin, subsequent administration of a 0.5 mg/kg dose of some, but not other, antidepressants causes inhibition, which is weak (up to 38%). Hydrocortisone 76-84 tryptophan 2,3-dioxygenase Rattus norvegicus 13-33 7150255-13 1982 Cortisol restores the ability of the porphyrogen to destroy tryptophan pyrrolase haem and to enhance markedly 5-aminolaevulinate synthase activity, presumably by enhancing tryptophan pyrrolase synthesis and, thereby, its re-utilization of the regulatory-haem pool. Hydrocortisone 0-8 tryptophan 2,3-dioxygenase Rattus norvegicus 60-80 7150255-13 1982 Cortisol restores the ability of the porphyrogen to destroy tryptophan pyrrolase haem and to enhance markedly 5-aminolaevulinate synthase activity, presumably by enhancing tryptophan pyrrolase synthesis and, thereby, its re-utilization of the regulatory-haem pool. Hydrocortisone 0-8 tryptophan 2,3-dioxygenase Rattus norvegicus 172-192 182357-4 1976 The enzyme levels and mRNA activities in host livers and hepatomas from control rats and rats given injections of an inducing dose of hydrocortisone were compared; they indicate that the induction of tryptophan oxygenase in host livers by hormones is accompanied by a proportional increase in the level of its mRNA, whereas in the transplanted hepatomas the tryptophan oxygenase catalytic activity and the mRNA coding for this enzyme were undetectable in both control and glucocorticoid-induced animals. Hydrocortisone 134-148 tryptophan 2,3-dioxygenase Rattus norvegicus 200-220 271960-9 1977 We have found that it is also possible to induce tryptophan 2,3-dioxygenase catalytic activity with hydrocortisone precociously in 4-day-old rats. Hydrocortisone 100-114 tryptophan 2,3-dioxygenase Rattus norvegicus 49-75 863931-4 1977 Twenty-one-day-old animals which were adrenalectomized on the 10th day, and thus possess no demonstrable enzymatic activity, could respond to cortisol treatment with an elevation of tryptophan oxygenase activity. Hydrocortisone 142-150 tryptophan 2,3-dioxygenase Rattus norvegicus 182-202 29491-1 1978 The modulation of tryptophan-oxygenase (TO) and tyrosine amino-transferase (TAT) in the rat liver after a single dose of hydrocortisone has been studied under various physiological conditions. Hydrocortisone 121-135 tryptophan 2,3-dioxygenase Rattus norvegicus 18-38 29491-1 1978 The modulation of tryptophan-oxygenase (TO) and tyrosine amino-transferase (TAT) in the rat liver after a single dose of hydrocortisone has been studied under various physiological conditions. Hydrocortisone 121-135 tryptophan 2,3-dioxygenase Rattus norvegicus 40-42 29491-7 1978 3) Higher doses of hydrocortisone were necessary for optimal induction of TO and TAT in normal than in adrenalectomized rats. Hydrocortisone 19-33 tryptophan 2,3-dioxygenase Rattus norvegicus 74-76 29491-8 1978 4) The minimum dose of hydrocortisone necessary for enzyme induction was significantly lower for TO than for TAT. Hydrocortisone 23-37 tryptophan 2,3-dioxygenase Rattus norvegicus 97-99 666843-0 1978 Identification of tryptophan pyrrolase in liver lysosomes after treatment of rats with hydrocortisone and chloroquine. Hydrocortisone 87-101 tryptophan 2,3-dioxygenase Rattus norvegicus 18-38 12944-10 1976 The amount of translatable tyrosine aminotransferase mRNA and tryptophan oxygenase mRNA increases after administration of hydrocortisone to adrenalectomized rats. Hydrocortisone 122-136 tryptophan 2,3-dioxygenase Rattus norvegicus 62-82 182357-4 1976 The enzyme levels and mRNA activities in host livers and hepatomas from control rats and rats given injections of an inducing dose of hydrocortisone were compared; they indicate that the induction of tryptophan oxygenase in host livers by hormones is accompanied by a proportional increase in the level of its mRNA, whereas in the transplanted hepatomas the tryptophan oxygenase catalytic activity and the mRNA coding for this enzyme were undetectable in both control and glucocorticoid-induced animals. Hydrocortisone 134-148 tryptophan 2,3-dioxygenase Rattus norvegicus 358-378 4799079-7 1973 Pretreatment of rats with the above porphyrogens inhibits the rise in holo-(tryptophan pyrrolase) activity produced by subsequent administration of cortisol, tryptophan and 5-aminolaevulinate with two single exceptions, the possible reasons for which are discussed. Hydrocortisone 148-156 tryptophan 2,3-dioxygenase Rattus norvegicus 76-96 4386974-0 1968 Inhibition by aflatonin B-1 of hydrocortisone induction of rat liver tryptophan pyrrolase and tyrosine transaminase. Hydrocortisone 31-45 tryptophan 2,3-dioxygenase Rattus norvegicus 69-89 5296861-0 1966 Induction of tryptophan pyrrolase in rat liver by physiological amounts of hydrocortisone and secreted glucocorticoids. Hydrocortisone 75-89 tryptophan 2,3-dioxygenase Rattus norvegicus 13-33 5667275-2 1968 The effects of various doses of dimethylnitrosamine on the hydrocortisone induction of tryptophan pyrrolase were studied. Hydrocortisone 59-73 tryptophan 2,3-dioxygenase Rattus norvegicus 87-107 5667275-7 1968 A single small dose of dimethylnitrosamine significantly inhibits the hydrocortisone induction of tryptophan pyrrolase for at least 14 days without causing widespread damage to liver substructure. Hydrocortisone 70-84 tryptophan 2,3-dioxygenase Rattus norvegicus 98-118