PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35588458-5 2022 RESULTS: The main results of the correlation analysis revealed that the levels of pro-inflammatory cytokines interleukin (IL)-1beta, IL-12, and tumor necrosis factor gamma were negatively correlated with cortisol scores (area under the curve with respect to the ground). Hydrocortisone 204-212 interleukin 1 alpha Homo sapiens 109-131 2801317-5 1989 Hydrocortisone (IC50:0.084 microM), aurothioglucose (11.5 microM) and lobenzarit (75.0 microM), which are clinically effective antirheumatic drugs, also inhibited IL-1 generation, like E-5110 (1.21 microM). Hydrocortisone 0-14 interleukin 1 alpha Homo sapiens 163-167 35446412-11 2022 Levels of IL-1beta correlate with severity and duration of PTSD and PTSD can be prevented by bolus administration of hydrocortisone in acute sepsis, consistent with unrestrained inflammation being a risk factor for PTSD. Hydrocortisone 117-131 interleukin 1 alpha Homo sapiens 10-18 3502240-2 1987 In addition, Il-1 increased the percentage of thymocytes resistant to hydrocortisone. Hydrocortisone 70-84 interleukin 1 alpha Homo sapiens 13-17 3139548-1 1988 The combined effect of hydrocortisone (HC) and interferon-gamma and -alpha (IFN-gamma and -alpha) on human blood monocytes (Mo) interleukin 1 (IL 1) secretion was investigated. Hydrocortisone 23-37 interleukin 1 alpha Homo sapiens 107-147 3139548-3 1988 Hydrocortisone, at the pharmacological attainable concentration of 10(-5) molar (M), markedly suppressed fresh Mo IL 1 secretion but had no effect at lower tested doses. Hydrocortisone 0-14 interleukin 1 alpha Homo sapiens 114-118 3498758-9 1987 Treatment of human lung fragments in vitro for 18 hr with glucocorticoids such as DEX and hydrocortisone resulted in dose dependent inhibition of IL-1 production; these and other glucocorticoids, at concentrations ranging between 0.1 and 1 microM, produced greater than 50% inhibition of IL-1 release. Hydrocortisone 90-104 interleukin 1 alpha Homo sapiens 146-150 3498758-9 1987 Treatment of human lung fragments in vitro for 18 hr with glucocorticoids such as DEX and hydrocortisone resulted in dose dependent inhibition of IL-1 production; these and other glucocorticoids, at concentrations ranging between 0.1 and 1 microM, produced greater than 50% inhibition of IL-1 release. Hydrocortisone 90-104 interleukin 1 alpha Homo sapiens 288-292 3498758-11 1987 Inhibition of IL-1 production occurred after a lag period 5 of 16 hr, and the relative glucocorticoid potencies agreed with their known anti-inflammatory potencies in vivo (beta-methasone approximately triamcinolone acetonide greater than DEX greater than fludrocortisone greater than prednisolone greater than hydrocortisone). Hydrocortisone 311-325 interleukin 1 alpha Homo sapiens 14-18 33557291-9 2021 Solely in the open surgery group, cortisol dynamics paralleled changes in interleukin (IL)-1beta, IL-10, IL-1ra, IL-7, IL-8 and tumor necrosis factor (TNF)-alpha but did not correlate with changes in IL-6 or interferon (IFN)-gamma at any time-point. Hydrocortisone 34-42 interleukin 1 alpha Homo sapiens 74-96 3491062-10 1986 Low concentrations of hydrocortisone (1 ng/ml) also augmented IL-1 secretion by 58 +/- 20%. Hydrocortisone 22-36 interleukin 1 alpha Homo sapiens 62-66 3491062-11 1986 Higher concentrations in the physiological range had no effect, and combinations of epinephrine and hydrocortisone suppressed IL-1 secretion. Hydrocortisone 100-114 interleukin 1 alpha Homo sapiens 126-130 6809339-0 1982 Modulation of interleukin 1 production by activated macrophages: in vitro action of hydrocortisone, colchicine, and cytochalasin B. Hydrocortisone 84-98 interleukin 1 alpha Homo sapiens 14-27 3488738-3 1986 The bone resorbing activity induced by IL-1 was partially inhibited by indomethacin and hydrocortisone, and completely inhibited by anti-IL 1-antibody. Hydrocortisone 88-102 interleukin 1 alpha Homo sapiens 39-43 6461917-5 1982 The addition of interleukin-1 (IL-1) to HC-A-treated cultures did not restore or increase the synthesis of IL-2, whereas IL-1 added to non HC-A treated cultures significantly enhanced the synthesis of IL-2, Finally, IL-2 but not IL-1 could overcome the abrogatory effect of hydrocortisone on proliferation of T cells induced by AMLR. Hydrocortisone 274-288 interleukin 1 alpha Homo sapiens 121-125 6461917-5 1982 The addition of interleukin-1 (IL-1) to HC-A-treated cultures did not restore or increase the synthesis of IL-2, whereas IL-1 added to non HC-A treated cultures significantly enhanced the synthesis of IL-2, Finally, IL-2 but not IL-1 could overcome the abrogatory effect of hydrocortisone on proliferation of T cells induced by AMLR. Hydrocortisone 274-288 interleukin 1 alpha Homo sapiens 121-125 32375462-1 2020 OBJECTIVE: The association between preterm birth (PTB), Spindle and Kinetochore Associated Complex Subunit 2 gene (SKA2), cortisol and anxiety have been shown, but in this study, we aimed to clarify whether the expression of the SKA2 gene plays a role in interleukin1beta (IL-1beta) level since increasing level of IL-1beta is linked with PTB. Hydrocortisone 122-130 interleukin 1 alpha Homo sapiens 273-281 33295155-5 2021 RESULTS: We propose a speculative hypothesis concerning the complex interplay of these signaling molecules during chronic stress, highlighting the role of IL-1beta as main biomarker of this effects, indeed, during chronic stress its increment transforms this inflammatory signal into a nervous signal (NE), in turn, this uses the ES (melatonin and cortisol) to counterbalance again IL-1beta. Hydrocortisone 348-356 interleukin 1 alpha Homo sapiens 155-163 32638280-10 2021 There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol. Hydrocortisone 310-318 interleukin 1 alpha Homo sapiens 55-63 32375462-1 2020 OBJECTIVE: The association between preterm birth (PTB), Spindle and Kinetochore Associated Complex Subunit 2 gene (SKA2), cortisol and anxiety have been shown, but in this study, we aimed to clarify whether the expression of the SKA2 gene plays a role in interleukin1beta (IL-1beta) level since increasing level of IL-1beta is linked with PTB. Hydrocortisone 122-130 interleukin 1 alpha Homo sapiens 315-323 32076399-5 2019 IL-1beta in turn induces the secretion of corticotropin-releasing hormone (CRH) and in consequence the secretion of adrenocorticotropic hormone (ACTH) and cortisol, which together with a plethora of further cytokines/chemokines lead to mood disorders. Hydrocortisone 155-163 interleukin 1 alpha Homo sapiens 0-8 7531991-4 1994 Similar results were obtained with hydrocortisone, which suppresses IL-1 gene expression. Hydrocortisone 35-49 interleukin 1 alpha Homo sapiens 68-72 33508847-1 2020 INTRODUCTION: IL-1beta, a cytokine from the innate immune response, is well known for its proinflammatory effects and stimulating activity on the hypothalamus-pituitary-adrenal axis, leading to the pituitary synthesis of adrenocorticotropic hormone followed by cortisol (and dehydroepiandrosterone - DHEA) release by the adrenal gland. Hydrocortisone 261-269 interleukin 1 alpha Homo sapiens 14-22 31042669-0 2019 Effects of interleukin-1 antagonism on cortisol levels in individuals with obesity: a randomized clinical trial. Hydrocortisone 39-47 interleukin 1 alpha Homo sapiens 11-24 22934546-14 2012 Finally, there is a strong mechanism data that macrophage produced interleukin 1, tumor necrosis factor and interleukin 6, which are released following inflammation, causing destruction of insulin secreting islet cells and increase cortisol release, and thus have the ability to cause both type 1 and type 2 diabetes/metabolic syndrome (which resembles a Cushingoid state). Hydrocortisone 232-240 interleukin 1 alpha Homo sapiens 67-121 21600230-5 2011 Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P<0.05 for all). Hydrocortisone 38-46 interleukin 1 alpha Homo sapiens 5-14 16015023-4 2005 RESULTS: Intracellular IL-1alpha in TNBS-treated human KCs was increased with a low concentration of 10(-10)M of hydrocortisone. Hydrocortisone 113-127 interleukin 1 alpha Homo sapiens 23-32 15356059-4 2004 Addition of cortisol to OSE cell culture medium dose-dependently suppressed the COX-2 mRNA response to IL1alpha (P < 0.01) but reciprocally enhanced the 11betaHSD1 mRNA response (P < 0.05), with both effects strongest at 1 microm cortisol. Hydrocortisone 12-20 interleukin 1 alpha Homo sapiens 103-111 15356059-6 2004 Glucocorticoid receptor antagonist (RU486, 10 microm) fully reversed the inhibitory effect of 1 microm cortisol on IL1alpha-stimulated COX-2 mRNA expression. Hydrocortisone 103-111 interleukin 1 alpha Homo sapiens 115-123 10749772-2 2000 The purpose of this study was to determine if gender- or age-related differences exist in the sensitivity of IL-1-producing cells to hydrocortisone. Hydrocortisone 133-147 interleukin 1 alpha Homo sapiens 109-113 10749772-5 2000 Hydrocortisone decreased soluble IL-1 receptor type II (sIL-1RII) secretion by unstimulated cells (P = 0. Hydrocortisone 0-14 interleukin 1 alpha Homo sapiens 33-37 8728354-10 1996 HC inhibited the secretion of GM-CSF and LIF induced by IL-1. Hydrocortisone 0-2 interleukin 1 alpha Homo sapiens 56-60 7621583-4 1995 When dexamethasone or hydrocortisone were added to IL-1 alpha, significant potentialization of IL-1 alpha-induced stimulation of C3 and factor B production was observed, occurring at various concentrations of either stimuli. Hydrocortisone 22-36 interleukin 1 alpha Homo sapiens 51-61 7621583-4 1995 When dexamethasone or hydrocortisone were added to IL-1 alpha, significant potentialization of IL-1 alpha-induced stimulation of C3 and factor B production was observed, occurring at various concentrations of either stimuli. Hydrocortisone 22-36 interleukin 1 alpha Homo sapiens 95-105 7621586-8 1995 Hydrocortisone reduced IL-1 alpha to below the limit of sensitivity of the ELISA, and induced a small increase in IL-1Ra of questionable biological significance. Hydrocortisone 0-14 interleukin 1 alpha Homo sapiens 23-33 31880211-6 2019 Serum IL-1beta, IL-6, and TNF-alpha concentrations significantly decreased for hydrocortisone group at day 7 (all p < .01). Hydrocortisone 79-93 interleukin 1 alpha Homo sapiens 6-14 16556968-6 2005 The interpretation of cytokine levels in the blood is complicated by the fact, for example, that the overexpression of IL-1 in Alzheimer brain may act to increase adrenal cortisol production through the hypothalamic-pituitary-adrenal axis, which acts to limit macrophage activation and peripheral cytokine production. Hydrocortisone 171-179 interleukin 1 alpha Homo sapiens 119-123 7786524-8 1995 HC (5 micrograms/ml), 1,25(OH)2D3 (10(-6) M) and MC903 (10(-6) M), but not CsA (5 micrograms/ml), inhibited IL-1 alpha production by HSC-1 cells stimulated with 100 U/ml of rIFN-gamma. Hydrocortisone 0-2 interleukin 1 alpha Homo sapiens 108-118 2007786-6 1991 Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1-induced IL-6 mRNA expression and production by EC. Hydrocortisone 12-26 interleukin 1 alpha Homo sapiens 122-126 8356399-3 1993 We found that hydrocortisone stimulated cell proliferation but inhibited the differentiation of TEC and significantly reduced the production of interleukin-1 alpha, interleukin-6 and granulocyte-macrophage colony stimulating factor. Hydrocortisone 14-28 interleukin 1 alpha Homo sapiens 144-163 8456629-9 1993 As expected, hydrocortisone demonstrated a marked decrease on IL-1 alpha and IL-1 beta, both in the presence and absence of LPS. Hydrocortisone 13-27 interleukin 1 alpha Homo sapiens 62-72 1532379-1 1992 Pretreatment of epidermal cells (EC) with hydrocortisone or dexamethasone abolishes their capacity to produce interleukin-1 (IL-1) and therefore reduces their capacity to support proliferative response of lectin-stimulated T cells. Hydrocortisone 42-56 interleukin 1 alpha Homo sapiens 125-129 1905331-6 1991 Hydrocortisone decreased the expression of both IL-1 alpha and TGF alpha mRNA in keratinocytes. Hydrocortisone 0-14 interleukin 1 alpha Homo sapiens 48-58 1498252-11 1992 In contrast, the addition of the stimulatory agent IL-1 alpha to hydrocortisone-treated cells resulted in no increase in IL-1 beta mRNA. Hydrocortisone 65-79 interleukin 1 alpha Homo sapiens 51-61 2290308-2 1990 Kinetic studies of spontaneous and LPS-induced IL-1 production of isolated monocytes of 10 normal individuals showed a synchronous circadian rhythm, with its maximum at 4:00 p.m. and its minimum at 4:00 a.m., which is most probably independent of the physiological circadian rhythm of cortisol levels because the IL-1 production was of the same value at the times of maximum and minimum cortisol levels. Hydrocortisone 285-293 interleukin 1 alpha Homo sapiens 47-51 1810214-3 1991 In addition, SIRS prevented the IL-1-induced increase in resistance of thymocytes to the lytic action of hydrocortisone. Hydrocortisone 105-119 interleukin 1 alpha Homo sapiens 32-36 2290308-2 1990 Kinetic studies of spontaneous and LPS-induced IL-1 production of isolated monocytes of 10 normal individuals showed a synchronous circadian rhythm, with its maximum at 4:00 p.m. and its minimum at 4:00 a.m., which is most probably independent of the physiological circadian rhythm of cortisol levels because the IL-1 production was of the same value at the times of maximum and minimum cortisol levels. Hydrocortisone 387-395 interleukin 1 alpha Homo sapiens 47-51 2290308-3 1990 In contrast, in a patient with hypercortisolism and a preserved circadian rhythm of cortisol levels, we found the minimum of IL-1 production at 4:00 p.m., 8 hours after the maximum cortisol level was reached. Hydrocortisone 36-44 interleukin 1 alpha Homo sapiens 125-129 2290308-3 1990 In contrast, in a patient with hypercortisolism and a preserved circadian rhythm of cortisol levels, we found the minimum of IL-1 production at 4:00 p.m., 8 hours after the maximum cortisol level was reached. Hydrocortisone 84-92 interleukin 1 alpha Homo sapiens 125-129 2104896-10 1990 Hydrocortisone, at 10 ng/ml, reduced IL-1-induced IL-6 production by more than 50%. Hydrocortisone 0-14 interleukin 1 alpha Homo sapiens 37-41 18722610-9 2009 Because IL-1alpha also generates cortisol formation in OSE by stimulating cortisone reductase activity, these results support a role for intracrine cortisol in minimizing proteolytic damage to the OSE at ovulation. Hydrocortisone 33-41 interleukin 1 alpha Homo sapiens 8-17 34876829-12 2021 Moreover, using multivariate regression analysis, we showed that ONOO- and IL-1beta depended on cortisol level, while ONOO-, nitrotyrosine and HIF-1alpha were associated with aldosterone. Hydrocortisone 96-104 interleukin 1 alpha Homo sapiens 75-83