PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12788054-7 2003 Hydrocortisone at a dose, which inhibits cell death also down regulated, the expression of pro-inflammatory cytokines IL-6 and IL-8. Hydrocortisone 0-14 interleukin 6 Homo sapiens 118-122 12429044-7 2002 The increase of cortisol relative to DHEA appears 4 h after endotoxin injection and 2 h after a strong increase of interleukin (IL)-6 relative to tumour necrosis factor (TNF). Hydrocortisone 16-24 interleukin 6 Homo sapiens 115-133 12429044-9 2002 The ratio of serum IL-6/TNF was positively correlated with the ratio of serum cortisol/DHEA (R(Rank)=0.472, P=0.041) and serum cortisol/17OH-progesterone (R(Rank)=0.514, P=0.048). Hydrocortisone 78-86 interleukin 6 Homo sapiens 19-23 12429044-9 2002 The ratio of serum IL-6/TNF was positively correlated with the ratio of serum cortisol/DHEA (R(Rank)=0.472, P=0.041) and serum cortisol/17OH-progesterone (R(Rank)=0.514, P=0.048). Hydrocortisone 127-135 interleukin 6 Homo sapiens 19-23 9832618-3 1998 Both synthetic and natural glucocorticoids, i.e., dexamethasone (DEX) and hydrocortisone (HC), respectively, concentration-dependently inhibited protein production and gene expression of IL-6 by human FLSs. Hydrocortisone 74-88 interleukin 6 Homo sapiens 187-191 12357144-8 2002 The early cortisol responses were negatively correlated with the concomitant interleukin-6 serum concentrations (r(2) = 0.298; = 0.003). Hydrocortisone 10-18 interleukin 6 Homo sapiens 77-90 11251036-6 2001 The infusion of hydrocortisone was associated with significant reductions in serum IL-6 and IL-8 levels and with earlier resolution of the sepsis-induced organ dysfunction syndrome. Hydrocortisone 16-30 interleukin 6 Homo sapiens 83-87 10880268-9 2000 There were slightly higher TNF-alpha and IL-6 levels after the operation and significantly lower cortisol levels during the operation in the regional anaesthesia group compared to the general anaesthesia group, giving rise to a significant inverse correlation between peak values of IL-6 and peak values of cortisol. Hydrocortisone 97-105 interleukin 6 Homo sapiens 283-287 10880268-9 2000 There were slightly higher TNF-alpha and IL-6 levels after the operation and significantly lower cortisol levels during the operation in the regional anaesthesia group compared to the general anaesthesia group, giving rise to a significant inverse correlation between peak values of IL-6 and peak values of cortisol. Hydrocortisone 307-315 interleukin 6 Homo sapiens 283-287 10888707-4 2000 In PMR patients, serum levels of IL-6 were positively correlated with serum levels of ASD (P < 0.001), cortisol (P < 0.001), and DHEAS (P = 0. Hydrocortisone 106-114 interleukin 6 Homo sapiens 33-37 10711865-6 2000 Hydrocortisone (0.05 micromol/L to 50 micromol/L) inhibited cytokine release in a dose-dependent manner with ED50 values of 0.23 micromol/L, 0.19 micromol/L, and 0.10 micromol/L for IL-6, IL-8, and TNF-alpha, respectively. Hydrocortisone 0-14 interleukin 6 Homo sapiens 182-186 10844583-5 2000 Postoperatively, on the day of surgery, ACTH and cortisol concentrations in group 1 patients were positively correlated to the blood concentrations of IL-1beta, IL-6 and TNF-alpha. Hydrocortisone 49-57 interleukin 6 Homo sapiens 161-165 10844583-8 2000 In the early postoperative period, cytokines appear to be involved in the activation of the HPA axis, while in the later postoperative period, high cortisol concentrations may inhibit the release of IL-6. Hydrocortisone 148-156 interleukin 6 Homo sapiens 199-203 10692080-7 2000 RESULTS: A significant correlation was present between IL-6 and cortisol levels the first two days after stroke (P < 0.05). Hydrocortisone 64-72 interleukin 6 Homo sapiens 55-59 8805670-7 1996 IL-13 pretreatment of monocytes significantly diminished (p = 0.005) the suppressive effects of hydrocortisone on LPS-induced IL-6 production. Hydrocortisone 96-110 interleukin 6 Homo sapiens 126-130 9246192-7 1997 As the IL-6 promoter contains multiple binding sites for activated glucocorticoid receptors within the 5" regulatory region, the potential modulation of IL-6 expression by the corticosteroids hydrocortisone, dexamethasone and mometasone furoate was included in our study to modify the radiation-induced stress response. Hydrocortisone 192-206 interleukin 6 Homo sapiens 7-11 9246192-7 1997 As the IL-6 promoter contains multiple binding sites for activated glucocorticoid receptors within the 5" regulatory region, the potential modulation of IL-6 expression by the corticosteroids hydrocortisone, dexamethasone and mometasone furoate was included in our study to modify the radiation-induced stress response. Hydrocortisone 192-206 interleukin 6 Homo sapiens 153-157 9062617-0 1997 The effect of cortisol suppression on interleukin-6 and white blood cell responses to surgery. Hydrocortisone 14-22 interleukin 6 Homo sapiens 38-51 9749865-6 1998 Hydrocortisone significantly suppressed the production of IL-6, IL-8, and GM-CSF by TCCs from AH of VKH patients. Hydrocortisone 0-14 interleukin 6 Homo sapiens 58-62 9496240-0 1998 Effects of cortisol on the expression of interleukin-6 and interleukin-1 beta in human osteoblast-like cells. Hydrocortisone 11-19 interleukin 6 Homo sapiens 41-54 8050200-1 1994 The effect of hydrocortisone (HC) on IL-6 production by monocytes (Mo) that were cultured under either adherent or limited-adherent culture conditions was determined. Hydrocortisone 14-28 interleukin 6 Homo sapiens 37-41 8843757-4 1996 There was no difference in either the epinephrine or norepinephrine peaks among the three treatments, but the net area under the curve for IL-6 was smaller after hydrocortisone or dexamethasone than after placebo and smaller after dexamethasone than after hydrocortisone. Hydrocortisone 162-176 interleukin 6 Homo sapiens 139-143 8843757-4 1996 There was no difference in either the epinephrine or norepinephrine peaks among the three treatments, but the net area under the curve for IL-6 was smaller after hydrocortisone or dexamethasone than after placebo and smaller after dexamethasone than after hydrocortisone. Hydrocortisone 256-270 interleukin 6 Homo sapiens 139-143 7638758-2 1995 In that study, subjects with vastly exaggerated levels of tumor necrosis factor (TNF) and interleukin (IL)-6 12 and 144 hours after cortisol infusion exhibited hemodynamic and hormonal responses no different from those of untreated subjects after endotoxin. Hydrocortisone 132-140 interleukin 6 Homo sapiens 90-108 7527666-9 1994 (2) Hydrocortisone counteracted the stimulatory effect of recombinant human cytokines (interleukin-3, interleukin-6, and steel factor) in assays performed on MS-5 but not on human marrow feeders. Hydrocortisone 4-18 interleukin 6 Homo sapiens 102-115 8964868-11 1996 The increased IL-6 production that occurs when cortisol levels fall might explain the symptomatology of acute glucocorticoid deficiency. Hydrocortisone 47-55 interleukin 6 Homo sapiens 14-18 8822343-7 1996 Treatment with hydrocortisone (1 microM), a known inhibitor of IL-6 production in many cell types, reduced IL-6 production to 17 +/- 1% of control (p < 0.001). Hydrocortisone 15-29 interleukin 6 Homo sapiens 63-67 8822343-7 1996 Treatment with hydrocortisone (1 microM), a known inhibitor of IL-6 production in many cell types, reduced IL-6 production to 17 +/- 1% of control (p < 0.001). Hydrocortisone 15-29 interleukin 6 Homo sapiens 107-111 7516173-6 1994 A greater than 95% decrease in IL-6 production was seen with 10(-6) and 10(-7) M dexamethasone, prednisolone, and hydrocortisone, and IC50 values for these agents were approximately 5 x 10(-10), 5 x 10(-9), and 10(-8) M, respectively. Hydrocortisone 114-128 interleukin 6 Homo sapiens 31-35 8050200-1 1994 The effect of hydrocortisone (HC) on IL-6 production by monocytes (Mo) that were cultured under either adherent or limited-adherent culture conditions was determined. Hydrocortisone 30-32 interleukin 6 Homo sapiens 37-41 8356399-3 1993 We found that hydrocortisone stimulated cell proliferation but inhibited the differentiation of TEC and significantly reduced the production of interleukin-1 alpha, interleukin-6 and granulocyte-macrophage colony stimulating factor. Hydrocortisone 14-28 interleukin 6 Homo sapiens 165-178 8403558-0 1993 Hydrocortisone regulation of interleukin-6 protein production by a purified population of human peripheral blood monocytes. Hydrocortisone 0-14 interleukin 6 Homo sapiens 29-42 8403558-1 1993 The direct effect of the endogenous glucocorticoid (GC) hydrocortisone (HC) on interleukin-6 (IL-6) production was examined using purified populations of human peripheral blood monocytes (Mo). Hydrocortisone 56-70 interleukin 6 Homo sapiens 79-92 8403558-1 1993 The direct effect of the endogenous glucocorticoid (GC) hydrocortisone (HC) on interleukin-6 (IL-6) production was examined using purified populations of human peripheral blood monocytes (Mo). Hydrocortisone 56-70 interleukin 6 Homo sapiens 94-98 1431212-0 1992 Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol. Hydrocortisone 102-116 interleukin 6 Homo sapiens 73-86 8391424-10 1993 In view of the role of IL-6 in the inflammatory process and other acute phase phenomena, these data suggest that its effects on CBG synthesis might influence the bioavailability of cortisol indirectly and play a role in regulating the homeostatic process during these conditions. Hydrocortisone 181-189 interleukin 6 Homo sapiens 23-27 1431212-6 1992 Both hydrocortisone and dexamethasone dose-dependently inhibited the cytokine-induced IL-6 production, whereas the inhibition by calcitriol was less pronounced. Hydrocortisone 5-19 interleukin 6 Homo sapiens 86-90 1536986-9 1992 rhIL-1 alpha (10 U/ml) was a consistent and potent stimulator of IL-6 and TNF release, and the glucocorticoid hydrocortisone was found to be a powerful suppressor of both IL-6 and TNF release under basal or stimulatory conditions. Hydrocortisone 110-124 interleukin 6 Homo sapiens 171-175 8434535-3 1993 Hydrocortisone reduced the production of the LPS-stimulated IL-6 to a half level. Hydrocortisone 0-14 interleukin 6 Homo sapiens 60-64 2031150-5 1991 Cortisol and dexamethasone, but not oestrogen, progesterone, or testosterone, dramatically suppressed the LPS-stimulated secretion of IL-6 by fetal Kupffer cells. Hydrocortisone 0-8 interleukin 6 Homo sapiens 134-138 2007786-6 1991 Addition of hydrocortisone, prednisolone, or dexamethasone immediately after UVB irradiation significantly blocked UVB or IL-1-induced IL-6 mRNA expression and production by EC. Hydrocortisone 12-26 interleukin 6 Homo sapiens 135-139 18475434-0 1992 Effect of hydrocortisone on interleukin-6 production in human ,peripheral blood rnononuclear ceils. Hydrocortisone 10-24 interleukin 6 Homo sapiens 28-41 18475434-1 1992 The effect of hydrocortisone on the production of interleukin-6 (IL-6) in human peripheral blood mononuclear cells was studied. Hydrocortisone 14-28 interleukin 6 Homo sapiens 50-63 18475434-1 1992 The effect of hydrocortisone on the production of interleukin-6 (IL-6) in human peripheral blood mononuclear cells was studied. Hydrocortisone 14-28 interleukin 6 Homo sapiens 65-69 18475434-5 1992 Hydrocortisone (10(-10) M to 10(-3) M) inhibited LPS-stimulated IL-6 production in a dose-dependent manner. Hydrocortisone 0-14 interleukin 6 Homo sapiens 64-68 34757578-9 2022 Meanwhile, the most effective corticosteroid, interleukin-6 antagonist, and Janus kinase (JAK) inhibitor were hydrocortisone, sarilumab, and ruxolitinib, respectively. Hydrocortisone 110-124 interleukin 6 Homo sapiens 46-59 2104896-10 1990 Hydrocortisone, at 10 ng/ml, reduced IL-1-induced IL-6 production by more than 50%. Hydrocortisone 0-14 interleukin 6 Homo sapiens 50-54 34342052-7 2021 Correlations were observed between the neutrophil count and G-CSF, IL-6, and cortisol (G-CSF; r = 0.667, IL-6; r = 0.667, cortisol; r = 0.623). Hydrocortisone 77-85 interleukin 6 Homo sapiens 105-109 34342052-8 2021 CONCLUSION: These results suggest that G-CSF is directly involved, and IL-6 is involved via cortisol in the transient neutrophilia that occurs after marathon races. Hydrocortisone 92-100 interleukin 6 Homo sapiens 71-75 34342052-5 2021 Time-course studies with complete blood counts, biochemical markers, cytokines, and cortisol showed transient increases in neutrophils, monocytes, myoglobin, high-sensitivity C-reactive protein (hsCRP), G-CSF, IL-6, and cortisol. Hydrocortisone 84-92 interleukin 6 Homo sapiens 210-214 34506568-10 2021 Correlation analysis showed that levels of LPS from severe patients were positively associated with IL-6 and IFN-gamma plasma concentrations and with IL-1beta transcripts, while IL-6 had a positive correlation with the cortisol/DHEA ratio. Hydrocortisone 219-227 interleukin 6 Homo sapiens 178-182 34563836-9 2021 Furthermore, cortisol interacted with HSV-1 and IL-6, and CRP for both cross-sectional cognitive function and rate of decline. Hydrocortisone 13-21 interleukin 6 Homo sapiens 48-52 35199049-6 2022 The current literature bears strong evidence for the benefits of yoga on the levels of circulating cortisol and classical inflammatory markers, such as C-reactive protein (CRP) and cytokines such as interleukin-1 beta (IL-1beta), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma). Hydrocortisone 99-107 interleukin 6 Homo sapiens 245-249 34440184-6 2021 In intermittent treatment, cortisol acted mainly as an anti-inflammatory hormone, repressing gene expression of kinin B1 receptors, interleukin-6, and interleukin-1beta. Hydrocortisone 27-35 interleukin 6 Homo sapiens 132-145 35226999-7 2022 Higher cortisol levels during pregnancy were associated with elevated IL-6 concentrations. Hydrocortisone 7-15 interleukin 6 Homo sapiens 70-74 34486582-7 2021 CONCLUSIONS: Keratoconus eyes that are progressing have a higher concentration of IL-6 and long-term cortisol than patients with stable forms of KC;Second, there is a significant correlation between this increase in IL6 and cortisol with corneal structural damage.Finally, there is a meaningful relationship between this interleukin and the past few months" cortisol levels. Hydrocortisone 101-109 interleukin 6 Homo sapiens 216-219 35171704-10 2022 In IFN-gamma stimulated condition, pretreatment with HC-5 muM resulted in a significantly increased IL-6 and significantly decreased COX-2 expression compared to the HC untreated control group. Hydrocortisone 53-55 interleukin 6 Homo sapiens 100-104 33557291-9 2021 Solely in the open surgery group, cortisol dynamics paralleled changes in interleukin (IL)-1beta, IL-10, IL-1ra, IL-7, IL-8 and tumor necrosis factor (TNF)-alpha but did not correlate with changes in IL-6 or interferon (IFN)-gamma at any time-point. Hydrocortisone 34-42 interleukin 6 Homo sapiens 200-204 32648790-3 2020 AIMS: We are evaluating the blood inflammatory biomarkers: C-reactive protein and interleukin 6, as a potential consequence of ayahuasca intake and their correlation with serum cortisol and brain-derived neurotrophic factor levels. Hydrocortisone 177-185 interleukin 6 Homo sapiens 82-95 33536381-2 2021 Cytokines, including tumor necrosis factor-alpha and interleukin-6 induce hypercortisolemia by enhancing the ACTH-independent synthesis and secretion of cortisol and by reducing cortisol breakdown. Hydrocortisone 79-87 interleukin 6 Homo sapiens 53-66 33536381-2 2021 Cytokines, including tumor necrosis factor-alpha and interleukin-6 induce hypercortisolemia by enhancing the ACTH-independent synthesis and secretion of cortisol and by reducing cortisol breakdown. Hydrocortisone 153-161 interleukin 6 Homo sapiens 53-66 33227660-5 2020 IL-6 maximal increase correlated with the maximal increase of serum cortisol (rs = 0.48; P = 0.013), salivary cortisol (rs = 0.66; P = 0.012), plasma ACTH (rs = 0.48; P = 0.013) and with the increase in procedure-related symptoms of anxiety and hypoglycemia (rs = 0.57; P = 0.003). Hydrocortisone 68-76 interleukin 6 Homo sapiens 0-4 33227660-5 2020 IL-6 maximal increase correlated with the maximal increase of serum cortisol (rs = 0.48; P = 0.013), salivary cortisol (rs = 0.66; P = 0.012), plasma ACTH (rs = 0.48; P = 0.013) and with the increase in procedure-related symptoms of anxiety and hypoglycemia (rs = 0.57; P = 0.003). Hydrocortisone 110-118 interleukin 6 Homo sapiens 0-4 31102070-0 2019 Adrenal insufficiency treated with conventional hydrocortisone leads to elevated levels of Interleukin-6: a pilot study. Hydrocortisone 48-62 interleukin 6 Homo sapiens 91-104 31880211-6 2019 Serum IL-1beta, IL-6, and TNF-alpha concentrations significantly decreased for hydrocortisone group at day 7 (all p < .01). Hydrocortisone 79-93 interleukin 6 Homo sapiens 16-20 31543817-9 2019 The glucocorticoid hydrocortisone caused substantial inhibition of the endotoxin-induced release of IL-26, IL-6, and IL-8, an effect paralleled by a decrease of the phosphorylation of NF-kappaB, p38, and ERK1/2. Hydrocortisone 19-33 interleukin 6 Homo sapiens 107-111 31902257-6 2020 The induction of 11beta-HSD1 by IL-1beta was further inducted by cortisol, whereas the induction of IL-1beta and IL-6 expression by IL-1beta was completely inhibited by cortisol. Hydrocortisone 169-177 interleukin 6 Homo sapiens 113-117 32046214-5 2020 Statistically significant higher plasma levels of IL-6, while lower TNFalpha, were detected in workers with cortisol >10 ng/mL. Hydrocortisone 108-116 interleukin 6 Homo sapiens 50-54 27930715-12 2016 Basal cortisol level was positively correlated with serum IL-6 level in all patients before glucocorticoid therapy. Hydrocortisone 6-14 interleukin 6 Homo sapiens 58-62 28918107-8 2018 Depression was directly related to evening salivary cortisol and inflammation, such that higher evening cortisol predicted greater depressive symptoms (beta=0.215, p<0.01) and higher pro-inflammatory cytokines (interleukin-2 [IL-2], IL-6, and tumor necrosis factor-alpha [TNF-alpha] levels (beta=0.185, p<0.05), when controlling for covariates. Hydrocortisone 104-112 interleukin 6 Homo sapiens 236-240 28262601-0 2017 IL-6 and TNF-alpha in unmedicated adults with ADHD: Relationship to cortisol awakening response. Hydrocortisone 68-76 interleukin 6 Homo sapiens 0-4 28262601-10 2017 Negative associations between IL-6 (r=-0.386, p=0.020), TNF-alpha (r=-0.372, p=0.023) and cortisol awakening response were found in the inattentive subtype, whereas no association was seen in the combined subtype. Hydrocortisone 90-98 interleukin 6 Homo sapiens 30-34 31019814-6 2019 To our knowledge, this is the first case report of IL6-producing pheochromocytoma along with autonomous cortisol production. Hydrocortisone 104-112 interleukin 6 Homo sapiens 51-54 28810889-10 2017 Cirrhotic patients with lower DHEAS/cortisol ratio (<1.50) had higher levels of interleukin-6 and tumor necrosis factor alpha, higher Sequential Organ Failure Assessment scores, and higher rates of CIRCI and hospital mortality. Hydrocortisone 36-44 interleukin 6 Homo sapiens 83-128 27056727-9 2016 Hydrocortisone significantly attenuated IL-1beta-induced inflammatory responses in the immature human gut when administered at the time of the proinflammatory insult: IL-1beta-induced IL-8 and IL-6 secretion in the fetal ileum as well as H4 cells were significantly reduced. Hydrocortisone 0-14 interleukin 6 Homo sapiens 193-197 21187140-10 2011 Pharmacological concentrations of cortisol (1000 nM) inhibited IL-6 production by SCC9 and SCC25 cells. Hydrocortisone 34-42 interleukin 6 Homo sapiens 63-67 25038103-7 2014 The resting levels of IL-6, IL-10, and TNF-alpha after the exercise training in SLE reached HC levels (P > 0.05). Hydrocortisone 92-94 interleukin 6 Homo sapiens 22-26 23097096-3 2012 We had found a significant decrease in IL-6 in patients having bilateral total knee replacement who received two doses of 100 mg of hydrocortisone eight hours apart; however, by twenty-four hours, IL-6 levels were equal to those in the group that received a placebo. Hydrocortisone 132-146 interleukin 6 Homo sapiens 39-43 23097096-14 2012 CONCLUSIONS: Hydrocortisone (100 mg) given over three doses, each eight hours apart, decreased and maintained a lower degree of inflammation with bilateral total knee replacement as measured by IL-6 level. Hydrocortisone 13-27 interleukin 6 Homo sapiens 194-198 23019942-13 2012 The serum cortisol level was negatively correlated with serum TNF-alpha (r = -0.26, P = 0.03) and serum IL-6 (r = -0.25, P = 0.03). Hydrocortisone 10-18 interleukin 6 Homo sapiens 104-108 23019942-14 2012 The salivary cortisol level was negatively correlated with IL-6 in the induced sputum (r = -0.29, P = 0.02). Hydrocortisone 13-21 interleukin 6 Homo sapiens 59-63 21770806-7 2011 The concentration of IL-6, 8 was also enhanced by low-concentration hydrocortisone and inhibited by high-concentration hydrocortisone. Hydrocortisone 68-82 interleukin 6 Homo sapiens 21-25 21770806-7 2011 The concentration of IL-6, 8 was also enhanced by low-concentration hydrocortisone and inhibited by high-concentration hydrocortisone. Hydrocortisone 119-133 interleukin 6 Homo sapiens 21-25 26431803-6 2016 In controls, the rise in cortisol following the challenge was negatively correlated to the subsequent changes in IL-6 (r=-.461, p=.003), such that rise of cortisol immediately after stress predicts subsequently lower IL-6 levels. Hydrocortisone 25-33 interleukin 6 Homo sapiens 113-117 25513788-13 2015 Plasma-free cortisol, plasma total cortisol, and plasma-free cortisol/plasma total cortisol were positively correlated with interleukin-6 (p = 0.0001, p < 0.0004, and p < 0.001, respectively) and day 90 mortality (p = 0.03, p = 0.03, and p = 0.058, respectively). Hydrocortisone 12-20 interleukin 6 Homo sapiens 124-137 21187140-11 2011 Cortisol dose that simulates stress conditions (10 nM) tended to increase IL-6 expression in SCC9 cells. Hydrocortisone 0-8 interleukin 6 Homo sapiens 74-78 19956406-6 2009 RESULTS: Incubation of HCFs with hydrocortisone markedly inhibited the expression of TLR2 and TLR4 mRNAs and decreased the release of IL-6 and IL-8 in a dose-dependent manner. Hydrocortisone 33-47 interleukin 6 Homo sapiens 134-138 21455087-13 2011 CONCLUSIONS: The use of hydrocortisone significantly decreased the inflammatory response in patients undergoing BTKR as measured by IL-6 production. Hydrocortisone 24-38 interleukin 6 Homo sapiens 132-136 21441882-9 2011 Furthermore, patients from the hydrocortisone group had significantly lower levels of IL-6 (275 [162/677] pg/mL vs. 450 [320/660] pg/mL, P=0.001) and a shorter stay in the ICU (1 [1/3] day vs. 2 [2/3] days, P=0.04). Hydrocortisone 31-45 interleukin 6 Homo sapiens 86-90 20951370-8 2010 Hydrocortisone administration significantly reduced IL-6 levels in both PTSD groups; however, IL-6 levels in PTSD + MDD were higher than both PTSD - MDD (p < .05) and healthy control subjects (p < .01). Hydrocortisone 0-14 interleukin 6 Homo sapiens 52-56 20951370-8 2010 Hydrocortisone administration significantly reduced IL-6 levels in both PTSD groups; however, IL-6 levels in PTSD + MDD were higher than both PTSD - MDD (p < .05) and healthy control subjects (p < .01). Hydrocortisone 0-14 interleukin 6 Homo sapiens 94-98 21428190-14 2010 There was a negative correlation between cortisol level at 08:00 am and IL-6 (r = -0.45). Hydrocortisone 41-49 interleukin 6 Homo sapiens 72-76 19956406-8 2009 The result of ELISA also showed the release of IL-6 and IL-8 can also be inhibited by hydrocortisone. Hydrocortisone 86-100 interleukin 6 Homo sapiens 47-51 19325469-11 2009 The patients from the hydrocortisone group (n = 19) had significantly lower levels of IL-6 and higher levels of IL-10, resulting in an attenuated change in IL-6/IL-10 ratio (28.7 [6.4/128.7] vs. 292.8 [6.5/534.6] 4 hours after cardiopulmonary bypass; p < 0.001). Hydrocortisone 22-36 interleukin 6 Homo sapiens 156-160 19839871-8 2009 The result of ELISA also showed the release of IL-6 and IL-8 can be inhibited by hydrocortisone. Hydrocortisone 81-95 interleukin 6 Homo sapiens 47-51 19325469-0 2009 Stress doses of hydrocortisone in high-risk patients undergoing cardiac surgery: effects on interleukin-6 to interleukin-10 ratio and early outcome. Hydrocortisone 16-30 interleukin 6 Homo sapiens 92-105 19325469-4 2009 OBJECTIVE: To evaluate immunologic effects (especially IL-6 to IL-10 ratio) of stress doses of hydrocortisone in a high-risk group of patients after cardiac surgery with cardiopulmonary bypass. Hydrocortisone 95-109 interleukin 6 Homo sapiens 55-59 19325469-11 2009 The patients from the hydrocortisone group (n = 19) had significantly lower levels of IL-6 and higher levels of IL-10, resulting in an attenuated change in IL-6/IL-10 ratio (28.7 [6.4/128.7] vs. 292.8 [6.5/534.6] 4 hours after cardiopulmonary bypass; p < 0.001). Hydrocortisone 22-36 interleukin 6 Homo sapiens 86-90 19325469-13 2009 CONCLUSIONS: Stress doses of hydrocortisone attenuate the evolution of IL-6/IL-10 ratio in patients with systemic inflammatory response syndrome after CS, which seems to be associated with an improved outcome. Hydrocortisone 29-43 interleukin 6 Homo sapiens 71-75 19325469-14 2009 The immunologic effects of hydrocortisone may thus be both, inhibitory (IL-6) and permissive (IL-10), regarding the immune response. Hydrocortisone 27-41 interleukin 6 Homo sapiens 72-76 18824040-7 2009 Cortisol treatment reduced retrieval of neutral and emotional words (marginally significant at p=0.07), and significantly reduced stimulated IL-6 production (p<0.001). Hydrocortisone 0-8 interleukin 6 Homo sapiens 141-145 18368033-5 2008 The results show that glucocorticoids (dexamethasone, prednisolone, cortisol and corticosterone) caused a concentration-dependent inhibition of LPS-stimulated IL-6 levels. Hydrocortisone 68-76 interleukin 6 Homo sapiens 159-163 18835437-7 2009 In the vaccine/stress group, participants with larger IL-6 responses had heightened systolic blood pressure responses to tasks and elevated post-stress salivary levels of the noradrenaline metabolite 3-methoxy-phenyl glycol (MHPG) and cortisol. Hydrocortisone 235-243 interleukin 6 Homo sapiens 54-58 18775652-2 2008 Therefore, we investigated the influence of cortisol and dexamethasone on the in vitro production of TNF-alpha and IL-6 in blood cells of depressed inpatients at admission, in the course of MDD and in healthy controls. Hydrocortisone 44-52 interleukin 6 Homo sapiens 115-119 17036362-9 2006 As a biomarker of depression, IL-6 yielded at a cutoff value of 10.6 pg/mL, a sensitivity of 79%, and a specificity of 87% (area under the curve [AUC] = 0.86; 95% confidence interval [95% CI], 0.78-0.94), whereas cortisol VAR demonstrated a sensitivity of 81% and a specificity of 88% (AUC = 0.85; 95% CI, 0.74-0.97) at a cutoff value of 33.5%. Hydrocortisone 213-221 interleukin 6 Homo sapiens 30-34 18310376-10 2008 Cord blood IL-6 levels were in direct relationship with corrected adrenal volume (r=0.372, P=.019), fetal cortisol (r=0.428, P=.010), and DHEAS (r=0.521, P<.001). Hydrocortisone 106-114 interleukin 6 Homo sapiens 11-15 17706915-6 2008 RESULTS: Multilevel modeling showed that higher chronic interpersonal stress was associated with greater stimulated IL-6 production (p<0.05) as well as greater resistance to hydrocortisone inhibition of IL-6 production (p<0.05). Hydrocortisone 177-191 interleukin 6 Homo sapiens 206-210 17405871-7 2008 The cord blood cortisol concentration was significantly increased in the presence of chorioamnionitis or funisitis and was moderately correlated with cord blood IL6 (r = 0.64, p<0.01) and IL8 (r = 0.52, p<0.01). Hydrocortisone 15-23 interleukin 6 Homo sapiens 161-164 15890495-2 2006 We investigated whether the IL-6 response would habituate in response to a repetitively applied mental stressor and whether cortisol reactivity would show a relationship with IL-6 reactivity. Hydrocortisone 124-132 interleukin 6 Homo sapiens 175-179 16255036-9 2005 Interleukin-6 (IL-6) was detectable in coculture supernatants, and both IL-6 and neutrophil adhesion were reduced in a dose-dependent manner by hydrocortisone added to cocultures. Hydrocortisone 144-158 interleukin 6 Homo sapiens 0-13 16255036-9 2005 Interleukin-6 (IL-6) was detectable in coculture supernatants, and both IL-6 and neutrophil adhesion were reduced in a dose-dependent manner by hydrocortisone added to cocultures. Hydrocortisone 144-158 interleukin 6 Homo sapiens 15-19 16255036-9 2005 Interleukin-6 (IL-6) was detectable in coculture supernatants, and both IL-6 and neutrophil adhesion were reduced in a dose-dependent manner by hydrocortisone added to cocultures. Hydrocortisone 144-158 interleukin 6 Homo sapiens 72-76 15755997-11 2005 CONCLUSIONS: Significant correlations were found between serum levels of TGF-alpha and IL-6, circadian patterns in wrist activity and serum cortisol and tumor-related symptoms in patients with metastatic colorectal cancer. Hydrocortisone 140-148 interleukin 6 Homo sapiens 87-91 15253951-8 2004 Inhibition of lipopolysaccharide stimulated IL-6 and TNFalpha release by either glucocorticoid was less pronounced in samples from men than in those from women (IL-6: dexamethasone p = 0.033, hydrocortisone p = 0.029; TNFalpha: dexamethasone p < 0.001, hydrocortisone p = 0.089). Hydrocortisone 256-270 interleukin 6 Homo sapiens 44-48 15294041-4 2004 It has been demonstrated that IL-6 has many biological roles such as: (1) induction of lipolysis; (2) suppression of TNF production; (3) stimulation of cortisol production. Hydrocortisone 152-160 interleukin 6 Homo sapiens 30-34 15053241-11 2004 In stroke patients, but not in controls, IL-6 level correlated significantly with cortisol level and morning serum IL-6 level independently predicted evening/night cortisol level. Hydrocortisone 82-90 interleukin 6 Homo sapiens 41-45 16310043-10 2006 The secretion of IL-6 during day 7 of culture (standardised by taking natural logarithms) was increased markedly by the addition of TNF-alpha but unaltered by removing hydrocortisone, insulin or serum. Hydrocortisone 168-182 interleukin 6 Homo sapiens 17-21 16003055-9 2005 A dose of hydrocortisone (4 microg/kg/min for 6 hrs) that maintained plasma cortisol between 40 and 50 microg/dL, starting 60-90 mins before surgery, significantly suppressed plasma interleukin-6 after surgery compared with control while significantly increasing plasma interleukin-10 during surgery. Hydrocortisone 10-24 interleukin 6 Homo sapiens 182-195 16003055-11 2005 CONCLUSIONS: At the doses studied, cortisol-induced suppression of plasma interleukin-6 during and after cardiac surgery appears to be a saturable phenomenon at the concentration of plasma cortisol that is normally achieved after surgery in untreated patients. Hydrocortisone 35-43 interleukin 6 Homo sapiens 74-87 14563377-8 2003 Acute hydrocortisone administration suppressed TNF-alpha and IL-6 levels independently of baseline HPA system activity. Hydrocortisone 6-20 interleukin 6 Homo sapiens 61-65 12697042-7 2003 Similar to IL-6, both constitutive and IL-1beta-inducible IL-11 release were dose-dependently inhibited by cortisol (P<0.01); at variance with IL-6, exogenous IL-11 dose-dependently decreased GR numbers in MG-63 cells (P<0.05), while anti-IL-11 antibody significantly increased GR numbers in both cell lines (P<0.05). Hydrocortisone 107-115 interleukin 6 Homo sapiens 11-15