PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17314322-2	2007	Mutations in HSD11B2 result in cortisol-induced activation of mineralocorticoid receptors and cause hypertension with hypokalemia, metabolic alkalosis, and suppressed circulating renin and aldosterone concentrations.	Hydrocortisone	31-39	renin	Homo sapiens	179-184	
21114371-5	2011	Cortisol/cortisone ratio at 60(th), 120(th), 180(th), and 240(th) minute negatively correlated with basal aldosterone/plasma renin activity ratio, urinary free cortisol/24 hours and positively with basal dehydroepindrosterone sulphate.	Hydrocortisone	0-8	renin	Homo sapiens	125-130	
10726708-2	2000	Inhibition by xenobiotics such as liquorice or mutations in the HSD11 B2 gene, as occur in the rare monogenic hypertensive syndrome of apparent mineralocorticoid excess (AME), result in a compromised 11 betaHSD2 enzyme activity, which in turn leads to overstimulation of the MR by cortisol, sodium retention, hypokalaemia, low plasma renin and aldosterone concentrations, and hypertension.	Hydrocortisone	281-289	renin	Homo sapiens	334-339	
15643127-14	2005	CONCLUSION: In this study we show that low-renin essential hypertensives had increased serum cortisol/cortisone ratios as compared with normotensive subjects.	Hydrocortisone	93-101	renin	Homo sapiens	43-48	
12011658-6	2002	The in vitro regulation of renin-angiotensin system genes by hydrocortisone, insulin, thyroxin, estradiol and angiotensin II on primary cultured human mammary adipocytes was studied by quantitative reverse transcriptase polymerase chain reaction (RT-PCR).	Hydrocortisone	61-75	renin	Homo sapiens	27-32	
15743397-10	2005	Comparing values obtained following 180 min infusion of hydrocortisone and control, there were significant increases in plasma cortisol (3441 +/- 342 vs 209 +/- 29 nmol/L, respectively; P < 0.001) and glucose (5.7 +/- 0.2 vs 4.6 +/- 0.2 mmol/L, respectively; P < 0.05) and a reduction in plasma renin concentration (PRC) (8.1 +/- 1.2 vs 11.0 +/- 1.8 pg/mL, respectively; P < 0.05) following hydrocortisone infusion.	Hydrocortisone	56-70	renin	Homo sapiens	301-306	
12788846-2	2003	In a congenital deficiency of 11 beta-HSD2, the protective mechanism fails and cortisol gains inappropriate access to mineralocorticoid receptor, resulting in low-renin hypertension and hypokalemia.	Hydrocortisone	79-87	renin	Homo sapiens	163-168	
9221270-2	1995	When 11 beta-OHSD activity is impaired, cortisol acts as a potent mineralocorticoid and causes hypertension and hypokalemia with a suppression of the renin-angiotensin-aldosterone system.	Hydrocortisone	40-48	renin	Homo sapiens	150-155	
9431844-1	1997	BACKGROUND: Apparent mineralocorticoid excess (AME) is a cause of low-renin, low-aldosterone hypertension in which cortisol acts as a mineralocorticoid.	Hydrocortisone	115-123	renin	Homo sapiens	70-75	
7473517-1	1995	Studies in humans have shown that cortisol administration (200 mg/day) increases cardiac output, renal vascular resistance, glomerular filtration rate, plasma volume, extracellular fluid volume, exchangeable sodium, plasma glucose, insulin, renin substrate and atrial natriuretic peptide concentrations as well as urinary kallikrein excretion.	Hydrocortisone	34-42	renin	Homo sapiens	241-246	
2759048-5	1989	Our studies suggest that a non-renin, non-ACTH factor may influence the basal production of these steroids, and by its reduction, permits deviation of steroid substrate to cortisol production.	Hydrocortisone	172-180	renin	Homo sapiens	31-36	
9831489-1	1993	Based on urinary excretion studies the secretion of the cortisol derivatives, 18-oxocortisol and 18-hydroxycortisol are believed to be regulated by ACTH and to a lesser degree by the renin-angiotensin system.	Hydrocortisone	56-64	renin	Homo sapiens	183-188	
1914200-10	1991	Deficient or impaired 11 beta-hydroxy steroid dehydrogenase in the apparent mineralocorticoid excess syndrome or after licorice ingestion retards the conversion of cortisol to inactive cortisone in the kidney, leading to mineralocorticoid hypertension; this leads to suppression of the renin system and subsequently of aldosterone.	Hydrocortisone	164-172	renin	Homo sapiens	286-291	
35417110-6	2022	The proband was treated with hydrocortisone and 9-alpha fludrocortisone because of the significantly elevated ACTH and renin activity.	Hydrocortisone	29-43	renin	Homo sapiens	119-124	
3164727-6	1988	When hydrocortisone (10 mg daily s.c. for 4 d) was added, there was marked Na+ retention, a kaliuresis (urinary Na+/K+ falling from 1.2 to 0.15), with suppression of plasma renin activity and an increase in blood pressure.	Hydrocortisone	5-19	renin	Homo sapiens	173-178	
3164727-3	1988	The impaired conversion of cortisol to cortisone (indicated by urinary cortisol and cortisone metabolites and failure to metabolize 11 alpha-[3H]cortisol to [3H]H2O), was associated with hypertension, hypokalemia, and suppression of the renin-angiotensin-aldosterone system.	Hydrocortisone	27-35	renin	Homo sapiens	237-242	
7032816-11	1981	We conclude that the renin--angiotensin system may interact with the pituitary--adrenal axis to influence circulating levels of cortisol.	Hydrocortisone	128-136	renin	Homo sapiens	21-26	
6362571-0	1983	Fatal, low renin hypertension associated with a disturbance of cortisol metabolism.	Hydrocortisone	63-71	renin	Homo sapiens	11-16	
6277757-5	1981	An increase in 18-OH-DOC and cortisol was also observed in EH patients: in the subgroup with normal and low plasma renin activity, however, the rise in these two steroids was significantly lower than in normal subjects both under Tetracosactide and insulin.	Hydrocortisone	29-37	renin	Homo sapiens	115-120	
1150481-4	1975	In the patients who were given substitution therapy with hydrocortisone, studies of plasma renin and aldosterone revealed impairment of plasma aldosterone response to salt restriction, orthostatism and furosemide-induced diuresis combined with postural change.	Hydrocortisone	57-71	renin	Homo sapiens	91-96	
689214-0	1978	[The effect of cortisol infusion on plasma renin activity, aldosterone levels and 11-deoxycorticosterone levels in humans (author"s transl)].	Hydrocortisone	15-23	renin	Homo sapiens	43-48	
618226-0	1977	[Blood cortisol changes due to insulin hypoglycemia and serum renin dynamics in the cold pressor test in normal and hypertensive subjects].	Hydrocortisone	7-15	renin	Homo sapiens	62-67	
720700-7	1978	We concluded that the renin-angiotensin system plays an important role in the maintenance of normal or subnormal blood pressure in Addison"s disease and in the postural change of adrenalectomized patients on hydrocortisone and regular salt intake.	Hydrocortisone	208-222	renin	Homo sapiens	22-27	
211313-3	1975	Following a 9-month therapy with spironolactone episodic secretion of aldosterone and the significant correlation between aldosterone and cortisol persisted (r=0.819, p less than 0.001) in the presence of an abnormally high plasma renin activity.	Hydrocortisone	138-146	renin	Homo sapiens	231-236	
4315942-0	1970	[Action of ACTH and hydrocortisone on the renin-angiotensinogen reaction].	Hydrocortisone	20-34	renin	Homo sapiens	42-47	
33916187-7	2021	In hepatocytes, hydrocortisone increased the AGT level by accentuating the stability of mutant AGT and increasing its binding with renin.	Hydrocortisone	16-30	renin	Homo sapiens	131-136	
33916187-8	2021	Therefore, hydrocortisone may exert the therapeutic effect through the enhanced stability and interaction with renin of truncated AGT in patients carrying this AGT mutation.	Hydrocortisone	11-25	renin	Homo sapiens	111-116	
31909799-2	2020	Subtypes of essential hypertension characterized by low renin levels allowed the identification of 2 different clinical entities: aldosterone-mediated mineralocorticoid receptor (MR) activation and cortisol-mediated MR activation.	Hydrocortisone	198-206	renin	Homo sapiens	56-61