PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31816138-3 2020 The core subunits EZH1/2 are histone-lysine N-methyltransferases that function as the enzymatic component of PRC2. tyrosyl-lysine 37-43 enhancer of zeste 1 polycomb repressive complex 2 subunit Homo sapiens 18-24 31699991-0 2019 Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia. tyrosyl-lysine 8-14 enhancer of zeste 1 polycomb repressive complex 2 subunit Homo sapiens 33-37 31699991-3 2019 Here we report that AML1-ETO-positive patients, with high histone lysine methyltransferase Enhancer of zeste homolog 1 (EZH1) expression, show a worse overall survival than those with lower EZH1 expression. tyrosyl-lysine 66-72 enhancer of zeste 1 polycomb repressive complex 2 subunit Homo sapiens 120-124 31699991-5 2019 We find that EZH1 WD domain binds to the AML1-ETO NHR1 domain and methylates AML1-ETO at lysine 43 (Lys43). tyrosyl-lysine 89-95 enhancer of zeste 1 polycomb repressive complex 2 subunit Homo sapiens 13-17 31699991-8 2019 These findings highlight the role of EZH1 in non-histone lysine methylation, indicating that cooperation between AML1-ETO and EZH1 and AML1-ETO site-specific lysine methylation promote AML1-ETO transcriptional repression in leukemia. tyrosyl-lysine 57-63 enhancer of zeste 1 polycomb repressive complex 2 subunit Homo sapiens 37-41