PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27051922-9	2015	In case of immunodeficiency caused by cyclophosphamide, there was a significant decrease in IL-1beta, IL-4 and IL-6, but the introduction of phenotropil largely restored their levels.	Cyclophosphamide	38-54	interleukin 6	Rattus norvegicus	111-115	
21373362-0	2011	Increased expression of interleukin-6 family members and receptors in urinary bladder with cyclophosphamide-induced bladder inflammation in female rats.	Cyclophosphamide	91-107	interleukin 6	Rattus norvegicus	24-37	
24262494-10	2014	Up-regulated myeloperoxidase, IL-1beta, IL-6 and TNF-alpha expression in cyclophosphamide treated rats was also suppressed in rebamipide treated rats.	Cyclophosphamide	73-89	interleukin 6	Rattus norvegicus	40-44	
22961095-0	2013	Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide.	Cyclophosphamide	178-194	interleukin 6	Rattus norvegicus	15-28	
34854117-3	2022	Cyclophosphamide caused a significant increase in the activities of indoleamine 2, 3-dioxygenases (IDO), tryptophan 2, 3-dioxygenase (TDO), myeloperoxidase (MPO), and elevated the concentrations of interleukin 6 (IL-6) and interferon-gamma (IFN-gamma).	Cyclophosphamide	0-16	interleukin 6	Rattus norvegicus	198-211	
1380297-2	1992	In CY- or CBDCA-pretreated rats, significantly higher peripheral white blood cell (WBC) count was observed in animals treated with G-CSF and IL-1 alpha, while the platelet (PLT) count was elevated by IL-6 treatment.	Cyclophosphamide	3-5	interleukin 6	Rattus norvegicus	200-204	
1521924-4	1992	The effects of the anti-rheumatic drugs indometacin, dexamethasone, cyclophosphamide and cyclosporin A (CsA) on IL-6 levels during FAA were determined.	Cyclophosphamide	68-84	interleukin 6	Rattus norvegicus	112-116	
1521924-5	1992	Complete normalization of serum IL-6 levels was observed with dexamethasone, cyclophosphamide and CsA whereas indometacin only partly reduced serum IL-6 levels.	Cyclophosphamide	77-93	interleukin 6	Rattus norvegicus	32-36	
34854117-3	2022	Cyclophosphamide caused a significant increase in the activities of indoleamine 2, 3-dioxygenases (IDO), tryptophan 2, 3-dioxygenase (TDO), myeloperoxidase (MPO), and elevated the concentrations of interleukin 6 (IL-6) and interferon-gamma (IFN-gamma).	Cyclophosphamide	0-16	interleukin 6	Rattus norvegicus	213-217	
34606555-9	2021	Also, a significant prophylactic effect against liver, kidney, and heart injuries induced by CYP via decreasing inflammation (serum TNF-alpha, IL-1beta & IL-6) and lipid peroxidation (MDA) was also revealed.	Cyclophosphamide	93-96	interleukin 6	Rattus norvegicus	154-158	
35613889-10	2022	Taxifolin reduced the cyclophosphamide-induced increases in the MDA, TNF-alpha, IL-1beta, and IL-6 levels and the TOS and OSI values; it decreased the tGSH and TAS levels and reduced histopathological damage (P<0.001).	Cyclophosphamide	22-38	interleukin 6	Rattus norvegicus	94-98	
33576458-7	2021	CY administration also deactivated the cortex NF-kappaB/NLR family pyrin domain containing 3 inflammasome signaling pathway, and decreased serum TNF-alpha, IL-1beta and IL-6 concentrations.	Cyclophosphamide	0-2	interleukin 6	Rattus norvegicus	169-173	
33333050-6	2021	In addition, CYP induced marked increases in the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and nitric oxide (NO) confirmed by histological alterations.	Cyclophosphamide	13-16	interleukin 6	Rattus norvegicus	145-149	
32521683-10	2020	Additionally, the expression of ZO-2 was increased and IL-6 was decreased in the CYP plus intravesical instillation with PRP group compared with the CYP-induced acute IC/PBS group.	Cyclophosphamide	81-84	interleukin 6	Rattus norvegicus	55-59	
33333050-6	2021	In addition, CYP induced marked increases in the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and nitric oxide (NO) confirmed by histological alterations.	Cyclophosphamide	13-16	interleukin 6	Rattus norvegicus	130-143	
31356540-10	2019	Eliminating ROS with N-acetylcysteine or preinject CY into rat jugular vein reduces the expression of IL-6, TNF-a, and, especially, IL-1b in an in vivo I/R model.	Cyclophosphamide	51-53	interleukin 6	Rattus norvegicus	102-106