PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23000307-0	2012	The expression of PAC1 increases in the degenerative thymus and low dose PACAP protects female mice from cyclophosphamide induced thymus atrophy.	Cyclophosphamide	105-121	adenylate cyclase activating polypeptide 1	Mus musculus	73-78	
23000307-2	2012	In this research, firstly the thymus index and the expression of PAC1 in the normal and degenerative thymus with different gender were assayed; secondly PACAP in different dose was used to treat the female mice with cyclophosphamide (CPS) and the changes in thymus index, the expression of PAC1, histopathology, apoptosis, oxidative status and the caspase 3 activity in thymus were determined and compared.	Cyclophosphamide	216-232	adenylate cyclase activating polypeptide 1	Mus musculus	153-158	
23000307-2	2012	In this research, firstly the thymus index and the expression of PAC1 in the normal and degenerative thymus with different gender were assayed; secondly PACAP in different dose was used to treat the female mice with cyclophosphamide (CPS) and the changes in thymus index, the expression of PAC1, histopathology, apoptosis, oxidative status and the caspase 3 activity in thymus were determined and compared.	Cyclophosphamide	234-237	adenylate cyclase activating polypeptide 1	Mus musculus	153-158	
23000307-4	2012	And it was found for the first time that the PAC1 expression level in thymus of female mice was significantly higher than that of male mice and the expression of the PAC1 and PACAP increased significantly in the degenerative thymus induced by CPS.	Cyclophosphamide	243-246	adenylate cyclase activating polypeptide 1	Mus musculus	175-180	
23000307-5	2012	After PACAP was co-injected with CPS to the female mice, it was shown that only low dose (1 nmol/kg) of PACAP promoted the thymus index, inhibited the cell apoptosis, ameliorated the oxidative status and decreased the caspase activity significantly, while high dose (10 nmol/kg) of PACAP had no significant protective effects against CPS-induced thymus atrophy.	Cyclophosphamide	33-36	adenylate cyclase activating polypeptide 1	Mus musculus	104-109	
23000307-5	2012	After PACAP was co-injected with CPS to the female mice, it was shown that only low dose (1 nmol/kg) of PACAP promoted the thymus index, inhibited the cell apoptosis, ameliorated the oxidative status and decreased the caspase activity significantly, while high dose (10 nmol/kg) of PACAP had no significant protective effects against CPS-induced thymus atrophy.	Cyclophosphamide	33-36	adenylate cyclase activating polypeptide 1	Mus musculus	104-109	
23000307-5	2012	After PACAP was co-injected with CPS to the female mice, it was shown that only low dose (1 nmol/kg) of PACAP promoted the thymus index, inhibited the cell apoptosis, ameliorated the oxidative status and decreased the caspase activity significantly, while high dose (10 nmol/kg) of PACAP had no significant protective effects against CPS-induced thymus atrophy.	Cyclophosphamide	334-337	adenylate cyclase activating polypeptide 1	Mus musculus	104-109	
23000307-5	2012	After PACAP was co-injected with CPS to the female mice, it was shown that only low dose (1 nmol/kg) of PACAP promoted the thymus index, inhibited the cell apoptosis, ameliorated the oxidative status and decreased the caspase activity significantly, while high dose (10 nmol/kg) of PACAP had no significant protective effects against CPS-induced thymus atrophy.	Cyclophosphamide	334-337	adenylate cyclase activating polypeptide 1	Mus musculus	104-109	
23000307-6	2012	It was concluded that the expression of PAC1 in the thymus changes in reverse ratio with thymus index and in direct ratio with cell apoptosis and only low dose of PACAP had positive effects against the CPS-induced thymus atrophy.	Cyclophosphamide	202-205	adenylate cyclase activating polypeptide 1	Mus musculus	163-168	
20022034-2	2010	Studies show that PACAP has a role in detrusor smooth muscle contraction to facilitate adenosine triphosphate release from urothelium and PACAP antagonism decreases cyclophosphamide induced bladder hyperreflexia.	Cyclophosphamide	165-181	adenylate cyclase activating polypeptide 1	Mus musculus	138-143