PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33763830-0	2021	Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic machinery.	Cyclophosphamide	43-59	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97	
33969557-0	2021	Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats.	Cyclophosphamide	24-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	99-103	
35621844-0	2022	beta-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFkappaB and Nrf2/HO1/NQO1 Pathways.	Cyclophosphamide	31-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	109-113	
29800788-0	2018	The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: Role of Nrf2/HO-1 pathway.	Cyclophosphamide	38-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	87-91	
29800788-6	2018	Injection of Cyclo showed marked increase in serum transaminases and alkaline phosphatase, hepatic malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF- ) levels along with significant reduction in hepatic reduced glutathione (GSH), superoxide dismutase (SOD), and catalase levels in addition to downregulation of hepatic Nrf2 and HO-1 expressions and reduction in hepatic nuclear Nrf2 binding activity when compared with normal group.	Cyclophosphamide	13-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	328-332	
29800788-6	2018	Injection of Cyclo showed marked increase in serum transaminases and alkaline phosphatase, hepatic malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF- ) levels along with significant reduction in hepatic reduced glutathione (GSH), superoxide dismutase (SOD), and catalase levels in addition to downregulation of hepatic Nrf2 and HO-1 expressions and reduction in hepatic nuclear Nrf2 binding activity when compared with normal group.	Cyclophosphamide	13-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	387-391	
33169683-0	2021	Nephroprotective effect of exogenous hydrogen sulfide donor against cyclophosphamide-induced toxicity is mediated by Nrf2/HO-1/NF-kappaB signaling pathway.	Cyclophosphamide	68-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	117-121	
32066295-9	2020	Ketotifen showed a significant improvement in all parameters.Conclusion: Mast cell stabilizer, ketotifen possesses potent ameliorative effects against the hepatotoxic effect of CYC by reducing oxidative stress, inflammatory process, and apoptosis through regulation of Sirt1/Nrf2/TNF pathway.	Cyclophosphamide	177-180	NFE2 like bZIP transcription factor 2	Rattus norvegicus	275-279	
20433640-0	2010	Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat.	Cyclophosphamide	67-83	NFE2 like bZIP transcription factor 2	Rattus norvegicus	41-45