PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24064732-0	2013	Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation.	Isoflavones	0-11	sirtuin 1	Homo sapiens	99-104	
24064732-6	2013	Of interest, isoflavones induced expression of SIRT1 mRNA and phosphorylation of AMP kinase, which is well known to stimulate SIRT1 expression, although there was no direct effect on SIRT1 activation.	Isoflavones	13-24	sirtuin 1	Homo sapiens	47-52	
24064732-6	2013	Of interest, isoflavones induced expression of SIRT1 mRNA and phosphorylation of AMP kinase, which is well known to stimulate SIRT1 expression, although there was no direct effect on SIRT1 activation.	Isoflavones	13-24	sirtuin 1	Homo sapiens	126-131	
24064732-6	2013	Of interest, isoflavones induced expression of SIRT1 mRNA and phosphorylation of AMP kinase, which is well known to stimulate SIRT1 expression, although there was no direct effect on SIRT1 activation.	Isoflavones	13-24	sirtuin 1	Homo sapiens	126-131	
24064732-8	2013	These results suggest that isoflavones suppress myotube atrophy in skeletal muscle cells through activation of SIRT1 signaling.	Isoflavones	27-38	sirtuin 1	Homo sapiens	111-116	
35277012-3	2022	Nevertheless, in vitro and in vivo studies and clinical trials with humans show that the SIRT1-activating compounds derived from natural sources, such as polyphenols found in fruits, vegetables, and plants, including resveratrol, quercetin, and isoflavones, can prevent disease and be part of treatments for a wide variety of diseases.	Isoflavones	245-256	sirtuin 1	Homo sapiens	89-94	
29724067-4	2018	Several flavones and isoflavones were found as SIRT1 activators, while fluorogenic sirtuin assays utilized AMC labelled peptides as the substrates.	Isoflavones	21-32	sirtuin 1	Homo sapiens	47-52	
29724067-6	2018	We found that the reported SIRT1 activators: flavones were detected with the SIRT1 activation activity, but isoflavones were not detected with SIRT1 activation activity, and instead that they were found to be fluorogenic compounds.	Isoflavones	108-119	sirtuin 1	Homo sapiens	27-32	
18267976-6	2008	The isoflavone derivatives showed differential effects on the activation and expression of sirtuin (SIRT)1, a deacetylase and activator of PGC-1alpha.	Isoflavones	4-14	sirtuin 1	Homo sapiens	100-106	
18267976-9	2008	We have identified a series of substituted isoflavones that produce mitochondrial biogenesis through PGC1alpha and increased SIRT1 activity and/or expression, independently of the estrogen receptor.	Isoflavones	43-54	sirtuin 1	Homo sapiens	125-130	
18267976-10	2008	Furthermore, different structural components are responsible for the activities of isoflavones: the hydroxyl group at position 7 is required SIRT1 activation, a hydroxyl group at position 5 blocks SIRT1 activation, and the loss of the phenyl ring at position 3 or the 4"-hydroxy or -methoxy substituent blocks increased SIRT1 expression.	Isoflavones	83-94	sirtuin 1	Homo sapiens	141-146	
18267976-10	2008	Furthermore, different structural components are responsible for the activities of isoflavones: the hydroxyl group at position 7 is required SIRT1 activation, a hydroxyl group at position 5 blocks SIRT1 activation, and the loss of the phenyl ring at position 3 or the 4"-hydroxy or -methoxy substituent blocks increased SIRT1 expression.	Isoflavones	83-94	sirtuin 1	Homo sapiens	197-202	
18267976-10	2008	Furthermore, different structural components are responsible for the activities of isoflavones: the hydroxyl group at position 7 is required SIRT1 activation, a hydroxyl group at position 5 blocks SIRT1 activation, and the loss of the phenyl ring at position 3 or the 4"-hydroxy or -methoxy substituent blocks increased SIRT1 expression.	Isoflavones	83-94	sirtuin 1	Homo sapiens	197-202