PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28718678-0	2017	Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling.	Isoflavones	19-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49	
28718678-2	2017	In this study, we synthesised a series of novel isoflavone derivatives based on our hit compound G from in silico high-throughput screening and then tested their activities by in vitro AChE and BuChE bioassays.	Isoflavones	48-58	acetylcholinesterase (Cartwright blood group)	Homo sapiens	185-189	
28718678-3	2017	Most of the isoflavone derivatives displayed moderate inhibition against both AChE and BuChE.	Isoflavones	12-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82	
19692250-3	2009	The most potent inhibitor isoflavone derivative 10d inhibit AChE with a IC(50) of 4 nM and showed high BChE/AChE inhibition ratio (4575-fold), superior to donepezil (IC(50)=12 nM, 389-fold).	Isoflavones	26-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-64	
19692250-3	2009	The most potent inhibitor isoflavone derivative 10d inhibit AChE with a IC(50) of 4 nM and showed high BChE/AChE inhibition ratio (4575-fold), superior to donepezil (IC(50)=12 nM, 389-fold).	Isoflavones	26-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112	
18830885-4	2009	Preliminary structure-activity relationships and a molecular modeling study for 9a have revealed that the isoflavone moiety plays a key role in the interaction of this series of derivatives with AChE by acting as an anchor in its peripheral anionic site.	Isoflavones	106-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	195-199