PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12351466-3 2002 The aim of this study was to determine whether a dietary supplement with soy protein and isoflavones affected insulin resistance, glycemic control, and cardiovascular risk markers in postmenopausal women with type 2 diabetes. Isoflavones 89-100 insulin Homo sapiens 110-117 15454683-9 2004 Regulatory behaviors such as food and water intake, adipose deposition and leptin, and insulin levels affected by dietary isoflavones are also discussed. Isoflavones 122-133 insulin Homo sapiens 87-94 12654164-0 2003 Effects of supplementation with purified red clover (Trifolium pratense) isoflavones on plasma lipids and insulin resistance in healthy premenopausal women. Isoflavones 73-84 insulin Homo sapiens 106-113 34531987-1 2021 Soy isoflavones (SI) have strong estrogenic effect in tissues by binding to estrogen receptors and might be beneficial for women with polycystic ovarian syndrome (PCOS) by reduction in testosterone, cholesterol, insulin, weight gain, inflammatory markers, and oxidative stress. Isoflavones 0-15 insulin Homo sapiens 212-219 34531987-1 2021 Soy isoflavones (SI) have strong estrogenic effect in tissues by binding to estrogen receptors and might be beneficial for women with polycystic ovarian syndrome (PCOS) by reduction in testosterone, cholesterol, insulin, weight gain, inflammatory markers, and oxidative stress. Isoflavones 17-19 insulin Homo sapiens 212-219 34072748-6 2021 At the same time, a meta-analysis of the included studies revealed statistically insignificant reduction in fasting glucose, insulin, HbA1c, and HOMA-IR (changes in glucose metabolism) after consumption of soy isoflavones. Isoflavones 210-221 insulin Homo sapiens 125-132 27004555-6 2016 In addition, the effect of soy isoflavones on insulin was also significant: -0.43 muIU/mL (95% CI: -0.71 to -0.14 muIU/mL), as was the effect on homeostasis model assessment insulin resistance (HOMA-IR): -0.52 (95% CI: -0.76 to -0.28). Isoflavones 31-42 insulin Homo sapiens 46-53 33097932-1 2020 BACKGROUND: Animal studies have shown that soy protein and isoflavones can increase antioxidant capacity and improve insulin resistance, and thus ameliorate nonalcoholic fatty liver disease (NAFLD). Isoflavones 59-70 insulin Homo sapiens 117-124 30321124-3 2018 In multivariate analysis adjusted for age, sex, and drug treatments, mean 24 U isoflavone excretion was significantly inversely associated with insulin resistance in the elderly and significantly associated with blood folate and potassium in the elderly, but also positively associated with 24 U salt in the elderly. Isoflavones 79-89 insulin Homo sapiens 144-151 27490918-10 2016 CONCLUSION: Soy isoflavone administration for 12 weeks in women with PCOS significantly improved markers of insulin resistance, hormonal status, triglycerides, and biomarkers of oxidative stress. Isoflavones 16-26 insulin Homo sapiens 108-115 24875672-8 2014 Further, high-isoflavone consumers were protected against inflammation-induced decline in insulin sensitivity (SI) in GENE. Isoflavones 14-24 insulin Homo sapiens 90-97 25382603-9 2015 When soya product intake was calculated as soya protein and isoflavone, the odds ratios of insulin resistance decreased significantly as the estimated intake of soya protein increased. Isoflavones 60-70 insulin Homo sapiens 91-98 25660477-0 2015 Amelioration of oxidative stress and insulin resistance by soy isoflavones (from Glycine max) in ovariectomized Wistar rats fed with high fat diet: the molecular mechanisms. Isoflavones 63-74 insulin Homo sapiens 37-44 25660477-9 2015 Taken together, these findings emphasized the antioxidant property and anti-diabetic effects of soy isoflavones suggesting the use of this natural phytoestrogen as a strategy for relieving oxidative stress and insulin resistance in postmenopausal women. Isoflavones 100-111 insulin Homo sapiens 210-217 26163627-10 2015 CONCLUSIONS: Decreased serum isoflavones levels, such as those for daidzein and glycitein, decreased serum adiponectin levels, and increased serum insulin levels could be shown to be associated with elevated risk of ovarian cancer. Isoflavones 29-40 insulin Homo sapiens 147-154 23776073-8 2013 An isoflavone mixture similar to that found in serum of HF-SPI rats significantly increased in vitro osteoblast proliferation and blocked significantly reduced NEFA-induced insulin resistance. Isoflavones 3-13 insulin Homo sapiens 173-180 20335543-1 2010 BACKGROUND: In vitro and animal studies have suggested that soy protein and isoflavones have favorable effects on glucose and insulin regulation, but intervention studies in humans are limited, and the results are controversial. Isoflavones 76-87 insulin Homo sapiens 126-133 22191384-0 2012 Soy isoflavones improve insulin sensitivity without changing serum leptin among postmenopausal women. Isoflavones 0-15 insulin Homo sapiens 24-31 22191384-1 2012 OBJECTIVE: To investigate the effect of a soy isoflavone extract over insulin sensitivity and plasma leptin levels. Isoflavones 46-56 insulin Homo sapiens 70-77 22250063-0 2012 Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: a 1-year, double-blind, randomized, controlled trial. Isoflavones 38-49 insulin Homo sapiens 59-66 22858192-1 2013 OBJECTIVE: The objective of this study was to conduct a systematic review and a meta-analysis to confirm the effects of soy isoflavone supplementation on body weight, fasting glucose, and insulin level in non-Asian postmenopausal women. Isoflavones 124-134 insulin Homo sapiens 188-195 22858192-9 2013 CONCLUSIONS: This meta-analysis showed soy isoflavone supplementation could be beneficial for body weight reduction, glucose, and insulin control in plasma. Isoflavones 39-53 insulin Homo sapiens 130-137 21280205-6 2011 A screening of representative flavonoids of different structural classes revealed the flavanone naringenin and the isoflavone daidzein to affect glucose transport significantly with half-maximal inhibition at concentrations of around 60-80 muM for basal and 70-110 muM for insulin-stimulated glucose uptake in both 3T3-L1 adipocytes and mature human adipocytes. Isoflavones 115-125 insulin Homo sapiens 273-280 21197412-1 2010 We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDL-C, HDL-C, glucose, insulin, uric acid, C-reactive protein, fibrinogen, and homocysteine. Isoflavones 25-36 insulin Homo sapiens 270-277 19484707-2 2009 Soy is a good source of protein and also contains isoflavones that may affect plasma lipids, body weight, and insulin action. Isoflavones 50-61 insulin Homo sapiens 110-117 20116654-5 2010 Nutritional studies performed in animals and intervention studies with humans suggest that the ingestion of soy protein with isoflavones improves glucose control and reduces insulin resistance. Isoflavones 125-136 insulin Homo sapiens 174-181 20216276-0 2010 Soy isoflavones, Mediterranean diet, and physical exercise in postmenopausal women with insulin resistance. Isoflavones 0-15 insulin Homo sapiens 88-95 20216276-1 2010 OBJECTIVE: The aim of this study was to evaluate whether a standard dose of 40 mg of soy isoflavones prescribed in routine clinical practice for treatment of menopausal symptoms has some influence on glucose homeostasis in postmenopausal women with insulin resistance (IR). Isoflavones 89-100 insulin Homo sapiens 249-256 20432816-1 2010 AIMS: To evaluate for the first time in children the effect of soy-derived isoflavones on lipid profile and insulin resistance. Isoflavones 75-86 insulin Homo sapiens 108-115 19076553-11 2008 Isoflavones were found to have a positive effect on insulin resistance and cardiovascular outcome measures, but only when combined with soy proteins. Isoflavones 0-11 insulin Homo sapiens 52-59 18555850-1 2008 Isoflavones may influence insulin action by means of their well-known receptor-mediated estrogenic activity. Isoflavones 0-11 insulin Homo sapiens 26-33 18555850-2 2008 However, isoflavones also bind to peroxisome proliferator-activated receptors (PPARs) that are strongly associated with insulin action. Isoflavones 9-20 insulin Homo sapiens 120-127 18555850-3 2008 Soy protein with its isoflavones has previously been shown to improve glycemic control in diabetic postmenopausal women and to improve insulin sensitivity in ovariectomized monkeys. Isoflavones 21-32 insulin Homo sapiens 135-142 18555850-4 2008 The purpose of the current report was to extend our studies of dietary soy protein to male monkeys and determine effects of the soy isoflavones on insulin resistance. Isoflavones 132-143 insulin Homo sapiens 147-154 18555850-12 2008 The major findings were that consumption of isoflavone-containing soy protein dose-dependently increased insulin responses to the glucose challenge and decreased plasma adiponectin, whereas isoflavone-depleted soy protein decreased body weight and had no effect on plasma adiponectin concentrations. Isoflavones 44-54 insulin Homo sapiens 105-112 19083434-0 2008 High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates. Isoflavones 5-15 insulin Homo sapiens 35-42 19083434-1 2008 Consuming soy and soy isoflavones has been shown to cause modest improvements in plasma lipids, lipoproteins, and indices of insulin sensitivity in postmenopausal women. Isoflavones 22-33 insulin Homo sapiens 125-132 19083434-7 2008 We show that high isoflavones do not adversely affect insulin sensitivity but do significantly alter insulin secretion to glucose stimulation. Isoflavones 18-29 insulin Homo sapiens 101-108 15650341-8 2004 RESULTS: Two-way ANOVA revealed that fasting glucose (p < 0.001) and insulin (p < 0.005) levels were significantly affected by estrogen and isoflavone treatments after 6 months. Isoflavones 146-156 insulin Homo sapiens 72-79 15650341-10 2004 Within the same periods, the fasting blood glucose was reduced to 83% and 85% of the baseline levels, and insulin was reduced to 56% and 67% of the baseline levels, respectively, in the estrogen and isoflavone groups. Isoflavones 199-209 insulin Homo sapiens 106-113 15650341-11 2004 CONCLUSIONS: Soy isoflavones (100 mg) and 0.625 mg conjugated estrogen equally lower fasting blood glucose and insulin levels in postmenopausal women. Isoflavones 17-28 insulin Homo sapiens 111-118 15585205-1 2005 OBJECTIVE: Isoflavone supplementation in high doses is associated with plasma lipid, glucose and insulin levels. Isoflavones 11-21 insulin Homo sapiens 97-104