PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10901693-8	2000	With amitriptyline as the substrate, N-glucuronidation kinetics in the absence of detergent were biphasic in human liver microsomes and monophasic with a high K(M) value in cell homogenates containing UGT1A4.	Amitriptyline	5-18	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	201-207	
12404680-9	2002	The olanzapine glucuronidation reaction was inhibited by several drugs known as substrates for UGT1A4, e.g. amitriptyline, trifluoperazine and lamotrigine.	Amitriptyline	108-121	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	95-101	
20133892-2	2010	The apparent K(m) (S(50)) values for the formation of quaternary N-glucuronides of amitriptyline, imipramine, clomipramine, and trimipramine were 2.60, 16.8, 14.4, and 11.2 microM in UGT2B10 and 448, 262, 112, and 258 microM in UGT1A4, respectively.	Amitriptyline	83-96	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	228-234	
20133892-3	2010	The kinetics of amitriptyline and imipramine glucuronidation in human liver microsomes exhibited a biphasic character, where the high- and low-affinity components were in good agreement with our results in expressed UGT2B10 and UGT1A4, respectively.	Amitriptyline	16-29	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	228-234