PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34093211-0	2021	Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients.	Amitriptyline	95-108	solute carrier family 22 member 1	Homo sapiens	87-91	
34093211-11	2021	In a second, independent study sample of 50 patients who underwent amitriptyline therapy of 75 mg twice daily, a significant trend of increasing amitriptyline plasma concentrations with decreasing OCT1 activity was observed (p = 0.018), while nortriptyline plasma concentrations were unaffected by the OCT1 genotype.	Amitriptyline	67-80	solute carrier family 22 member 1	Homo sapiens	197-201	
34093211-11	2021	In a second, independent study sample of 50 patients who underwent amitriptyline therapy of 75 mg twice daily, a significant trend of increasing amitriptyline plasma concentrations with decreasing OCT1 activity was observed (p = 0.018), while nortriptyline plasma concentrations were unaffected by the OCT1 genotype.	Amitriptyline	145-158	solute carrier family 22 member 1	Homo sapiens	197-201	
34093211-3	2021	Here, the impact of OCT1 genetic variation on the pharmacokinetics of amitriptyline and its active metabolite nortriptyline was studied in vitro as well as in healthy volunteers and in depressive disorder patients.	Amitriptyline	70-83	solute carrier family 22 member 1	Homo sapiens	20-24	
34093211-4	2021	Amitriptyline and nortriptyline were found to inhibit OCT1 in recombinant cells with IC50 values of 28.6 and 40.4 microM.	Amitriptyline	0-13	solute carrier family 22 member 1	Homo sapiens	54-58	
30361780-7	2018	All of the six drugs examined, including amitriptyline, fluoxetine, imipramine, irinotecan, ondansetron, and verapamil, were inhibitors of OCT1/2-mediated morphine uptake.	Amitriptyline	41-54	solute carrier family 22 member 1	Homo sapiens	139-143	
22913740-5	2014	Known inhibitors of hOCT1 and hOCT2 activities such as verapamil, amitriptyline, prazosin, and quinine were next demonstrated to decrease rhodamine 123 accumulation in hOCT1- and hOCT2-overexpressing HEK293 cells.	Amitriptyline	66-79	solute carrier family 22 member 1	Homo sapiens	20-25	
22913740-5	2014	Known inhibitors of hOCT1 and hOCT2 activities such as verapamil, amitriptyline, prazosin, and quinine were next demonstrated to decrease rhodamine 123 accumulation in hOCT1- and hOCT2-overexpressing HEK293 cells.	Amitriptyline	66-79	solute carrier family 22 member 1	Homo sapiens	168-173	
22806583-6	2012	At their upper therapeutic plasma concentrations, several drugs are expected to inhibit by more than 20 % hOCT1 and could thus interfere with the pharmacokinetics of hOCT1-transported drugs in the kidney and liver, namely trimipramine, desipramine and fluoxetine (by about 37 %), levomepromazine and nefazodone (by about 32 %), and clozapine and amitriptyline (by about 22 %).	Amitriptyline	346-359	solute carrier family 22 member 1	Homo sapiens	106-111	
22806583-6	2012	At their upper therapeutic plasma concentrations, several drugs are expected to inhibit by more than 20 % hOCT1 and could thus interfere with the pharmacokinetics of hOCT1-transported drugs in the kidney and liver, namely trimipramine, desipramine and fluoxetine (by about 37 %), levomepromazine and nefazodone (by about 32 %), and clozapine and amitriptyline (by about 22 %).	Amitriptyline	346-359	solute carrier family 22 member 1	Homo sapiens	166-171	
20567254-8	2011	Concomitantly administered drugs, such as verapamil and amitriptyline, revealed potential drug-drug interactions at clinical plasma concentrations of metformin for OCT1-M420del.	Amitriptyline	56-69	solute carrier family 22 member 1	Homo sapiens	164-168