PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24090215-3	2013	Virus replication inhibitory assays in vitro of these triazole derivatives containing either an amino or guanidino function indicated that the guanidinium compound showed the higher efficacy against a strain with N2 subtype at a concentration of 2 x 10(-5) M but did not inhibit replication of a strain with N1 subtype even at a concentration of 10(-4) M. In order to probe the nature of the enzyme-inhibitor interactions, molecular dynamics simulations were performed on complexes of these compounds with different neuraminidase enzymes.	Guanidine	143-154	neuraminidase 1	Homo sapiens	516-529	
3491010-3	1986	When subjected to Sephacryl S-300 gel filtration, urinary neuraminidase showed a single peak of activity with an apparent molecular weight of 380,000 daltons, even under denaturing conditions (6 M guanidine hydrochloride).	Guanidine	197-220	neuraminidase 1	Homo sapiens	58-71	
518302-3	1979	The effect of guanidine at various molarities showed that the neuraminidase was more sensitive than the hemagglutinin and a selective inactivation was obtained after exposure to 1.5 M guanidine.	Guanidine	14-23	neuraminidase 1	Homo sapiens	62-75	
518302-3	1979	The effect of guanidine at various molarities showed that the neuraminidase was more sensitive than the hemagglutinin and a selective inactivation was obtained after exposure to 1.5 M guanidine.	Guanidine	184-193	neuraminidase 1	Homo sapiens	62-75	
518302-4	1979	However differences in sensitivity of both activities (hemagglutinin and neuraminidase) to heat and guanidine inactivations were observed among strains and correlated with differential susceptibility to non-specific inhibitors of the strains.	Guanidine	100-109	neuraminidase 1	Homo sapiens	73-86	
4799156-0	1973	Differential effect of guanidine hydrochloride and heat on the haemagglutinin and neuraminidase of influenza viruses.	Guanidine	23-46	neuraminidase 1	Homo sapiens	82-95	
21778065-2	2011	Guanidino-oseltamivir (GO) is another effective neuraminidase inhibitor with polar guanidinium group under physiological conditions.	Guanidine	83-94	neuraminidase 1	Homo sapiens	48-61	
22001088-1	2011	The guanidine function in the potent neuraminidase inhibitor peramivir was included early on in the drug design process, and examination of X-ray structural data for the enzyme-inhibitor complex would seem to indicate that the guanidine plays a critical role in promoting binding.	Guanidine	4-13	neuraminidase 1	Homo sapiens	37-50	
22001088-1	2011	The guanidine function in the potent neuraminidase inhibitor peramivir was included early on in the drug design process, and examination of X-ray structural data for the enzyme-inhibitor complex would seem to indicate that the guanidine plays a critical role in promoting binding.	Guanidine	227-236	neuraminidase 1	Homo sapiens	37-50