PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9149684-0 1997 Endothelin-1 upregulation in the kidney of uninephrectomized spontaneously hypertensive rats and its modification by the angiotensin-converting enzyme inhibitor quinapril. Quinapril 161-170 endothelin 1 Rattus norvegicus 0-12 9176845-0 1997 Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis. Quinapril 0-9 endothelin 1 Rattus norvegicus 26-38 9176845-4 1997 In a normotensive model of immune-complex nephritis, in which there exists an increase in renal ACE activity, the effect of the ACE inhibitor quinapril on preproET-1 and ETA receptor mRNA expression, as well as on ET-1 protein levels, was examined in this study. Quinapril 142-151 endothelin 1 Rattus norvegicus 161-165 9176845-8 1997 The administration of the ACE inhibitor quinapril decreased proteinuria and morphological lesions, preproET-1 gene transcription, and ET-1 protein levels, as well as the ETA receptor mRNA. Quinapril 40-49 endothelin 1 Rattus norvegicus 105-109 9176845-9 1997 The results from this study show that in a normotensive model of immune-complex nephritis, there was an overexpression of ET-1 in several structures of the kidney that was downregulated by quinapril administration. Quinapril 189-198 endothelin 1 Rattus norvegicus 122-126 11708846-9 2001 Four weeks of therapy with quinapril attenuated the positive inotropic effects of ET-1 and prevented the increase in ET-A receptor mRNA. Quinapril 27-36 endothelin 1 Rattus norvegicus 82-86