PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19667110-5 2009 In the pravastatin group, the triallelic rs2032582 variant (G2677T/A) in ABCB1 was associated with the percent reduction in LDL-C (GG 23.3%, non-G heterozygote 20.3%, and non-G homozygote 17.4%, P=0.042). Pravastatin 7-18 ATP binding cassette subfamily B member 1 Homo sapiens 73-78 21820929-6 2012 RESULTS: CYP3A4 was responsible for the metabolism of lovastatin, simvastatin and atorvastatin; fluvastatin depends on CYP2C9; P-glycoprotein is responsible for decreased atorvastatin, pravastatin, simvastatin and lovastatin concentrations. Pravastatin 185-196 ATP binding cassette subfamily B member 1 Homo sapiens 127-141 19667110-7 2009 Polymorphisms in triallelic G2677T/A variant in ABCB1 were associated with the degree of LDL-C lowering with pravastatin. Pravastatin 109-120 ATP binding cassette subfamily B member 1 Homo sapiens 48-53 19694740-1 2009 AIMS: This study aimed to investigate possible effects of ABCB1 genotype on fluvastatin, pravastatin, lovastatin, and rosuvastatin pharmacokinetics. Pravastatin 89-100 ATP binding cassette subfamily B member 1 Homo sapiens 58-63 16722833-0 2006 Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes. Pravastatin 33-44 ATP binding cassette subfamily B member 1 Homo sapiens 200-205 16722833-1 2006 AIMS: Our aim was to investigate associations between the single nucleotide polymorphisms (SNPs) in the SLCO1B1 (encoding OATP1B1) and ABCB1 (encoding P-glycoprotein) genes with the pharmacokinetics and efficacy of pravastatin in children with heterozygous familial hypercholesterolaemia (HeFH) and in paediatric cardiac transplant recipients. Pravastatin 215-226 ATP binding cassette subfamily B member 1 Homo sapiens 135-140 17923246-11 2007 Addition of a HMG-CoA reductase inhibitor to KG1a cells resulted in an additional 26% (lovastatin, p = 0.03) and 16% (pravastatin, p = 0.05) reduction in pgp, respectively. Pravastatin 118-129 ATP binding cassette subfamily B member 1 Homo sapiens 154-157