PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12504868-6 2003 In addition, DNA-binding activities of NF-kappaB, AP-1, and CREB in the frontal cortex and hippocampus were more pronounced in mice injected with Tat plus METH compared to the effects of Tat or METH alone. Methamphetamine 155-159 cAMP responsive element binding protein 1 Mus musculus 60-64 31078920-14 2019 Moreover, phosphorylation of ERK1/2 and CREB was increased after METH and LPS exposure but decreased by SCH-23390. Methamphetamine 65-69 cAMP responsive element binding protein 1 Mus musculus 40-44 12237866-4 2002 Significant and dose-dependent inductions of AP-1 and CREB DNA-binding activities were observed in four different regions (striatum, frontal cortex, hippocampus, and cerebellum) isolated from the brains of mice injected with METH. Methamphetamine 225-229 cAMP responsive element binding protein 1 Mus musculus 54-58 12237866-6 2002 These results suggest that METH-induced oxidative stress may trigger the molecular signaling pathways via specific and selective activation of AP-1 and CREB. Methamphetamine 27-31 cAMP responsive element binding protein 1 Mus musculus 152-156 32777257-10 2020 The detection of gene expression by RT-PCR indicated that METH-sensitized mice exhibited decreased levels of Fas, MEK1 and CREB and increased levels of Erk1/2 in the PFC. Methamphetamine 58-62 cAMP responsive element binding protein 1 Mus musculus 123-127 32777257-11 2020 Western blot analysis revealed decreased Fas, GIT1, MEK1 and phosphorylated CREB levels and increased phosphorylated Erk1/2 levels in METH-sensitized mice. Methamphetamine 134-138 cAMP responsive element binding protein 1 Mus musculus 76-80 11038257-1 2000 Possible direct effects of methamphetamine (METH) on transcription factors AP-1 and cAMP response element-binding protein (CREB) in the nucleus were assessed by electrophoretic mobility-shift assay. Methamphetamine 27-42 cAMP responsive element binding protein 1 Mus musculus 84-121 11038257-1 2000 Possible direct effects of methamphetamine (METH) on transcription factors AP-1 and cAMP response element-binding protein (CREB) in the nucleus were assessed by electrophoretic mobility-shift assay. Methamphetamine 27-42 cAMP responsive element binding protein 1 Mus musculus 123-127 11038257-1 2000 Possible direct effects of methamphetamine (METH) on transcription factors AP-1 and cAMP response element-binding protein (CREB) in the nucleus were assessed by electrophoretic mobility-shift assay. Methamphetamine 44-48 cAMP responsive element binding protein 1 Mus musculus 84-121 11038257-1 2000 Possible direct effects of methamphetamine (METH) on transcription factors AP-1 and cAMP response element-binding protein (CREB) in the nucleus were assessed by electrophoretic mobility-shift assay. Methamphetamine 44-48 cAMP responsive element binding protein 1 Mus musculus 123-127 11038257-3 2000 In addition, injections of METH to mice induced increases in the binding of AP-1 and CREB, which were depleted by preincubating the nuclear extract with anti-METH antibody. Methamphetamine 27-31 cAMP responsive element binding protein 1 Mus musculus 85-89 11038257-3 2000 In addition, injections of METH to mice induced increases in the binding of AP-1 and CREB, which were depleted by preincubating the nuclear extract with anti-METH antibody. Methamphetamine 158-162 cAMP responsive element binding protein 1 Mus musculus 85-89 33203971-6 2020 Methamphetamine treatment inhibits Sigmar1, resulting in inactivation of the cAMP response element-binding protein (CREB), decreased expression of mitochondrial fission 1 protein (FIS1), and ultimately alteration of mitochondrial dynamics and function. Methamphetamine 0-15 cAMP responsive element binding protein 1 Mus musculus 77-114 33203971-6 2020 Methamphetamine treatment inhibits Sigmar1, resulting in inactivation of the cAMP response element-binding protein (CREB), decreased expression of mitochondrial fission 1 protein (FIS1), and ultimately alteration of mitochondrial dynamics and function. Methamphetamine 0-15 cAMP responsive element binding protein 1 Mus musculus 116-120 32777257-14 2020 CONCLUSION: The findings indicated that the development of behavioural sensitization to METH may be mediated by Fas and GIT1 through the MEK1-Erk1/2-CREB pathway. Methamphetamine 88-92 cAMP responsive element binding protein 1 Mus musculus 149-153 29981334-8 2018 These data indicate that the increased GluN2b expression, and p-ERK and p-CREB levels in the NAc of AAV-shRNA-mTrx-1 mice may be responsible for the METH-primed reinstatement. Methamphetamine 149-153 cAMP responsive element binding protein 1 Mus musculus 74-78 30544074-7 2019 Combined, our data show that withdrawal from chronic METH exposure induces anxiety and depression-like behavior associated with aberrant changes of proteins in BDNF-ERK-CREB pathway, providing new evidence for the involvement of BDNF pathway in the negative emotional states induced by withdrawal from METH. Methamphetamine 53-57 cAMP responsive element binding protein 1 Mus musculus 169-173 29414647-0 2018 Methamphetamine modulates the production of interleukin-6 and tumor necrosis factor-alpha via the cAMP/PKA/CREB signaling pathway in lipopolysaccharide-activated microglia. Methamphetamine 0-15 cAMP responsive element binding protein 1 Mus musculus 107-111 29414647-11 2018 Both the concentration of cAMP and the phosphorylation of CREB were increased by METH in LPS-activated microglial cells. Methamphetamine 81-85 cAMP responsive element binding protein 1 Mus musculus 58-62 29414647-14 2018 These results suggest that the differential regulation of IL-6 and TNF-alpha by METH in LPS-activated microglial cells may be attributable to the cAMP/PKA/CREB signaling pathway. Methamphetamine 80-84 cAMP responsive element binding protein 1 Mus musculus 155-159 26300473-8 2015 METH-induced prolonged increases in Fosb, Fra2, Egr1, and Egr3 mRNA levels in HDAC2KO mice were associated with increased enrichment of phosphorylated CREB (pCREB) on the promoters of these genes. Methamphetamine 0-4 cAMP responsive element binding protein 1 Mus musculus 151-155 28782589-9 2018 These results suggest that overexpression of Trx-1 may occlude the CPP induced by METH through regulating the activity of CREB and the expression of DeltaFosB. Methamphetamine 82-86 cAMP responsive element binding protein 1 Mus musculus 122-126 28319198-8 2017 We found that METH activates CREB binding to the Shati/Nat8L promoter to induce the Shati/Nat8L mRNA expression. Methamphetamine 14-18 cAMP responsive element binding protein 1 Mus musculus 29-33 28319198-11 2017 These results showed that the Shati/Nat8L mRNA was increased by METH-induced CREB pathway via dopamine D1 receptor signaling in mouse NAc. Methamphetamine 64-68 cAMP responsive element binding protein 1 Mus musculus 77-81 23159329-0 2013 Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex. Methamphetamine 18-33 cAMP responsive element binding protein 1 Mus musculus 145-149 23159329-9 2013 In contrast, activation of both ERK and CREB in the PFC was found following memory retrieval but not other processes in METH-treated mouse groups. Methamphetamine 120-124 cAMP responsive element binding protein 1 Mus musculus 40-44 23159329-11 2013 Moreover, activation of the ERK and CREB signaling pathway in the hippocampus might be involved in METH-induced spatial memory changes. Methamphetamine 99-103 cAMP responsive element binding protein 1 Mus musculus 36-40 21738744-7 2011 Furthermore, Western blot analysis and quantitative real-time reverse transcription polymerase chain reaction demonstrated that ICER overexpression abolished the METH-induced increase in CREB expression and repressed cocaine- and amphetamine-regulated transcript (CART) and prodynorphin (Pdyn) expression in mice. Methamphetamine 162-166 cAMP responsive element binding protein 1 Mus musculus 187-191