PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10764309-6 2000 There were inverse correlations between Pa(O(2)) and circulating TNF-alpha and sTNF-R levels in patients with COPD (TNF-alpha; r = -0.426, p = 0.0297; sTNF-R55: r = -0.587, p = 0.0027; sTNF-R75: r = -0.573, p = 0.0035). Protactinium 40-42 tumor necrosis factor Homo sapiens 65-74 10764309-6 2000 There were inverse correlations between Pa(O(2)) and circulating TNF-alpha and sTNF-R levels in patients with COPD (TNF-alpha; r = -0.426, p = 0.0297; sTNF-R55: r = -0.587, p = 0.0027; sTNF-R75: r = -0.573, p = 0.0035). Protactinium 40-42 tumor necrosis factor Homo sapiens 116-125 7558248-3 1995 Although TNF-alpha suppresses the induced increase in steady-state mRNA levels of u-PA and PAI-1 during maturation of extracellular matrix (ECM), the u-PA/PAI-1 ratio is altered in such a way that PA activity associated with the ECM is higher than control cells. Protactinium 84-86 tumor necrosis factor Homo sapiens 9-18 8886888-9 1996 In all patients the serum TNF-alpha levels in PA-blood were temporarily elevated following IPHP from less than 10 pg/ml before IPHP to 42.8 +/- 26.6 pg/ml; endotoxin levels were not altered. Protactinium 46-48 tumor necrosis factor Homo sapiens 26-35 1597474-8 1992 We found that interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) upregulated PA activity in A549 human pulmonary epithelial cells. Protactinium 101-103 tumor necrosis factor Homo sapiens 49-76 1597474-8 1992 We found that interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) upregulated PA activity in A549 human pulmonary epithelial cells. Protactinium 101-103 tumor necrosis factor Homo sapiens 78-87 32495128-8 2020 After HCT116 cells were treated with palmitate acid (PA) and/or TNF-alpha for 24 h, the combination of PA and TNF-alpha increased ROS production, promoted mitochondrial dysfunction, and activated the pro-apoptotic pathway, but these effects were markedly attenuated by a ROS inhibitor. Protactinium 53-55 tumor necrosis factor Homo sapiens 110-119 2107884-14 1990 Whereas TNF and bacterial lipopolysaccharide (LPS) have similar effects on the production of PA inhibitor by human endothelial cells, LPS has no or only a relatively small effect on the fibrinolytic properties of mesothelial cells. Protactinium 93-95 tumor necrosis factor Homo sapiens 8-11 33975149-9 2021 RESULTS: Controlling for negative affect, body mass index, age, and sex, PA significantly moderated the associations between sleep condition and stimulated monocyte production of IL-6 (b = -1.03, t = -2.02, p = .048) and its co-expression with TNF (b = -0.93, t = -2.00, p = .049), such that inflammatory responses were blunted among those high in PA with increases principally among those low in PA. Protactinium 73-75 tumor necrosis factor Homo sapiens 244-247 32495128-8 2020 After HCT116 cells were treated with palmitate acid (PA) and/or TNF-alpha for 24 h, the combination of PA and TNF-alpha increased ROS production, promoted mitochondrial dysfunction, and activated the pro-apoptotic pathway, but these effects were markedly attenuated by a ROS inhibitor. Protactinium 103-105 tumor necrosis factor Homo sapiens 64-73 29164820-3 2018 METHODS & RESULTS: HepG2 cells treated with palmitic acid (PA;0.75 mM) showed decreased expression of various antioxidant biomarkers (SOD1, SOD2, glutathione peroxidase and catalase) and increased expression of inflammatory markers (TNFalpha, IL1beta and IL6). Protactinium 63-65 tumor necrosis factor Homo sapiens 237-245 32894459-5 2020 Cytokine production under the influence of PA was different only in case of TNF-alpha in all study groups. Protactinium 43-45 tumor necrosis factor Homo sapiens 76-85 22300412-4 2012 We present a case of PA as a complication of underlying psoriasis, which developed during tumour necrosis factor (TNF)-alpha inhibitor therapy for Crohn disease. Protactinium 21-23 tumor necrosis factor Homo sapiens 90-124 28379594-20 2017 PA + EtOH-treated cells increased TNF-alpha levels in media compared to EtOH alone [86+-8 vs. 53+-5 pg/mL in cells exposed to 100 mmol/L EtOH (p<0.05) and 218+-14 vs. 179+-8 pg/mL in cells exposed to 2x100 mmol/L EtOH (p<0.05)]. Protactinium 0-2 tumor necrosis factor Homo sapiens 34-43 26202921-10 2015 MAIN RESULTS AND THE ROLE OF CHANCE: The long chain saturated fatty acids, stearic and palmitic (PA), stimulated the synthesis as well as the release of TNF-alpha, IL-6 and IL-8 by trophoblast cells (2- to 6-fold, P < 0.001). Protactinium 97-99 tumor necrosis factor Homo sapiens 153-162 26202921-13 2015 LIMITATIONS, REASONS FOR CAUTION: TNF-alpha protein level was close to the limit of detection in the culture medium even when cells were cultured with PA. Protactinium 151-153 tumor necrosis factor Homo sapiens 34-43 25185133-8 2014 Notably, TNF-alpha short hairpin small-interfering RNA prevented the cold-induced increases in TNF-alpha, interleukin-6, and phosphodiesterase-1C protein expression, abolished lung macrophage infiltration, and attenuated PH (26.28+-1.6 mm Hg), PA remodeling, and right ventricle hypertrophy. Protactinium 244-246 tumor necrosis factor Homo sapiens 9-18 25185133-12 2014 AAV delivery of TNF-alpha short hairpin small-interfering RNA may be an effective therapeutic approach for cold-induced PH and PA remodeling. Protactinium 127-129 tumor necrosis factor Homo sapiens 16-25 22654787-8 2010 In the PA group, TNF-alpha concentration was not associated with metabolic-endocrine features, but high IL-6 was associated with lower birth weight. Protactinium 7-9 tumor necrosis factor Homo sapiens 17-26 22100620-3 2012 In our previous reports, we have conclusively established the Calreticulin Transacetylase (CRTAase) catalyzed activation of neuronal nitric oxide synthase (nNOS) and tumor necrosis factor-alpha (TNF-alpha) induced nitric oxide synthase (iNOS) by PA. Protactinium 246-248 tumor necrosis factor Homo sapiens 166-193 22100620-3 2012 In our previous reports, we have conclusively established the Calreticulin Transacetylase (CRTAase) catalyzed activation of neuronal nitric oxide synthase (nNOS) and tumor necrosis factor-alpha (TNF-alpha) induced nitric oxide synthase (iNOS) by PA. Protactinium 246-248 tumor necrosis factor Homo sapiens 195-204 21657246-8 2011 The unmodified PA:PVP membranes drastically increased the level of TNF-alpha; however, the concentration of IL-1beta and IL-6 remained almost the same. Protactinium 15-17 tumor necrosis factor Homo sapiens 67-76 22654787-10 2010 In conclusion, PA was associated with increased serum TNF-alpha concentrations which, unexpectedly, were not connected with BMI or insulin resistance. Protactinium 15-17 tumor necrosis factor Homo sapiens 54-63 18664531-9 2008 At baseline, the PA group had a lower percentage of CD14+CD16+ monocytes and lower unstimulated production of TNF-alpha than the PI group. Protactinium 17-19 tumor necrosis factor Homo sapiens 110-119 15224966-7 2004 Additionally, it has been found that in mitochondria of the TNF (tumor necrosis factor)-sensitive cells (WEHI-164 line), the content of PA is larger than in mitochondria of the TNF-insensitive cells (C6 line), with this difference being mainly provided by PA incorporated in phosphatidylethanolamine and especially, cardiolipin. Protactinium 136-138 tumor necrosis factor Homo sapiens 60-63 15224966-7 2004 Additionally, it has been found that in mitochondria of the TNF (tumor necrosis factor)-sensitive cells (WEHI-164 line), the content of PA is larger than in mitochondria of the TNF-insensitive cells (C6 line), with this difference being mainly provided by PA incorporated in phosphatidylethanolamine and especially, cardiolipin. Protactinium 136-138 tumor necrosis factor Homo sapiens 65-86 15224966-7 2004 Additionally, it has been found that in mitochondria of the TNF (tumor necrosis factor)-sensitive cells (WEHI-164 line), the content of PA is larger than in mitochondria of the TNF-insensitive cells (C6 line), with this difference being mainly provided by PA incorporated in phosphatidylethanolamine and especially, cardiolipin. Protactinium 256-258 tumor necrosis factor Homo sapiens 60-63 15224966-7 2004 Additionally, it has been found that in mitochondria of the TNF (tumor necrosis factor)-sensitive cells (WEHI-164 line), the content of PA is larger than in mitochondria of the TNF-insensitive cells (C6 line), with this difference being mainly provided by PA incorporated in phosphatidylethanolamine and especially, cardiolipin. Protactinium 256-258 tumor necrosis factor Homo sapiens 65-86