PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8550736-12 1996 Net PA activity reflects the balance between PA and PAI-1. Protactinium 4-6 serpin family E member 1 Homo sapiens 52-57 10397301-4 1999 Endothelial cells (ECs) synthesize fibrinolytic proteins, t-PA, u-PA, and PAs inhibitor, PAI-1. Protactinium 74-77 serpin family E member 1 Homo sapiens 89-94 16054502-7 2005 Recent observations suggest that PAI-1, the main inhibitor of PAs, shows greater expression in the isthmus compared to the ampulla and the local generation of plasmin is inhibited. Protactinium 62-65 serpin family E member 1 Homo sapiens 33-38 11376560-3 2001 Among the PA system factors, both the levels of uPAR and PAI-1 were significantly higher in larger tumors than in smaller ones, and were also significantly higher in tumors that invaded subserosa, serosa or adjacent organs than in mucosal, submucosal tumors or in tumors that invaded the muscle layer. Protactinium 10-12 serpin family E member 1 Homo sapiens 57-62 7599699-2 1995 Endometrial cells are known to release a major PA inhibitor, PAI-1. Protactinium 47-49 serpin family E member 1 Homo sapiens 61-66 8772230-9 1995 PA activity, identified as u-PA by functional and immunological criteria, was measured in CM of six of the eight u-PA producing cell lines, whereas PAI activity was undetectable or very low in CM of all cell lines, suggesting that PAI-1 was largely inactive. Protactinium 0-2 serpin family E member 1 Homo sapiens 231-236 7611439-7 1995 Plasminogen activator inhibitor-1 (PAI-1) inhibited PA activity of preformed uPA/uPAR complexes and increased cycling of the receptor from the cell surface. Protactinium 35-37 serpin family E member 1 Homo sapiens 0-33 8052969-7 1994 Fibrin zymographic analysis of affinity-purified tPA-like-PA demonstrated a major and a minor fibrin lysis zone, which approximately corresponded to the tPA-like-PA and its complex with PAI-1 observed by Western blots. Protactinium 50-52 serpin family E member 1 Homo sapiens 186-191 8052969-7 1994 Fibrin zymographic analysis of affinity-purified tPA-like-PA demonstrated a major and a minor fibrin lysis zone, which approximately corresponded to the tPA-like-PA and its complex with PAI-1 observed by Western blots. Protactinium 57-60 serpin family E member 1 Homo sapiens 186-191 8052969-9 1994 We conclude that platelets contain a functionally active tPA-like-PA, whose low fibrinolytic activity might be due to its readily forming a complex with PAI-1. Protactinium 65-68 serpin family E member 1 Homo sapiens 153-158 8130729-2 1993 The two types of plasminogen activator, tissue-type (tPA) and urokinase-type (uPA), are produced by osteoblasts, as is the specific PA inhibitor, PAI-1. Protactinium 54-56 serpin family E member 1 Homo sapiens 146-151 8130729-3 1993 Some hormones which activate bone resorption increase PA activity produced by osteoblasts, by decreasing the production of PAI-1. Protactinium 54-56 serpin family E member 1 Homo sapiens 123-128 8130729-6 1993 TGF beta itself is a powerful inhibitor of PA activity, an effect achieved by enhancing mRNA and protein for PAI-1. Protactinium 43-45 serpin family E member 1 Homo sapiens 109-114 8242773-5 1993 Since monocyte/macrophage PA activity is likely to be important in tissue remodeling and cell migration at sites of inflammation and in fibrinolysis, it is proposed from these studies that PAI-1, as well as the usually considered PAI-2, may be involved in the negative control of PA activity in this cell type. Protactinium 26-28 serpin family E member 1 Homo sapiens 189-194 1520875-14 1992 Therefore, heparin, at therapeutic concentrations, may enhance or stabilize the association of PAs with endothelial cell-associated PAI-1. Protactinium 95-98 serpin family E member 1 Homo sapiens 132-137 8508786-3 1993 Using gonadotropin-induced ovulation as a model, we have studied how two components of the PA system, tissue-type plasminogen activator (tPA) and plasminogen-activator-inhibitor type 1 (PAI-1), are regulated temporally and spatially by gonadotropins, leading to the initiation and termination of a well-directed proteolytic process. Protactinium 91-93 serpin family E member 1 Homo sapiens 146-184 1662315-8 1991 Zymographic analysis of secreted PA related compounds revealed production of free urokinase (u-PA) and type 1 plasminogen activator inhibitor (PAI-1) complexed to tissular plasminogen activator (t-PA). Protactinium 33-35 serpin family E member 1 Homo sapiens 143-148 2363126-6 1990 The PAI appears to bind to the carboxy-terminal chain of both PAs, because the part of the band corresponding to the carboxy-terminal chain of PAs moved to an upper position as a result of complex formation when two-chain form of PAs were incubated with the PAI and analyzed by SDS-PAGE followed by immunoblotting. Protactinium 62-65 serpin family E member 1 Homo sapiens 4-7 1801752-3 1991 Zymographic analysis by using fibrin agar indicator gels indicated that part of the PA activity in culture supernatants of the HaCaT line is complexed with putative PA inhibitors (PAI). Protactinium 84-86 serpin family E member 1 Homo sapiens 165-178 1801752-3 1991 Zymographic analysis by using fibrin agar indicator gels indicated that part of the PA activity in culture supernatants of the HaCaT line is complexed with putative PA inhibitors (PAI). Protactinium 84-86 serpin family E member 1 Homo sapiens 180-183 2213017-2 1990 These cells also produce and secrete the endothelial cell-type PA inhibitor (PAI-1), which forms sodium dodecyl sulfate-stable tPA/PAI-1 complexes in the culture medium. Protactinium 63-65 serpin family E member 1 Homo sapiens 77-82 2213017-2 1990 These cells also produce and secrete the endothelial cell-type PA inhibitor (PAI-1), which forms sodium dodecyl sulfate-stable tPA/PAI-1 complexes in the culture medium. Protactinium 63-65 serpin family E member 1 Homo sapiens 131-136 2113968-2 1990 Species of PAs and PAI secreted from the GECs were urokinase-type PA (u-PA) and tissue-type PA (t-PA), while the major species was a single chain u-PA in the amount of 28.6 +/- 2.34 ng/10(5) cells for 24 hours (N = 4, mean +/- SD), and PAI-1. Protactinium 11-14 serpin family E member 1 Homo sapiens 236-241 2363126-6 1990 The PAI appears to bind to the carboxy-terminal chain of both PAs, because the part of the band corresponding to the carboxy-terminal chain of PAs moved to an upper position as a result of complex formation when two-chain form of PAs were incubated with the PAI and analyzed by SDS-PAGE followed by immunoblotting. Protactinium 62-65 serpin family E member 1 Homo sapiens 258-261 2363126-6 1990 The PAI appears to bind to the carboxy-terminal chain of both PAs, because the part of the band corresponding to the carboxy-terminal chain of PAs moved to an upper position as a result of complex formation when two-chain form of PAs were incubated with the PAI and analyzed by SDS-PAGE followed by immunoblotting. Protactinium 143-146 serpin family E member 1 Homo sapiens 4-7 2363126-6 1990 The PAI appears to bind to the carboxy-terminal chain of both PAs, because the part of the band corresponding to the carboxy-terminal chain of PAs moved to an upper position as a result of complex formation when two-chain form of PAs were incubated with the PAI and analyzed by SDS-PAGE followed by immunoblotting. Protactinium 143-146 serpin family E member 1 Homo sapiens 258-261 2363126-6 1990 The PAI appears to bind to the carboxy-terminal chain of both PAs, because the part of the band corresponding to the carboxy-terminal chain of PAs moved to an upper position as a result of complex formation when two-chain form of PAs were incubated with the PAI and analyzed by SDS-PAGE followed by immunoblotting. Protactinium 143-146 serpin family E member 1 Homo sapiens 4-7 2363126-6 1990 The PAI appears to bind to the carboxy-terminal chain of both PAs, because the part of the band corresponding to the carboxy-terminal chain of PAs moved to an upper position as a result of complex formation when two-chain form of PAs were incubated with the PAI and analyzed by SDS-PAGE followed by immunoblotting. Protactinium 143-146 serpin family E member 1 Homo sapiens 258-261 34084717-3 2021 The PA effect was not obvious in amelanotic melanoma, but was seen in melanotic melanoma by PA imaging (PAI) and histopathological correlation in cases of primary melanotic melanoma accompanied by metastatic lymph nodes, including the coexistence of amelanotic melanoma and melanotic melanoma. Protactinium 4-6 serpin family E member 1 Homo sapiens 104-107 2105930-8 1990 Thus, both wild-type rt-PA and S478A rt-PA interact with the HUVEC monolayer through PAI-1. Protactinium 24-26 serpin family E member 1 Homo sapiens 85-90 34084717-3 2021 The PA effect was not obvious in amelanotic melanoma, but was seen in melanotic melanoma by PA imaging (PAI) and histopathological correlation in cases of primary melanotic melanoma accompanied by metastatic lymph nodes, including the coexistence of amelanotic melanoma and melanotic melanoma. Protactinium 92-94 serpin family E member 1 Homo sapiens 104-107 20943061-5 2010 The expression of the components of the PA system, including uPA, its type-1 and type-2 inhibitors (PAI-1 and PAI-2) and its receptor (uPAR), was examined by Western blot in fibroblasts from patients affected by limited and diffuse forms of SSc. Protactinium 40-42 serpin family E member 1 Homo sapiens 100-105 2513300-4 1989 The serological specificities of the IF-negative/PA-positive specimens were tested by using a newly developed PA inhibition (PAI) test. Protactinium 110-112 serpin family E member 1 Homo sapiens 125-128 2513300-6 1989 Sixty of the 104 specimens collected randomly from the IF-negative/PA-positive donors were PAI-positive. Protactinium 67-69 serpin family E member 1 Homo sapiens 91-94 23232596-3 2013 The results show that, under irradiation at 254 nm and independently of the presence of oxygen, the predominant reaction pathway is a photo-Fries rearrangement (PFR), yielding the PA isomer 2"-amino-5"-hydroxyacetophenone (PAI). Protactinium 180-182 serpin family E member 1 Homo sapiens 223-226 2514093-8 1989 Kinetic analysis demonstrated that the procaryote-produced PAI-1 had an inhibitory activity towards all three forms of PA that resembled that of natural PAI-1 with association rate constants of approximately 10(7) M-1 s-1. Protactinium 59-61 serpin family E member 1 Homo sapiens 153-158 33837678-2 2021 For PA imaging (PAI), non-ideal signal detection deteriorates image quality, and quantitative PAI (QPAI) remains challenging due to the unknown light fluence spectra in deep tissue. Protactinium 4-6 serpin family E member 1 Homo sapiens 16-19 32406216-4 2020 AIM: The aim of this study is to derive an effective PA absorption spectrum of collagen to select the optimal wavelength for high-sensitive PA imaging (PAI). Protactinium 53-55 serpin family E member 1 Homo sapiens 152-155 32406216-4 2020 AIM: The aim of this study is to derive an effective PA absorption spectrum of collagen to select the optimal wavelength for high-sensitive PA imaging (PAI). Protactinium 140-142 serpin family E member 1 Homo sapiens 152-155 32406216-9 2020 Thereby, the PA signal increased by up to five times compared with the wavelength commonly used in collagen PAI. Protactinium 13-15 serpin family E member 1 Homo sapiens 108-111