PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34738406-6	2021	Compared with the NC group, the PA group showed decreased cell viability and MMP(P<0.01, P<0.01), elevated apoptosis(P<0.01), and up-regulated phosphorylated levels of p38, ERK1/2, and JNK1/2(P<0.01, P<0.01, P<0.01).	Protactinium	32-34	mitogen-activated protein kinase 1	Homo sapiens	168-171	
34431177-5	2021	Propranolol used to inhibit PA hydrolysis triggers this pathway, which then activates p38 and ERK1/2 downstream PKA inhibition.	Protactinium	28-30	mitogen-activated protein kinase 1	Homo sapiens	86-89	
34738406-7	2021	Compared with the PA group, the GXZT-H, GXZT-M, and GXZT-L groups showed increased cell viability and MMP(P<0.01, P<0.01, P<0.01), reduced apoptosis(P<0.01), and down-regulated protein expression and phosphorylated levels of p38, ERK1/2 and JNK1/2 in the MAPK signaling pathway(P<0.01, P<0.01, P<0.01).	Protactinium	18-20	mitogen-activated protein kinase 1	Homo sapiens	225-228	
33051821-10	2020	All these data implicated that JAB1 knockdown might alleviate PA-induced IR through ERK pathway in hepatocytes.	Protactinium	62-64	mitogen-activated protein kinase 1	Homo sapiens	84-87	
25776488-7	2015	Combination with PA and IR also increased the production of ROS, which subsequently induced phosphorylation of p38, suppressed phosphorylation of ERK, and activated caspase-3, -8, and -9.	Protactinium	17-19	mitogen-activated protein kinase 1	Homo sapiens	146-149	
25776488-10	2015	Collectively, these results indicate that PA functions as a radiosensitizer by enhancing apoptosis through activation of a ROS/p38/caspase pathway and suppression of ERK.	Protactinium	42-44	mitogen-activated protein kinase 1	Homo sapiens	166-169	
24550275-6	2014	The majority of residues in active ERK2 fit to a single conformational exchange process, with kex   300 s(-1) (kAB   240 s(-1)/kBA   60 s(-1)) and pA/pB   20%/80%, suggesting global domain motions involving interconversion between two states.	Protactinium	147-149	mitogen-activated protein kinase 1	Homo sapiens	35-39	
24550275-7	2014	A mutant of ERK2, engineered to enhance conformational mobility at the hinge region linking the N- and C-terminal domains, also induced two-state conformational exchange throughout the kinase core, with exchange properties of kex   500 s(-1) (kAB   15 s(-1)/kBA   485 s(-1)) and pA/pB   97%/3%.	Protactinium	279-281	mitogen-activated protein kinase 1	Homo sapiens	12-16	
24554201-3	2014	Nevertheless, the most important causative factors seem to be NF1 gene inactivation, in cases related to neurofibromatosis type 1, and BRAF gene overexpression in sporadic PAs, both resulting in MAPK/Erk pathway upregulation.	Protactinium	172-175	mitogen-activated protein kinase 1	Homo sapiens	195-199	
17592174-11	2007	In conclusion, the inhibitory effect of PA, SA, DHA, and EPA on lymphocyte proliferation observed in our previous study was attributable to a decrease in JAK/STAT, ERK, and Akt pathways activated by IL-2.	Protactinium	40-42	mitogen-activated protein kinase 1	Homo sapiens	164-167	
9009157-10	1997	Our data demonstrate an interaction between PA and the MAPK signalling pathway and suggest that the latter may be involved in ODC-induced transformation of mammary epithelial cells.	Protactinium	44-46	mitogen-activated protein kinase 1	Homo sapiens	55-59