PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10801075-3 2000 The data obtained demonstrate that the growth factor activity of PAs is associated with: - a rapid transient activation of early response genes, c-fos, c-jun and c-myc; - the subsequent coordinated down-regulation of p53 and p21CIP1; - the constant expression of the MEK1 mRNA in every phase of the cell cycle. Protactinium 65-68 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 152-157