PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31895687-9	2019	Ubenimex inhibits the activation of the CD13/EMP3/PI3K/AKT/NF-kappaB pathway to overcome CDDP resistance in GC cells by suppressing autophagy and epithelial-mesenchymal transition (EMT).	ubenimex	0-8	AKT serine/threonine kinase 1	Homo sapiens	55-58	
31895687-0	2019	Ubenimex induces autophagy inhibition and EMT suppression to overcome cisplatin resistance in GC cells by perturbing the CD13/EMP3/PI3K/AKT/NF-kappaB axis.	ubenimex	0-8	AKT serine/threonine kinase 1	Homo sapiens	136-139	
30915355-7	2019	In addition, Ubenimex downregulates expression of membrane transport proteins, such as P-gp and MRP1, by inhibiting phosphorylation in the PI3K/AKT/mTOR pathway to increase intracellular accumulations of 5-fluorouracil and oxaliplatin, a process for which downregulation of CD13 expression is essential.	ubenimex	13-21	AKT serine/threonine kinase 1	Homo sapiens	144-147	
28484091-0	2017	Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells.	ubenimex	0-8	AKT serine/threonine kinase 1	Homo sapiens	99-102	
29328441-0	2018	Ubenimex, an APN inhibitor, could serve as an anti-tumor drug in RT112 and 5637 cells by operating in an Akt-associated manner.	ubenimex	0-8	AKT serine/threonine kinase 1	Homo sapiens	105-108	
29328441-15	2018	Treatment with ubenimex was accompanied by decreased Akt expression, indicating that ubenimex may have similar functions to Akt inhibitors.	ubenimex	15-23	AKT serine/threonine kinase 1	Homo sapiens	53-56	
29328441-15	2018	Treatment with ubenimex was accompanied by decreased Akt expression, indicating that ubenimex may have similar functions to Akt inhibitors.	ubenimex	15-23	AKT serine/threonine kinase 1	Homo sapiens	124-127	
29328441-15	2018	Treatment with ubenimex was accompanied by decreased Akt expression, indicating that ubenimex may have similar functions to Akt inhibitors.	ubenimex	85-93	AKT serine/threonine kinase 1	Homo sapiens	53-56	
29503569-13	2018	Moreover, treatment with ubenimex induced protective Akt activation, and combined use of an Akt inhibitor with ubenimex provided a better effect for inducing tumor cell death.	ubenimex	25-33	AKT serine/threonine kinase 1	Homo sapiens	53-56	
29503569-14	2018	Conclusion: As an effective anti-tumor drug in vitro, ubenimex might be an excellent adjunctive therapy for the treatment of melanoma, with greater effects when combined with the use of an Akt inhibitor.	ubenimex	54-62	AKT serine/threonine kinase 1	Homo sapiens	189-192	
28484091-8	2017	Since ubenimex was verified as an Akt inhibitor, we further studied the role of Akt inhibition in regulating JQ1 sensitivity and migration of glioma cells.	ubenimex	6-14	AKT serine/threonine kinase 1	Homo sapiens	34-37	
28484091-11	2017	Our findings suggest the potential of ubenimex adjuvant treatment to enhance JQ1 efficiency and attenuate parts of its side effect (enhancing tumor aggressive) by regulating the autophagic degradation of HEXIM1 and Akt inhibition.	ubenimex	38-46	AKT serine/threonine kinase 1	Homo sapiens	215-218	
27816967-0	2016	Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism.	ubenimex	0-8	AKT serine/threonine kinase 1	Homo sapiens	88-91	
27816967-7	2016	In sorafenib-resistant cells, ubenimex inhibited the Akt signaling pathway that regulates autophagy.	ubenimex	30-38	AKT serine/threonine kinase 1	Homo sapiens	53-56	
27900012-15	2016	An Akt agonist could significantly weaken this effect, indicating that ubenimex may act as an Akt inhibitor.	ubenimex	71-79	AKT serine/threonine kinase 1	Homo sapiens	3-6	
27900012-15	2016	An Akt agonist could significantly weaken this effect, indicating that ubenimex may act as an Akt inhibitor.	ubenimex	71-79	AKT serine/threonine kinase 1	Homo sapiens	94-97	
27900012-16	2016	Furthermore, the western blot analysis indicated that the combined treatment inhibited the Akt signaling pathway compared with ubenimex treatment or IR alone.	ubenimex	127-135	AKT serine/threonine kinase 1	Homo sapiens	91-94