PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11311111-6	2001	Later approaches utilized known inhibitors of related zinc-containing metalloproteinases and led to the identification of captopril, bestatin and kelatorphan as potent inhibitors of LTA4 hydrolase.	ubenimex	133-141	leukotriene A4 hydrolase	Homo sapiens	182-196	
14515987-5	2003	Bestatin--originally known as an aminopeptidase inhibitor--was employed as guiding structure for the development of leukotriene A4 hydrolase inhibitors.	ubenimex	0-9	leukotriene A4 hydrolase	Homo sapiens	116-140	
15134534-5	2004	Bestatin, an LTA4H inhibitor, suppresses tumorigenesis in this animal model.	ubenimex	0-8	leukotriene A4 hydrolase	Homo sapiens	13-18	
7575672-4	1995	Of the metalloproteinase inhibitors examined, only captopril, bestatin, and fosinoprilat had appreciable inhibitory activity for LTA4 hydrolase in disrupted epithelial cells.	ubenimex	62-70	leukotriene A4 hydrolase	Homo sapiens	129-143	
27299562-0	1996	Synthesis of Bestatin, a Potent Inhibitor of Leukotriene A4 Hydrolase, by an N3 Nucleophile Reaction to a Non-protected Diol.	ubenimex	13-21	leukotriene A4 hydrolase	Homo sapiens	45-69	
7575672-5	1995	Concentration-inhibition curves to captopril, bestatin, and fosinoprilat revealed IC50 values of 430 microM, 7 microM, and 1 mM, respectively, for disrupted-cell LTA4 hydrolase activity.	ubenimex	46-54	leukotriene A4 hydrolase	Homo sapiens	162-176	
7575672-7	1995	LTA4 hydrolase concentration-inhibition curves examined in intact cells with captopril, bestatin, and 1,10-O-phenanthroline revealed IC50 values of 63, 70, and 920 microM, respectively.	ubenimex	88-96	leukotriene A4 hydrolase	Homo sapiens	0-14	
8106755-5	1994	Their activities were inhibited by bestatin and captopril, and they were completely absorbed by anti-human LTA4 hydrolase antibody.	ubenimex	35-43	leukotriene A4 hydrolase	Homo sapiens	107-121	
7893649-5	1995	Leukotriene A4 hydrolase could be protected from inactivation by these tyrosyl and arginyl reagents by the competitive inhibitors bestatin and captopril, respectively.	ubenimex	130-138	leukotriene A4 hydrolase	Homo sapiens	0-24	
7667299-7	1995	Furthermore, both enzyme inactivation and peptide modification could be prevented by preincubation of LTA4 hydrolase with the competitive inhibitor bestatin, which demonstrates that the henicosapeptide contains functional elements of the active site(s).	ubenimex	148-156	leukotriene A4 hydrolase	Homo sapiens	102-116	
1312948-0	1992	Bestatin inhibits covalent coupling of [3H]LTA4 to human leukocyte LTA4 hydrolase.	ubenimex	0-8	leukotriene A4 hydrolase	Homo sapiens	67-81	
7694703-5	1993	The specific lipoxygenase inhibitor, AA-861 (0.1-10 microM), inhibited PAF-activated histamine release, while the leukotriene A4 hydrolase inhibitor, bestatin (100 microM), had only a marginal effect.	ubenimex	150-158	leukotriene A4 hydrolase	Homo sapiens	114-138	
32580506-5	2020	A hybrid 3D structure-based pharmacophore model was generated based on the crystal structure of LTA4H in complex with bestatin.	ubenimex	118-126	leukotriene A4 hydrolase	Homo sapiens	96-101	
31085102-8	2019	FINDINGS: Samples from 13 CRC patients showed a significant decrease in LTB4, the LTA4H signaling pathway, and Ki-67 in the bestatin-treated group compared with the untreated group.	ubenimex	124-132	leukotriene A4 hydrolase	Homo sapiens	82-87	
20952510-8	2010	Notably, resveratrol exerted relatively stronger inhibitory effects than bestatin, an established inhibitor of LTA(4)H activity, and the inhibitory effects of resveratrol were reduced in cells where LTA(4)H was suppressed by shRNA-mediated knockdown.	ubenimex	73-81	leukotriene A4 hydrolase	Homo sapiens	111-118	
20952510-8	2010	Notably, resveratrol exerted relatively stronger inhibitory effects than bestatin, an established inhibitor of LTA(4)H activity, and the inhibitory effects of resveratrol were reduced in cells where LTA(4)H was suppressed by shRNA-mediated knockdown.	ubenimex	73-81	leukotriene A4 hydrolase	Homo sapiens	199-206	
20631848-1	2010	Bestatin, a small molecular weight dipeptide, is a potent inhibitor of various aminopeptidases as well as LTA4 hydrolase.	ubenimex	0-8	leukotriene A4 hydrolase	Homo sapiens	106-120