PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30758914-10 2019 ALA treatment decreased ROS production in UPM-exposed fibroblasts via the Nrf2, HO-1, and NQO-1 pathways. Thioctic Acid 0-3 heme oxygenase 1 Homo sapiens 80-84 31877176-0 2019 alpha-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway. Thioctic Acid 0-17 heme oxygenase 1 Homo sapiens 85-89 31319135-5 2019 Reduced expression of NADPH dehydrogenase quinone 1 (NQO-1) and heme oxygenase 1 (HO-1) genes, which are well-characterized downstream targets of Nrf2-mediated transactivation, was also confirmed by using ALA and another Nrf2 activator, marliolide. Thioctic Acid 205-208 heme oxygenase 1 Homo sapiens 64-80 31319135-5 2019 Reduced expression of NADPH dehydrogenase quinone 1 (NQO-1) and heme oxygenase 1 (HO-1) genes, which are well-characterized downstream targets of Nrf2-mediated transactivation, was also confirmed by using ALA and another Nrf2 activator, marliolide. Thioctic Acid 205-208 heme oxygenase 1 Homo sapiens 82-86 28366867-8 2017 5muM Cd2+ exposure significantly augmented nuclear Nrf2, GSH and GCLC, GCLM, HMOX1, TNFalpha and IL-6 mRNA expression but not GSR, however these upsurges were significantly abrogated by ALA or 1muM Cd2+ pre-treatments. Thioctic Acid 186-189 heme oxygenase 1 Homo sapiens 77-82 30039754-3 2018 Nutraceutical measures which may address these issues include taurine and N-acetylcysteine - which may boost placental H2S production; spirulina and phase 2 inducers of heme oxygenase-1 such as lipoic acid - which may down-regulate placental NADPH oxidase activity; and citrulline, high-dose folate, and dietary nitrate - which by supporting placental nitric oxide production may aid proper placentation and hence prevent placental hypoxia. Thioctic Acid 194-205 heme oxygenase 1 Homo sapiens 169-185 26765462-4 2016 Addition of ALA strongly attenuated ROS production and further increased HO-1 expression. Thioctic Acid 12-15 heme oxygenase 1 Homo sapiens 73-77 26765462-5 2016 However, by pretreatment of zinc protoporphyrin (ZnPP), HO-1 inhibitor, ALA inhibition of ROS generation by H2O2 was abolished. Thioctic Acid 72-75 heme oxygenase 1 Homo sapiens 56-60 23573137-0 2013 The protective effect of alpha-lipoic Acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase-1. Thioctic Acid 25-42 heme oxygenase 1 Homo sapiens 106-122 26414010-8 2015 Alpha-lipoic acid, an oxidative stress inhibitor, prevented the development of superoxide acutely and increased antiapoptotic markers B-cell lymphoma 2 (t = 3.079, P < 0.05) and heme oxygenase 1 (t = 8.169, P < 0.001) after single blast. Thioctic Acid 0-17 heme oxygenase 1 Homo sapiens 181-197 26043815-0 2015 Lipoic acid and N-acetylcysteine prevent ammonia-induced inflammatory response in C6 astroglial cells: The putative role of ERK and HO1 signaling pathways. Thioctic Acid 0-11 heme oxygenase 1 Homo sapiens 132-135 26003724-0 2015 Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1. Thioctic Acid 76-87 heme oxygenase 1 Homo sapiens 110-126 23573137-6 2013 Interestingly, treatment with ALA significantly increased nuclear factor-erythroid 2-related factor 2 (Nrf2) activation and HO-1 expression in lungs of ALI. Thioctic Acid 30-33 heme oxygenase 1 Homo sapiens 124-128 23573137-7 2013 However, blocking HO-1 activity by tin protoporphyrin IX (SnPP), an HO-1 inhibitor, markedly abolished these beneficial effects of ALA in LPS-induced ALI. Thioctic Acid 131-134 heme oxygenase 1 Homo sapiens 18-22 23573137-7 2013 However, blocking HO-1 activity by tin protoporphyrin IX (SnPP), an HO-1 inhibitor, markedly abolished these beneficial effects of ALA in LPS-induced ALI. Thioctic Acid 131-134 heme oxygenase 1 Homo sapiens 68-72 23573137-8 2013 These results suggest that the protection mechanism of ALA may be through HO-1 induction and in turn suppressing NF- kappa B-mediated inflammatory responses. Thioctic Acid 55-58 heme oxygenase 1 Homo sapiens 74-78 25325059-8 2014 Induction of heme oxygenase-1, which can be attained with phase 2 inducer phytochemicals such as lipoic acid and green tea catechins, promotes reverse cholesterol transport in macrophages and inhibits atherogenesis in rodents, likely due to, in large part, NF-kappaB antagonism. Thioctic Acid 97-108 heme oxygenase 1 Homo sapiens 13-29 25093998-0 2014 Effects of aspirin & simvastatin and aspirin, simvastatin, & lipoic acid on heme oxygenase-1 in healthy human subjects. Thioctic Acid 69-80 heme oxygenase 1 Homo sapiens 84-100 25093998-4 2014 Our aims were to compare the effects of placebo, aspirin, and simvastatin alone, and with alpha-lipoic acid, on HO-1 protein concentration and activity in humans. Thioctic Acid 90-107 heme oxygenase 1 Homo sapiens 112-116 23573137-3 2013 The aim of study was to test the hypothesis that the protection of ALA against lipopolysaccharide-(LPS-) induced acute lung injury (ALI) is mediated by HO-1. Thioctic Acid 67-70 heme oxygenase 1 Homo sapiens 152-156 16123320-0 2005 Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Thioctic Acid 0-17 heme oxygenase 1 Homo sapiens 26-42 21315065-0 2011 Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages. Thioctic Acid 0-11 heme oxygenase 1 Homo sapiens 49-53 17917164-1 2007 In this study, we evaluated the effect of lipoic acid (LA) and N-acetyl cysteine (NAC) on oxidative [4-hydroxy-2-nonenal, N(epsilon)-(carboxymethyl)lysine and heme oxygenase-1] and apoptotic (caspase 9 and Bax) markers in fibroblasts from patients with Alzheimer disease (AD) and age-matched and young controls. Thioctic Acid 42-53 heme oxygenase 1 Homo sapiens 159-175 16631521-0 2006 Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein kinase in vascular smooth muscle cells. Thioctic Acid 54-71 heme oxygenase 1 Homo sapiens 0-16 16631521-4 2006 ALA significantly induced HO-1 expression accompanied by an increase in HO activity in A10 cells. Thioctic Acid 0-3 heme oxygenase 1 Homo sapiens 26-30 16631521-7 2006 ALA significantly increased ROS, and this effect was blocked by N-acetyl-cysteine, which also inhibited ALA-induced activation of p44/42 mitogen-activated protein kinase (MAPK) and AP-1, HO-1 expression, and HO activity. Thioctic Acid 0-3 heme oxygenase 1 Homo sapiens 187-191 16631521-7 2006 ALA significantly increased ROS, and this effect was blocked by N-acetyl-cysteine, which also inhibited ALA-induced activation of p44/42 mitogen-activated protein kinase (MAPK) and AP-1, HO-1 expression, and HO activity. Thioctic Acid 104-107 heme oxygenase 1 Homo sapiens 187-191 16631521-8 2006 These results suggest that ALA induces HO-1 expression through the production of ROS and subsequent activation of the p44/42 MAPK pathway and AP-1 in vascular smooth muscle cells. Thioctic Acid 27-30 heme oxygenase 1 Homo sapiens 39-43 16631521-9 2006 This study demonstrated that ALA increases the expression of HO-1, a critical cytoprotective molecule, and identified a novel pleiotropic effect of ALA on cardiovascular protection. Thioctic Acid 29-32 heme oxygenase 1 Homo sapiens 61-65 16123320-10 2005 Pretreatment with SB203580, a p38 mitogen-activated protein kinase inhibitor, reduced ALA-induced HO-1 mRNA expression by 75% and inhibited ALA-induced Nrf2 binding to the HO-1 ARE. Thioctic Acid 86-89 heme oxygenase 1 Homo sapiens 98-102 16123320-10 2005 Pretreatment with SB203580, a p38 mitogen-activated protein kinase inhibitor, reduced ALA-induced HO-1 mRNA expression by 75% and inhibited ALA-induced Nrf2 binding to the HO-1 ARE. Thioctic Acid 86-89 heme oxygenase 1 Homo sapiens 172-176 16123320-10 2005 Pretreatment with SB203580, a p38 mitogen-activated protein kinase inhibitor, reduced ALA-induced HO-1 mRNA expression by 75% and inhibited ALA-induced Nrf2 binding to the HO-1 ARE. Thioctic Acid 140-143 heme oxygenase 1 Homo sapiens 172-176 16123320-11 2005 CONCLUSIONS: These results demonstrate that ALA induces HO-1 expression in THP-1 monocytic cells via Nrf2 and p38. Thioctic Acid 44-47 heme oxygenase 1 Homo sapiens 56-60 16123320-12 2005 Further studies are required to investigate whether the protective effects of ALA in monocytes are mediated by HO-1. Thioctic Acid 78-81 heme oxygenase 1 Homo sapiens 111-115 16123320-5 2005 This study examined the effects of ALA on HO-1 expression in human monocytic cells. Thioctic Acid 35-38 heme oxygenase 1 Homo sapiens 42-46 16123320-6 2005 METHODS AND RESULTS: ALA time and dose-dependently induced HO-1 mRNA expression in THP-1 cells, with peak expression at 4 hours and returning to baseline by 24 hours. Thioctic Acid 21-24 heme oxygenase 1 Homo sapiens 59-63 16123320-8 2005 ALA stimulated translocation of the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) into the nucleus and binding to a human HO-1 antioxidant response element (ARE) by 30 minutes. Thioctic Acid 0-3 heme oxygenase 1 Homo sapiens 148-152 16123320-9 2005 A dominant-negative Nrf2 inhibitor reduced ALA-induced HO-1 mRNA expression by 66%. Thioctic Acid 43-46 heme oxygenase 1 Homo sapiens 55-59 34118221-10 2021 This study suggests that ALA priming may improve the therapeutic potential of ADSCs against chronic liver problems by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream antioxidant factors heme oxygenase 1 (HO-1) and quinone acceptor oxidoreductase-1 (NQO1). Thioctic Acid 25-28 heme oxygenase 1 Homo sapiens 223-239 34118221-10 2021 This study suggests that ALA priming may improve the therapeutic potential of ADSCs against chronic liver problems by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream antioxidant factors heme oxygenase 1 (HO-1) and quinone acceptor oxidoreductase-1 (NQO1). Thioctic Acid 25-28 heme oxygenase 1 Homo sapiens 241-245