PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35069862-4 2022 Using a computational docking program and examination of AKT and TAK1 level changes, a new small molecule was identified, 2-benzoyl-3-hydroxy-4-methyl-9H-xanthen-9-one, which competitively bound to TRAF6. 2-benzoyl-3-hydroxy-4-methyl-9h-xanthen-9-one 122-167 LOC222344 Homo sapiens 198-203 35069862-9 2022 These findings indicated that 2-benzoyl-3-hydroxy-4-methyl-9H-xanthen-9-one could induce apoptosis by inhibiting the activation of AKT and TAK1, and affecting the Bcl-2/Bax-caspase-9-caspase-3 pathway by competitively binding with TRAF6. 2-benzoyl-3-hydroxy-4-methyl-9h-xanthen-9-one 30-75 LOC222344 Homo sapiens 231-236