PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17868322-2	2007	Examination of the mechanism by which NMDA modulates the phosphorylation of protein phosphatase inhibitor-1 at Ser6 and Ser67 and dopamine- and cAMP-regulated phosphoprotein M(r) 32 000 at Thr75 revealed that generalized depolarization, rather than specific activation of NMDA receptors, was sufficient to induce decreases in these Cdk5 sites.	N-Methylaspartate	38-42	cyclin dependent kinase 5	Homo sapiens	332-336	
17868322-7	2007	Thus, in the striatum the regulation of phosphorylation of Cdk5-dependent sites by NMDA occurs through multiple distinct pathways.	N-Methylaspartate	83-87	cyclin dependent kinase 5	Homo sapiens	59-63	
32247664-5	2020	Here, we show that cyclin-dependent kinase 5 (CDK5) plays an important role in alpha-tubulin acetylation induced by KCl depolarization or N-methyl-D-aspartate stimulation of the hippocampal slices.	N-Methylaspartate	138-158	cyclin dependent kinase 5	Homo sapiens	19-44	
16802322-1	2006	Cyclin-dependent kinase 5 (Cdk5)-p35 is downregulated in cultured neurons by N-methyl-D-aspartate (NMDA) via the proteasomal degradation of p35.	N-Methylaspartate	77-97	cyclin dependent kinase 5	Homo sapiens	0-25	
16802322-1	2006	Cyclin-dependent kinase 5 (Cdk5)-p35 is downregulated in cultured neurons by N-methyl-D-aspartate (NMDA) via the proteasomal degradation of p35.	N-Methylaspartate	77-97	cyclin dependent kinase 5	Homo sapiens	27-31	
16802322-1	2006	Cyclin-dependent kinase 5 (Cdk5)-p35 is downregulated in cultured neurons by N-methyl-D-aspartate (NMDA) via the proteasomal degradation of p35.	N-Methylaspartate	99-103	cyclin dependent kinase 5	Homo sapiens	0-25	
16802322-1	2006	Cyclin-dependent kinase 5 (Cdk5)-p35 is downregulated in cultured neurons by N-methyl-D-aspartate (NMDA) via the proteasomal degradation of p35.	N-Methylaspartate	99-103	cyclin dependent kinase 5	Homo sapiens	27-31	
16802322-3	2006	We show the enrichment of Cdk5 and p35 in the postsynaptic density and the NMDA-induced degradation of postsynaptic p35 using brain slices and cultured neurons.	N-Methylaspartate	75-79	cyclin dependent kinase 5	Homo sapiens	26-30	
32247664-5	2020	Here, we show that cyclin-dependent kinase 5 (CDK5) plays an important role in alpha-tubulin acetylation induced by KCl depolarization or N-methyl-D-aspartate stimulation of the hippocampal slices.	N-Methylaspartate	138-158	cyclin dependent kinase 5	Homo sapiens	46-50	
30709918-6	2019	Furthermore, our data indicate that tPA-induced p35-mediated Cdk5 activation does not induce cell death, but instead prevents NMDA-induced ubiquitylation of postsynaptic density protein-95 (PSD-95; also known as Dlg4) and the removal of GluR1 (also known as Gria1)-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptors from the PSD.	N-Methylaspartate	126-130	cyclin dependent kinase 5	Homo sapiens	61-65	
26002103-0	2015	CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death.	N-Methylaspartate	61-65	cyclin dependent kinase 5	Homo sapiens	0-4	
26002103-1	2015	Defects in mitochondrial fission and cyclin dependent kinase 5 (CDK5) activation are early events that precede neuronal loss following NMDA-induced neuronal death.	N-Methylaspartate	135-139	cyclin dependent kinase 5	Homo sapiens	37-62	
26002103-1	2015	Defects in mitochondrial fission and cyclin dependent kinase 5 (CDK5) activation are early events that precede neuronal loss following NMDA-induced neuronal death.	N-Methylaspartate	135-139	cyclin dependent kinase 5	Homo sapiens	64-68	
26002103-2	2015	Here, we report that the cytoplasmic CDK5 tightly regulates mitochondrial morphology defects associated with NMDA-induced neuronal injury via regulation of the mitochondrial fission protein, dynamin-related protein 1 (DRP1).	N-Methylaspartate	109-113	cyclin dependent kinase 5	Homo sapiens	37-41	
26002103-7	2015	In addition, pharmacological inhibition of CDK5 by Roscovitine inhibits DRP1 phosphorylation and mitochondrial fission associated with NMDA-induced neuronal loss.	N-Methylaspartate	135-139	cyclin dependent kinase 5	Homo sapiens	43-47	
26002103-8	2015	Importantly, conditional deletion of CDK5 significantly attenuates DRP1 phosphorylation at S585 and rescues mitochondrial fission defects in neurons exposed to NMDA.	N-Methylaspartate	160-164	cyclin dependent kinase 5	Homo sapiens	37-41