PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28087150-0 2017 Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-alpha expression in mice. N-Methylaspartate 24-28 mitogen-activated protein kinase 3 Mus musculus 102-108 28057557-7 2017 The anesthetic-induced depression of ERK1 phosphorylation was blocked by 1 mMN-methyl-d-aspartate (NMDA). N-Methylaspartate 99-103 mitogen-activated protein kinase 3 Mus musculus 37-41 18855935-6 2009 Furthermore, SEA0400 reduced the number of TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling)-positive cells and the expression of phosphorylated mitogen-activated protein kinases (ERK1/2, JNK, p38) induced by NMDA injection. N-Methylaspartate 228-232 mitogen-activated protein kinase 3 Mus musculus 199-205 26655082-12 2016 The NMDA-induced alterations in ERK1/2 phosphorylation and occludin levels were reversed by pretreatment with PD98059, a MEK inhibitor, and MK-801, a NMDAR antagonist, respectively. N-Methylaspartate 4-8 mitogen-activated protein kinase 3 Mus musculus 32-38 26655082-10 2016 As to the mechanism, NMDA stimulated sequential phosphorylations of extracellular signal-regulated kinase (ERK)1/2 and mitogen-activated ERK (MEK)1. N-Methylaspartate 21-25 mitogen-activated protein kinase 3 Mus musculus 68-114 23387889-2 2012 Short-term incubation (15 min) of cerebellar neurons with homocysteine (HC) or N-methyl-D-aspartate (NMDA) induced partial ERK 1/2 phosphorylation thus providing the activation of the enzyme. N-Methylaspartate 79-99 mitogen-activated protein kinase 3 Mus musculus 123-130 23387889-2 2012 Short-term incubation (15 min) of cerebellar neurons with homocysteine (HC) or N-methyl-D-aspartate (NMDA) induced partial ERK 1/2 phosphorylation thus providing the activation of the enzyme. N-Methylaspartate 101-105 mitogen-activated protein kinase 3 Mus musculus 123-130 21056589-8 2011 This increased excitotoxicity in SOD1(G93A) near-pure neuronal cultures appears to be mediated by a significant increase in NMDA-dependent rises of intraneuronal Ca2+ levels as well as enhanced production of cytosolic reactive oxygen species, while the injurious process seems to be unrelated to activation of nNOS or ERK1/2 pathways. N-Methylaspartate 124-128 mitogen-activated protein kinase 3 Mus musculus 318-324 19317851-4 2009 We used immunoblotting and immunohistochemistry techniques to detect NMDA-stimulated ERK1/2 activation in acute hippocampal slices prepared from adult fetal alcohol-exposed mice. N-Methylaspartate 69-73 mitogen-activated protein kinase 3 Mus musculus 85-91 17722069-0 2008 ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury. N-Methylaspartate 46-66 mitogen-activated protein kinase 3 Mus musculus 0-4 17722069-4 2008 Here we describe a previously unknown role for retinal glial cells in NMDA-induced retinal injury that involves the activation of ERK1/2. N-Methylaspartate 70-74 mitogen-activated protein kinase 3 Mus musculus 130-136 17722069-5 2008 Within 1 hr after injecting NMDA intravitreally, activation of ERK1/2 and c-Fos induction were observed in retinal Muller cells. N-Methylaspartate 28-32 mitogen-activated protein kinase 3 Mus musculus 63-69 17722069-7 2008 NMDA-induced ERK1/2 activation in retina was significantly suppressed in ERK1(-/-) mice, and these mice had significantly higher numbers of TUNEL-positive retinal cells than wild-type mice 24 hr after NMDA injection. N-Methylaspartate 0-4 mitogen-activated protein kinase 3 Mus musculus 13-19 17722069-7 2008 NMDA-induced ERK1/2 activation in retina was significantly suppressed in ERK1(-/-) mice, and these mice had significantly higher numbers of TUNEL-positive retinal cells than wild-type mice 24 hr after NMDA injection. N-Methylaspartate 0-4 mitogen-activated protein kinase 3 Mus musculus 13-17 30337665-2 2018 ERK1/2 activation by L-DOPA takes place through the crosstalk between D1R/AC/PKA/DARPP-32 pathway and NMDA/Ras pathway. N-Methylaspartate 102-106 mitogen-activated protein kinase 3 Mus musculus 0-6 16237173-5 2005 The phosphorylation states of NR2B and ERK1/2 were reduced in the dentate gyrus of hAPP mice, suggesting attenuated activity in NMDA-dependent signaling pathways that regulate synaptic plasticity as well as Arc expression. N-Methylaspartate 128-132 mitogen-activated protein kinase 3 Mus musculus 39-45 15447679-4 2004 Similarly, brief treatment of hippocampal slices with NMDA resulted in activation of Mnk1 and increased phosphorylation of eIF4E. N-Methylaspartate 54-58 mitogen-activated protein kinase 3 Mus musculus 85-89 15447679-5 2004 The NMDA-induced activation of Mnk1 and increased phosphorylation of eIF4E were dependent on PKA and ERK, but not PKC, and were present in synaptoneurosome preparations. N-Methylaspartate 4-8 mitogen-activated protein kinase 3 Mus musculus 31-35 15447679-6 2004 Immunohistochemical analysis revealed that the PKA- and ERK-dependent increases in Mnk1 activation induced by NMDA also occurred in dendrites. N-Methylaspartate 110-114 mitogen-activated protein kinase 3 Mus musculus 83-87 29679291-5 2018 The present study aimed to evaluate the effect of NMDA preconditioning on PI3K/Akt, ERK1/2, and p38MAPK pathways in the hippocampus of mice and characterize the involvement of PI3K on NMDA preconditioning-evoked prevention of seizures and hippocampal cell damage induced by quinolinic acid (QA). N-Methylaspartate 50-54 mitogen-activated protein kinase 3 Mus musculus 84-90