PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30347737-0	2018	Hesperidin Prevents Nitric Oxide Deficiency-Induced Cardiovascular Remodeling in Rats via Suppressing TGF-beta1 and MMPs Protein Expression.	Hesperidin	0-10	transforming growth factor, beta 1	Rattus norvegicus	102-111	
31611754-9	2019	Hesperidin significantly inhibited BLM-induced down-regulated lung Nrf2 and HO-1 as well as up-regulated TNF-alpha, IL-1beta, IL-6, collagen-1, TGF-beta, and Smad-3 mRNA expressions.	Hesperidin	0-10	transforming growth factor, beta 1	Rattus norvegicus	144-152	
31611754-12	2019	Hesperidin alleviates BLM-induced IPF via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB pathways which in turn ameliorate the modulation of oxido-inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-alpha, IL-1beta, and IL-6) to reduce collagen deposition during pulmonary fibrosis.	Hesperidin	0-10	transforming growth factor, beta 1	Rattus norvegicus	56-65	
31611754-0	2019	Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB pathways.	Hesperidin	0-10	transforming growth factor, beta 1	Rattus norvegicus	91-100	
31298400-8	2019	RESULTS: 5/10 mg/L Berberine intervention could noticeably decrease both TGF-beta1 and IL-1beta levels, 25/50/100 micromol/L Hesperidin could reduce IL-1beta secretion from TGF-beta1 stimulated cardiac fibroblasts.	Hesperidin	125-135	transforming growth factor, beta 1	Rattus norvegicus	173-182	
31298400-12	2019	CONCLUSIONS: Berberine and Hesperidin can reduce the secretion of inflammatory cytokines, differentiation, and proliferation, and increase the collagen synthesis of cardiac fibroblasts stimulated by TGF-beta1 via the Notch1 signaling pathway.	Hesperidin	27-37	transforming growth factor, beta 1	Rattus norvegicus	199-208	
33185907-0	2021	Hesperidin inhibits L-NAME-induced vascular and renal alterations in rats by suppressing the renin-angiotensin system, transforming growth factor-beta1, and oxidative stress.	Hesperidin	0-10	transforming growth factor, beta 1	Rattus norvegicus	119-151	
28935427-0	2017	Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARgamma and TGF-beta1/Smad3 signaling, and amelioration of oxidative stress and inflammation.	Hesperidin	0-10	transforming growth factor, beta 1	Rattus norvegicus	115-124	
28935427-3	2017	We demonstrated the modulatory effect of hesperidin on Nrf2/ARE/HO-1, PPARgamma and TGF-beta1/Smad3 signaling.	Hesperidin	41-51	transforming growth factor, beta 1	Rattus norvegicus	84-93	
28935427-9	2017	Hesperidin dramatically abolished NF-kappaB and TGF-beta1/Smad3 signaling as well as collagen deposition in the liver of DEN/CCl4-induced rats.	Hesperidin	0-10	transforming growth factor, beta 1	Rattus norvegicus	48-57	
28935427-11	2017	In conclusion, hesperidin can inhibit hepatocarcinogenesis by suppressing oxidative stress, inflammation, cell proliferation, TGF-beta1/Smad3 signaling and collagen deposition.	Hesperidin	15-25	transforming growth factor, beta 1	Rattus norvegicus	126-135	
26697692-0	2015	Effect of hesperidin on TGF-beta1/Smad signaling pathway in HSC.	Hesperidin	10-20	transforming growth factor, beta 1	Rattus norvegicus	24-33	
33185907-4	2021	The preventive treatment with hesperidin and captopril also significantly decreased serum angiotensin-converting enzyme activity and plasma transforming growth factor-beta1 (TGF-beta1) levels and downregulated angiotensin II receptor type Iand TGF-beta1 protein expression in the kidneys.	Hesperidin	30-40	transforming growth factor, beta 1	Rattus norvegicus	140-172	
33185907-4	2021	The preventive treatment with hesperidin and captopril also significantly decreased serum angiotensin-converting enzyme activity and plasma transforming growth factor-beta1 (TGF-beta1) levels and downregulated angiotensin II receptor type Iand TGF-beta1 protein expression in the kidneys.	Hesperidin	30-40	transforming growth factor, beta 1	Rattus norvegicus	174-183	
33185907-4	2021	The preventive treatment with hesperidin and captopril also significantly decreased serum angiotensin-converting enzyme activity and plasma transforming growth factor-beta1 (TGF-beta1) levels and downregulated angiotensin II receptor type Iand TGF-beta1 protein expression in the kidneys.	Hesperidin	30-40	transforming growth factor, beta 1	Rattus norvegicus	244-253