PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18387509-9	2008	Taken together, hesperidin, hesperidin methyl chalone and phellopterin reduce TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.	Hesperidin	16-26	tumor necrosis factor	Homo sapiens	78-87	
31844967-7	2020	RESULTS: Compared with the placebo group, hesperidin decreased fasting glucose level (- 6.07 vs. - 13.32 mg/dL, P = 0.043), triglyceride (- 8.83 vs. - 49.09 mg/dL, P = 0.049), systolic blood pressure (- 0.58 vs. - 2.68 mmHg, P = 0.048) and TNF-alpha (- 1.29 vs. - 4.44 pg/mL, P = 0.009).	Hesperidin	42-52	tumor necrosis factor	Homo sapiens	240-249	
31844967-8	2020	Based on the within-group analysis, hesperidin led to significant decrease in serum levels of glucose, insulin, triglyceride, total cholesterol, low density lipoprotein cholesterol, TNF-alpha and hs-CRP, while in control group only glucose and insulin significantly decreased.	Hesperidin	36-46	tumor necrosis factor	Homo sapiens	182-191	
31929574-8	2020	Similarly, hesperidin also improved the serum and tissue levels of leptin, interleukin-6 and tumor necrosis factor-alpha more significantly (P<0.05) when compared with that of orlistat.	Hesperidin	11-21	tumor necrosis factor	Homo sapiens	93-120	
30817082-10	2019	In Caco-2 cells, it is shown that hesperidin prevents TNF-alpha/IFN-gamma-induced reduction in TEER and morphological disruption.	Hesperidin	34-44	tumor necrosis factor	Homo sapiens	54-63	
31074547-6	2019	Our results demonstrated that HES decreased the levels of TNF-alpha and IL-6, attenuated the glucose content in culture medium and increased glucose uptake in insulin-resistant HepG2 cells in vitro.	Hesperidin	30-33	tumor necrosis factor	Homo sapiens	58-67	
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	Hesperidin	95-105	tumor necrosis factor	Homo sapiens	157-166	
17400256-8	2007	In vitro, HES suppressed the expression of IL-8 on A549 cells and THP-1 cells, the expression of TNF-alpha, IL-1 beta, and IL-6 on THP-1 cells, the expression of ICAM-1 and VCAM-1 on A549 cells which effect cell adhesion function.	Hesperidin	10-13	tumor necrosis factor	Homo sapiens	97-106	
17400256-10	2007	HES inhibits those pathways, thereby suppressing the expression of IL-8, TNFalpha, IL-1 beta, IL-6, IL-12, ICAM-1 and VCAM-1.	Hesperidin	0-3	tumor necrosis factor	Homo sapiens	73-81