PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25859982-7	2015	Moreover, elevated TNF-alpha and IL-1beta levels, a result of EAE, were decreased in serum and neurological deficits as clinical signs were reversed with HP treatment in EAE mice, given HP.	Hesperidin	154-156	tumor necrosis factor	Mus musculus	19-28	
34956584-10	2021	After treatment with hesperidin, BV2 cells induced by MCAO in vitro can reduce the proinflammatory cytokines of TNF-alpha and IL-1beta significantly, further upregulating anti-inflammatory cytokines of TGF-beta, IL-10 while inhibiting TLR4 and p-NF-kappaB expression.	Hesperidin	21-31	tumor necrosis factor	Mus musculus	112-121	
34721041-11	2021	Results: Compared with the ATO group, the HES treatment groups reduced the levels of CK, LDH, cTnI, ROS, MDA, TNF-alpha, IL-6, Bax, Caspase-3, cleaved-Caspase-3 and Keap1 and enhanced the levels of SOD, GSH, CAT, Bcl-2, p62 and Nrf2.	Hesperidin	42-45	tumor necrosis factor	Mus musculus	110-119	
35332348-10	2022	HES also reduced the CP-induced release of the inflammatory factors tumour necrosis factor (TNF)-alpha and interleukin (IL)-6.	Hesperidin	0-3	tumor necrosis factor	Mus musculus	68-102	
30352242-9	2018	In addition, hesperidin decreased the levels of IL-1beta, TNF-alpha and MDA, and increased BDNF levels in the hippocampus.	Hesperidin	13-23	tumor necrosis factor	Mus musculus	58-67	
15133244-1	2004	Administration of a citrus flavonoid hesperidin (HES) to mice before LPS challenge significantly reduced tumor necrosis factor (TNF)-alpha production in a dose-dependent manner.	Hesperidin	49-52	tumor necrosis factor	Mus musculus	105-138	
29115547-7	2018	Hesperidin treatment caused a significant decrease in the levels of TNF-alpha, IL-1beta, IL-6, MCP-1, ICAM-1, MDA, CAT, SOD and caspase-3/9 in mice with AMI.	Hesperidin	0-10	tumor necrosis factor	Mus musculus	68-77	
25859982-7	2015	Moreover, elevated TNF-alpha and IL-1beta levels, a result of EAE, were decreased in serum and neurological deficits as clinical signs were reversed with HP treatment in EAE mice, given HP.	Hesperidin	186-188	tumor necrosis factor	Mus musculus	19-28