PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30066841-0	2018	Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury.	Hesperidin	97-107	AKT serine/threonine kinase 1	Homo sapiens	47-50	
31936263-7	2020	In summary, hesperidin inhibits breast cancer cell growth through the inhibition of the expression of PD-L1 via downregulation of Akt and NF-kappaB signaling in TNBC.	Hesperidin	12-22	AKT serine/threonine kinase 1	Homo sapiens	130-133	
33926520-7	2021	RESULTS: Compared to the NG treatment, hesperidin treatment increased the viability and improved the oxidative stress, mitochondrial dysfunction and insulin resistance of HG-treated LO2 cells, and these effects were correlated with heightened SOD and GPx activities, increased MMP level and ATP generation, reduced MDA, ROS and glucose levels, and activated GSK3beta/AKT and inactivated IRS1 signals.	Hesperidin	39-49	AKT serine/threonine kinase 1	Homo sapiens	367-370	
31936263-5	2020	Additionally, high expression of PD-L1 (both mRNA and protein) in aggressive cancer cells was strongly inhibited by hesperidin through inhibition of Akt and NF-kappaB signaling.	Hesperidin	116-126	AKT serine/threonine kinase 1	Homo sapiens	149-152	
30066841-2	2018	The present study aimed to investigate whether hesperidin inhibited I/R-induced excessive myocardial autophagy through activating the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway.	Hesperidin	47-57	AKT serine/threonine kinase 1	Homo sapiens	189-192	
30066841-7	2018	Furthermore, the expression levels of LC3II and Beclin1 were significantly downregulated and the expression levels of p-mTOR, p-Akt and p-PI3K were markedly upregulated by hesperidin.	Hesperidin	172-182	AKT serine/threonine kinase 1	Homo sapiens	128-131	
30066841-10	2018	Activation of the PI3K/Akt/mTOR pathway contributed to the inhibitory effect of hesperidin on excessive autophagy.	Hesperidin	80-90	AKT serine/threonine kinase 1	Homo sapiens	23-26	
29893306-0	2018	Hesperidin inhibits insulin-induced phosphoinositide 3-kinase/Akt activation in human pre-B cell line NALM-6.	Hesperidin	0-10	AKT serine/threonine kinase 1	Homo sapiens	62-65	
29893306-2	2018	Aims: To investigate the effect of hesperidin on inhibition of NF-kappaB activation through blocking phosphoinositide 3-kinase (PI3K)/Akt pathway as a main target in cancer treatment, in NALM-6 cells.	Hesperidin	35-45	AKT serine/threonine kinase 1	Homo sapiens	134-137	
29893306-3	2018	Materials and Methods: NALM-6 cells were incubated with two concentrations of hesperidin (25, 50 muM) in the presence or absence of insulin (100 nM), as a potent activator of Akt.	Hesperidin	78-88	AKT serine/threonine kinase 1	Homo sapiens	175-178	
29893306-9	2018	Hesperidin inhibited insulin-induced phosphorylation and activation of Akt, IkappaBalpha, and GSK-3beta and decreased expression of IKKalpha.	Hesperidin	0-10	AKT serine/threonine kinase 1	Homo sapiens	71-74	
29893306-10	2018	Conclusion: The results of this study demonstrated that cytotoxic and proapoptotic actions of hesperidin are partly mediated through the suppression of PI3K3/Akt/IKK signaling pathway.	Hesperidin	94-104	AKT serine/threonine kinase 1	Homo sapiens	158-161	
25767683-8	2015	The results from this study suggest that YE, hesperidin and naringin can inhibit human platelet aggregation, at least partly through the inhibition of PLCgamma and Akt, leading to a decrease in TXB2 formation and granule secretion.	Hesperidin	45-55	AKT serine/threonine kinase 1	Homo sapiens	164-167	
25047426-0	2014	Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis.	Hesperidin	0-10	AKT serine/threonine kinase 1	Homo sapiens	127-130	
25047426-4	2014	In the present study, we aimed at investigating the potential of hesperidin over the abrogated Aurora-A coupled pro-survival phosphoinositide-3-kinase (PI3K)/Akt signalling cascades.	Hesperidin	65-75	AKT serine/threonine kinase 1	Homo sapiens	158-161	
25047426-10	2014	Hesperidin treatment caused significant up-regulation of tumour suppressor phosphatase and tensin homologue (PTEN) with a reduction in the expression of AOM mediated p-PI3K and p-Akt.	Hesperidin	0-10	AKT serine/threonine kinase 1	Homo sapiens	179-182	
25047426-12	2014	Aurora-A an upstream regulator of PI3K/Akt pathway was significantly inhibited by hesperidin.	Hesperidin	82-92	AKT serine/threonine kinase 1	Homo sapiens	39-42	
25047426-14	2014	Taken together, hesperidin supplementation initiated apoptosis via targeted inhibition of constitutively activated Aurora-A mediated PI3K/Akt/GSK-3beta and mTOR pathways coupled with autophagic stimulation against AOM induced colon carcinogenesis.	Hesperidin	16-26	AKT serine/threonine kinase 1	Homo sapiens	138-141