PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34866972-9	2021	These chemotherapeutic and chemosensitising activities of hesperidin and hesperetin have been linked to several mechanisms, including the modulation of signalling pathways, glucose uptake, enzymes, miRNA expression, oxidative status, cell cycle regulatory proteins, tumour suppressor p53, plasma and liver lipid profiles as well as DNA repair mechanisms.	Hesperidin	58-68	tumor protein p53	Homo sapiens	284-287	
35478958-0	2022	Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53.	Hesperidin	0-10	tumor protein p53	Homo sapiens	72-75	
35478958-7	2022	Our in vitro results showed that hesperidin partially reversed dexamethasone-induced inhibition of osteogenic differentiation by suppressing the activation of p53, and suggest that hesperidin may be a promising candidate for the treatment against dexamethasone-induced osteoporosis.	Hesperidin	33-43	tumor protein p53	Homo sapiens	159-162	
35478958-7	2022	Our in vitro results showed that hesperidin partially reversed dexamethasone-induced inhibition of osteogenic differentiation by suppressing the activation of p53, and suggest that hesperidin may be a promising candidate for the treatment against dexamethasone-induced osteoporosis.	Hesperidin	181-191	tumor protein p53	Homo sapiens	159-162	
33360419-10	2021	In addition, HES treatment reduced the mRNA level of p21 but increased the mRNA level of cyclin D1 and p53 in the mammosphere.	Hesperidin	13-16	tumor protein p53	Homo sapiens	103-106	
33360419-12	2021	More importantly, this study highlighted p53 as a key protein in inhibition of BCSCs by HES.	Hesperidin	88-91	tumor protein p53	Homo sapiens	41-44	
21445621-0	2012	The citrus flavonoid hesperidin induces p53 and inhibits NF-kappaB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARgamma-dependent mechanism.	Hesperidin	21-31	tumor protein p53	Homo sapiens	40-43	
21445621-8	2012	RESULTS: Hesperidin induced the expression and transcriptional activity of PPARgamma and promoted p53 accumulation and downregulated constitutive NF-kappaB activity in a PPARgamma-dependent and PPARgamma-independent manner.	Hesperidin	9-19	tumor protein p53	Homo sapiens	98-101	
25047426-9	2014	In addition, hesperidin enhanced p53-p21 axis with concomitant decrease in cell cycle regulator.	Hesperidin	13-23	tumor protein p53	Homo sapiens	33-36