PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12969786-5	2003	Our data indicate hesperidin as a COX-2 and iNOS inhibitor, which might be related to the anti-inflammatory and anti-tumorigenic efficacies.	Hesperidin	18-28	prostaglandin-endoperoxide synthase 2	Mus musculus	34-39	
12969786-2	2003	We designed to investigate the inhibitory effect of hesperidin on lipopolysaccharide (LPS)-induced over-expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) proteins, over-production of prostaglandin E2 (PGE2) and nitric oxide (NO) using mouse macrophage cells.	Hesperidin	52-62	prostaglandin-endoperoxide synthase 2	Mus musculus	118-134	
12969786-2	2003	We designed to investigate the inhibitory effect of hesperidin on lipopolysaccharide (LPS)-induced over-expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) proteins, over-production of prostaglandin E2 (PGE2) and nitric oxide (NO) using mouse macrophage cells.	Hesperidin	52-62	prostaglandin-endoperoxide synthase 2	Mus musculus	136-141	
23377175-11	2013	Hesperidin treatments caused a prominent downregulation of NF-kappaB and its target molecules iNOS and COX-2, thereby combating inflammation.	Hesperidin	0-10	prostaglandin-endoperoxide synthase 2	Mus musculus	103-108	
33152433-0	2021	Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens Makino by inhibiting COX-2 expression and inflammatory cell infiltration.	Hesperidin	24-34	prostaglandin-endoperoxide synthase 2	Mus musculus	143-148	
25434716-9	2015	We also demonstrated that the flavonoid hesperidin modulates neuronal cell death by inhibiting the overexpression of inflammatory markers like nuclear factor kappaB, inducible nitric oxide synthase, cyclooxygenase-2 and glial fibrillary acidic protein positive astrocytes.	Hesperidin	40-50	prostaglandin-endoperoxide synthase 2	Mus musculus	199-215	
20883688-0	2010	Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9.	Hesperidin	21-31	prostaglandin-endoperoxide synthase 2	Mus musculus	109-114	
20883688-2	2010	The purpose of this study is to evaluate the effect of hesperidin in modulating the expressions of cyclooxygenase-2 (COX-2), mast cells (MCs) and matrix metalloproteinases (MMPs) during benzo(a)pyrene (B(a)P) induced lung carcinogenesis in mice.	Hesperidin	55-65	prostaglandin-endoperoxide synthase 2	Mus musculus	99-115	
20883688-2	2010	The purpose of this study is to evaluate the effect of hesperidin in modulating the expressions of cyclooxygenase-2 (COX-2), mast cells (MCs) and matrix metalloproteinases (MMPs) during benzo(a)pyrene (B(a)P) induced lung carcinogenesis in mice.	Hesperidin	55-65	prostaglandin-endoperoxide synthase 2	Mus musculus	117-122	
20883688-4	2010	Supplementation of hesperidin (25 mg/kg body weight) to lung cancer bearing mice attenuated MCD and downregulated the expressions of COX-2, MMP-2 and MMP-9.	Hesperidin	19-29	prostaglandin-endoperoxide synthase 2	Mus musculus	133-138	
20883688-5	2010	These observations show that hesperidin exerts its anti-carcinogenic activity against lung cancer by altering the expressions of COX-2, MMP-2 and MMP-9.	Hesperidin	29-39	prostaglandin-endoperoxide synthase 2	Mus musculus	129-134