PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12969786-5 2003 Our data indicate hesperidin as a COX-2 and iNOS inhibitor, which might be related to the anti-inflammatory and anti-tumorigenic efficacies. Hesperidin 18-28 prostaglandin-endoperoxide synthase 2 Mus musculus 34-39 12969786-2 2003 We designed to investigate the inhibitory effect of hesperidin on lipopolysaccharide (LPS)-induced over-expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) proteins, over-production of prostaglandin E2 (PGE2) and nitric oxide (NO) using mouse macrophage cells. Hesperidin 52-62 prostaglandin-endoperoxide synthase 2 Mus musculus 118-134 12969786-2 2003 We designed to investigate the inhibitory effect of hesperidin on lipopolysaccharide (LPS)-induced over-expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) proteins, over-production of prostaglandin E2 (PGE2) and nitric oxide (NO) using mouse macrophage cells. Hesperidin 52-62 prostaglandin-endoperoxide synthase 2 Mus musculus 136-141 33152433-0 2021 Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens Makino by inhibiting COX-2 expression and inflammatory cell infiltration. Hesperidin 24-34 prostaglandin-endoperoxide synthase 2 Mus musculus 143-148 25434716-9 2015 We also demonstrated that the flavonoid hesperidin modulates neuronal cell death by inhibiting the overexpression of inflammatory markers like nuclear factor kappaB, inducible nitric oxide synthase, cyclooxygenase-2 and glial fibrillary acidic protein positive astrocytes. Hesperidin 40-50 prostaglandin-endoperoxide synthase 2 Mus musculus 199-215 23377175-11 2013 Hesperidin treatments caused a prominent downregulation of NF-kappaB and its target molecules iNOS and COX-2, thereby combating inflammation. Hesperidin 0-10 prostaglandin-endoperoxide synthase 2 Mus musculus 103-108 20883688-0 2010 Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. Hesperidin 21-31 prostaglandin-endoperoxide synthase 2 Mus musculus 109-114 20883688-2 2010 The purpose of this study is to evaluate the effect of hesperidin in modulating the expressions of cyclooxygenase-2 (COX-2), mast cells (MCs) and matrix metalloproteinases (MMPs) during benzo(a)pyrene (B(a)P) induced lung carcinogenesis in mice. Hesperidin 55-65 prostaglandin-endoperoxide synthase 2 Mus musculus 99-115 20883688-2 2010 The purpose of this study is to evaluate the effect of hesperidin in modulating the expressions of cyclooxygenase-2 (COX-2), mast cells (MCs) and matrix metalloproteinases (MMPs) during benzo(a)pyrene (B(a)P) induced lung carcinogenesis in mice. Hesperidin 55-65 prostaglandin-endoperoxide synthase 2 Mus musculus 117-122 20883688-4 2010 Supplementation of hesperidin (25 mg/kg body weight) to lung cancer bearing mice attenuated MCD and downregulated the expressions of COX-2, MMP-2 and MMP-9. Hesperidin 19-29 prostaglandin-endoperoxide synthase 2 Mus musculus 133-138 20883688-5 2010 These observations show that hesperidin exerts its anti-carcinogenic activity against lung cancer by altering the expressions of COX-2, MMP-2 and MMP-9. Hesperidin 29-39 prostaglandin-endoperoxide synthase 2 Mus musculus 129-134