PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22074828-10	2011	This study demonstrated that hesperidin, naringin, and resveratrol reduced the HG-induced ICAM-1 expression via the p38 MAPK signaling pathway, contributing to the inhibition of monocyte adhesion to endothelial cells.	Hesperidin	29-39	mitogen-activated protein kinase 1	Homo sapiens	116-119	
25429875-7	2014	In addition, hesperidin restricted RNPs export from nucleus by down-regulating ERK activation, but kaempferol promoted RNPs export by up-regulating ERK activation.	Hesperidin	13-23	mitogen-activated protein kinase 1	Homo sapiens	79-82	
22074828-10	2011	This study demonstrated that hesperidin, naringin, and resveratrol reduced the HG-induced ICAM-1 expression via the p38 MAPK signaling pathway, contributing to the inhibition of monocyte adhesion to endothelial cells.	Hesperidin	29-39	mitogen-activated protein kinase 1	Homo sapiens	120-124	
18430059-9	2008	Hesperidin also inhibited strain-induced increases in the formation of reactive oxygen species and extracellular signal-regulated kinase (ERK) phosphorylation.	Hesperidin	0-10	mitogen-activated protein kinase 1	Homo sapiens	99-136	
20678535-7	2010	Western blot showed that hesperidin facilitated ERK/MAPK phosphorylation which appeared to be responsible for nuclear translocation of Nrf2, thereby inducing cytoprotective heme oxygenase-1 (HO-1) expression.	Hesperidin	25-35	mitogen-activated protein kinase 1	Homo sapiens	48-51	
20678535-7	2010	Western blot showed that hesperidin facilitated ERK/MAPK phosphorylation which appeared to be responsible for nuclear translocation of Nrf2, thereby inducing cytoprotective heme oxygenase-1 (HO-1) expression.	Hesperidin	25-35	mitogen-activated protein kinase 1	Homo sapiens	52-56	
20170153-8	2010	Taken together, the above findings suggested that hesperidin augmented cellular antioxidant defense capacity through the induction of HO-1 via ERK/Nrf2 signaling.	Hesperidin	50-60	mitogen-activated protein kinase 1	Homo sapiens	143-146	
18430059-9	2008	Hesperidin also inhibited strain-induced increases in the formation of reactive oxygen species and extracellular signal-regulated kinase (ERK) phosphorylation.	Hesperidin	0-10	mitogen-activated protein kinase 1	Homo sapiens	138-141	
18430059-12	2008	Furthermore, hesperidin modulated strain-induced ET-1 release and suppressed ERK phosphorylation in part via the NO/protein kinase G pathway.	Hesperidin	13-23	mitogen-activated protein kinase 1	Homo sapiens	77-80