PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33972147-0	2022	NF-kappaB and COX-2 repression with topical application of hesperidin and naringin hydrogels augments repair and regeneration of deep dermal wounds.	Hesperidin	59-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9	
33972147-10	2022	The hesperidin/naringin hydrogel suppressed NF-kappaB and COX-2 expression on days 6 and 12.	Hesperidin	4-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53	
33972147-11	2022	CONCLUSIONS: Application of 5% hesperidin hydrogel was more effective than 5% naringin or combination of hesperidin and naringin gels (1:1, 2:1 or 1:2) indicated by a greater wound contraction, reduced mean wound healing time, elevated collagen and DNA syntheses, rise in glutathione concentration, and superoxide dismutase activity followed by reduced lipid peroxidation, and NF-kappaB, and COX-2 expression.	Hesperidin	31-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	377-386	
30928632-9	2019	In conclusion, hesperidin possessed efficient neuroprotective effects on depression, which was associated with neuroinflammation mediated by the HMGB1/RAGE/NF-kappaB and BDNF/TrkB pathways.	Hesperidin	15-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	156-165	
34956584-10	2021	After treatment with hesperidin, BV2 cells induced by MCAO in vitro can reduce the proinflammatory cytokines of TNF-alpha and IL-1beta significantly, further upregulating anti-inflammatory cytokines of TGF-beta, IL-10 while inhibiting TLR4 and p-NF-kappaB expression.	Hesperidin	21-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	246-255	
34956584-13	2021	In vitro experiments further verified that hesperidin plays a neuroprotective role by inhibiting the TLR4-NF-kappaB pathway, thus providing new targets and strategies for neuroprotection and nerve repair after ischemic stroke.	Hesperidin	43-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-115	
26391026-0	2018	Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-kappaB signaling.	Hesperidin	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-140	
23377175-11	2013	Hesperidin treatments caused a prominent downregulation of NF-kappaB and its target molecules iNOS and COX-2, thereby combating inflammation.	Hesperidin	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-68