PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34743946-4	2021	The data obtained show that PTX-induced MDA, NF-kappaB, IL-1beta, TNF-alpha, COX-2, nNOS, JAK2, STAT3, and GFAP levels decreased with HES administration.	Hesperidin	134-137	interleukin 1 alpha	Rattus norvegicus	56-64	
33216334-7	2020	Biochemical analyses revealed that hesperidin showed anti-inflammatory effects by decreasing IL-1beta and TNF-alpha levels at the 24th h as well as strong antioxidant activity by increasing TAS levels in groups III and IV.	Hesperidin	35-45	interleukin 1 alpha	Rattus norvegicus	93-101	
27427274-8	2016	There was also down-regulation of the expression of gene for interleukin 1alpha, interleukin 1beta, interleukin 1 receptor, interleukin 6, and tumor necrosis factor alpha (TNFalpha) in the liver of rats treated with LPS as a result of hesperidin pretreatment.	Hesperidin	235-245	interleukin 1 alpha	Rattus norvegicus	61-79	
32922291-9	2020	In addition, hesperidin decreased the expression levels of IL-1beta, IL-6, TNF-alpha, NLRP3, caspase-1, and ASC in the PFC and microglia.	Hesperidin	13-23	interleukin 1 alpha	Rattus norvegicus	59-67	
34028927-14	2021	Hesperidin significantly diminishes the cytokine levels, such as tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-1beta, and inflammatory mediators such as nuclear factor-kappa B.	Hesperidin	0-10	interleukin 1 alpha	Rattus norvegicus	120-128