PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30658103-0	2019	Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway.	Hesperidin	0-10	mitogen-activated protein kinase 3	Homo sapiens	109-115	
20170153-6	2010	What"s more, hesperidin exhibited activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2).	Hesperidin	13-23	mitogen-activated protein kinase 3	Homo sapiens	99-105	
20170153-7	2010	Besides, ERK1/2 inhibitor significantly inhibited hesperidin-mediated HO-1 upregulation and Nrf2 nuclear translocation.	Hesperidin	50-60	mitogen-activated protein kinase 3	Homo sapiens	9-15	
24977707-0	2014	hesperidin induces paraptosis like cell death in hepatoblastoma, HepG2 Cells: involvement of ERK1/2 MAPK [corrected].	Hesperidin	0-10	mitogen-activated protein kinase 3	Homo sapiens	93-99	
24977707-6	2014	It was observed that hesperidin induced cell death is nonautophagic and also activate mitogen activated protein kinase ERK1/2.	Hesperidin	21-31	mitogen-activated protein kinase 3	Homo sapiens	119-125	
24977707-7	2014	Taken together, the data indicate that hesperidin induces paraptosis like cell death in HepG2 cells with the activation of ERK1/2.	Hesperidin	39-49	mitogen-activated protein kinase 3	Homo sapiens	123-129	
26262610-0	2015	Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation.	Hesperidin	0-10	mitogen-activated protein kinase 3	Homo sapiens	61-67	
26262610-8	2015	Hesperidin decreased tyrosinase, TRP-1, and TRP-2 protein expression but increased phospho-extracellular signal-regulated kinase 1/2 (p-Erk1/2) expression.	Hesperidin	0-10	mitogen-activated protein kinase 3	Homo sapiens	136-142	
26262610-9	2015	Specific inhibitor of Erk1/2 or proteasome inhibitor reversed the inhibition of melanogenesis induced by hesperidin.	Hesperidin	105-115	mitogen-activated protein kinase 3	Homo sapiens	22-28	
26262610-10	2015	Taken together, hesperidin, a popular antioxidant, stimulated Erk1/2 phosphorylation which subsequently degraded MITF which resulted in suppression of melanogenic enzymes and melanin synthesis.	Hesperidin	16-26	mitogen-activated protein kinase 3	Homo sapiens	62-68