PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31412747-11	2021	In animals treated with hesperidin 100 mg/kg, Akt protein expression was increased, while the BAX/BCL2 ratio was significantly decreased.	Hesperidin	24-34	AKT serine/threonine kinase 1	Rattus norvegicus	46-49	
32462317-0	2021	Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome.	Hesperidin	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	87-90	
32462317-10	2021	Restoration of the insulin signaling pathway, IRS/Akt/GLUT4 protein expression, was demonstrated in hesperidin and metformin-treated groups (p < 0.05).	Hesperidin	100-110	AKT serine/threonine kinase 1	Rattus norvegicus	50-53	
35413380-9	2022	Hesperidin also reduced the adverse effects caused by NaF by modulating the PI3K/Akt/mTOR signaling pathway.	Hesperidin	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	81-84	
32296010-0	2020	The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor-kappaB (NF-kappaB) Signaling Pathways.	Hesperidin	15-25	AKT serine/threonine kinase 1	Rattus norvegicus	138-141	
30779474-0	2019	Involvement of PI3K/Akt pathway in the protective effect of hesperidin against a chemically induced liver cancer in rats.	Hesperidin	60-70	AKT serine/threonine kinase 1	Rattus norvegicus	20-23	
30779474-2	2019	This study investigated the effect of hesperidin on the PI3K/Akt pathway as a possible mechanism for its protective effect against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC).	Hesperidin	38-48	AKT serine/threonine kinase 1	Rattus norvegicus	61-64	
30779474-5	2019	Moreover, hesperidin administration suppressed DEN-induced upregulation of PI3K, Akt, CDK-2 protein expression, and preserved the integrity of the liver tissues from HCC formation.	Hesperidin	10-20	AKT serine/threonine kinase 1	Rattus norvegicus	81-84	
30779474-6	2019	In conclusion, the hepatoprotective activity of hesperidin is mediated via its antioxidation and downregulation of the PI3K/Akt pathway.	Hesperidin	48-58	AKT serine/threonine kinase 1	Rattus norvegicus	124-127	
27744432-0	2016	Short-Term Hesperidin Pretreatment Attenuates Rat Myocardial Ischemia/Reperfusion Injury by Inhibiting High Mobility Group Box 1 Protein Expression via the PI3K/Akt Pathway.	Hesperidin	11-21	AKT serine/threonine kinase 1	Rattus norvegicus	161-164	
27744432-2	2016	This study aimed to investigate the cardioprotective effects of a 3-day hesperidin pretreatment on I/R injury and to further explore whether its mechanism of action was associated with the inhibition of high mobility group box 1 protein (HMGB1) expression via the PI3K/Akt pathway.	Hesperidin	72-82	AKT serine/threonine kinase 1	Rattus norvegicus	269-272	
27744432-7	2016	Additionally, hesperidin downregulated HMGB1 expression and upregulated p-Akt expression in the myocardium.	Hesperidin	14-24	AKT serine/threonine kinase 1	Rattus norvegicus	74-77	
27744432-8	2016	LY294002, a specific PI3K inhibitor, partially reversed the decreased HMGB1 expression, increased p-Akt expression induced by hesperidin and abolished the anti-apoptotic, anti-inflammatory and anti-oxidative effects of hesperidin.	Hesperidin	126-136	AKT serine/threonine kinase 1	Rattus norvegicus	100-103	
27744432-9	2016	CONCLUSION: These findings suggest that short-term pretreatment with hesperidin protects against myocardial I/R injury by suppressing myocardial apoptosis, the inflammatory response and oxidative stress via PI3K/Akt pathway activation and HMGB1 inhibition.	Hesperidin	69-79	AKT serine/threonine kinase 1	Rattus norvegicus	212-215	
29687202-0	2018	Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3beta Pathway by Hesperidin in Wistar Rats.	Hesperidin	119-129	AKT serine/threonine kinase 1	Rattus norvegicus	94-97	
24076349-8	2013	Hesperidin treatment also activated a key survival signaling kinase, Akt, and suppressed the P-FoxO3 level.	Hesperidin	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	69-72	
24076349-9	2013	Hesperidin pretreatment protected neonatal HIE by reducing free radicals and activating phosphorylated Akt.	Hesperidin	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	103-106