PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35413380-8	2022	Moreover, hesperidin was able to down-regulate the mRNA transcript levels of apoptosis and endoplasmic reticulum stress markers such as caspase-3, Bax, Bcl-2, PERK, IRE1, ATF6, and GRP78 in NaF-induced neurotoxicity.	Hesperidin	10-20	caspase 3	Rattus norvegicus	136-145	
34743946-7	2021	HES, on the other hand, showed an anti-apoptotic effect, increasing Bcl-2 levels and decreasing Caspase-3 and Bax levels.	Hesperidin	0-3	caspase 3	Rattus norvegicus	96-105	
34422219-3	2021	The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions.	Hesperidin	36-46	caspase 3	Rattus norvegicus	251-260	
35566151-10	2022	TME and hesperidin distinctly diminished the mRNA and protein expression of NF-kappaB, cleaved caspase-3, and BAX, and increased BCL2 expression (reflecting its protective and antiapoptotic actions).	Hesperidin	8-18	caspase 3	Rattus norvegicus	95-104	
31753617-10	2020	Marked reductions in caspase-3 were also observed following HES-SLN treatment.	Hesperidin	60-63	caspase 3	Rattus norvegicus	21-30	
33216334-9	2020	Immunohistochemically, hesperidin reduced the number of caspase 3-positive apoptotic cells in groups III and IV.	Hesperidin	23-33	caspase 3	Rattus norvegicus	56-65	
31505195-7	2019	Furthermore, hesperidin effectively modulated expressions of apoptosis-regulatory proteins in diabetic rat pancreas, as revealed by upregulating anti-apoptotic Bcl-xL; with a concomitant downregulating pro-apoptotic Bax, cleaved caspase-3, and inhibiting the activation of DNA repair protein poly (ADP-ribose) polymerase (PARP).	Hesperidin	13-23	caspase 3	Rattus norvegicus	229-238	
26551080-9	2015	Hesperidin was found to induce caspase-3, caspase-9, bax expression and downregulate bcl-2, NFkappaB, iNOS, TNF-alpha, PCNA expression.	Hesperidin	0-10	caspase 3	Rattus norvegicus	31-40	
27279838-10	2016	In contrast, HP treatment eliminated the effects of CCl4 and stimulated anti-apoptotic events, as characterized by reduced caspase-3 activation.	Hesperidin	13-15	caspase 3	Rattus norvegicus	123-132	
30557884-10	2018	Hesperidin also reversed the activity of H2O2 on inhibiting the Col2a1, aggrecan, and SOX9 gene expression and increasing the gene expression of caspase 3, IL-1beta, TNFalpha, iNOS, and MMP13.	Hesperidin	0-10	caspase 3	Rattus norvegicus	145-154	
25217884-8	2014	Individually, curcumin was more effective than hesperidin in reducing the levels of oxidized lipids, proteins, cleaved caspase-3 expression and mitochondrial enzymes.	Hesperidin	47-57	caspase 3	Rattus norvegicus	119-128	
25559243-7	2015	Not only yuzu but also hesperidin inhibited caspase-3 activity, myeloperoxidase expression, alpha-smooth muscle actin expression, and matrix metalloproteinase-2 activity in a permanent LAD occlusion rat model.	Hesperidin	23-33	caspase 3	Rattus norvegicus	44-53	
23353054-8	2013	Hesperidin treatment significantly attenuated the cisplatin-induced oxidative stress/lipid peroxidation, inflammation (infiltration of leukocytes and pro-inflammatory cytokine), apoptosis/necrosis (caspase-3 activity with DNA damage) as well as increased expression of nitric oxide in the kidney and improved renal function.	Hesperidin	0-10	caspase 3	Rattus norvegicus	198-207	
23475456-7	2013	Furthermore, hesperidin inhibited mitochondria-dependent downstream caspase-mediated apoptotic pathway, such as that involving caspase-9 and caspase-3.	Hesperidin	13-23	caspase 3	Rattus norvegicus	141-150